Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jan Stetka"'
Autor:
Damien Luque Paz, Michael S. Bader, Ronny Nienhold, Shivam Rai, Tiago Almeida Fonseca, Jan Stetka, Hui Hao-Shen, Gabriele Mild-Schneider, Jakob R. Passweg, Radek C. Skoda
Publikováno v:
HemaSphere, Vol 7, Iss 5, p e885 (2023)
Myeloproliferative neoplasms (MPNs) are caused by a somatic gain-of-function mutation in 1 of the 3 disease driver genes JAK2, MPL, or CALR. About half of the MPNs patients also carry additional somatic mutations that modify the clinical course. The
Externí odkaz:
https://doaj.org/article/81859577bfc14bcca1747a3f6ad405a3
Autor:
Jan Stetka, Radek C. Skoda
Publikováno v:
Biomedical Papers, Vol 165, Iss 1, Pp 26-33 (2021)
Myeloproliferative neoplasms (MPN), are clonal hematopoietic stem cell (HSC) disorders driven by gain-of-function mutations in JAK2 (JAK2-V617F), CALR or MPL genes. MPN treatment options currently mainly consist of cytoreductive therapy with hydroxyu
Externí odkaz:
https://doaj.org/article/6a1ab541fe914f408c83d3bee9d907b1
Autor:
Jan Stetka, Marc Usart, Lucia Kubovcakova, Shivam Rai, Tata Nageswara Rao, Joshua Sutter, Hui Hao-Shen, Stefan Dirnhofer, Florian Geier, Michael Stephan Bader, Jakob R Passweg, Vania Manolova, Franz Dürrenberger, Nouraiz Ahmed, Timm Schroeder, Tomas Ganz, Elizabeta Nemeth, Laura Silvestri, Antonella Nai, Clara Camaschella, Radek C. Skoda
Publikováno v:
Blood.
JAK2-V617F mutation causes myeloproliferative neoplasms (MPN) that can manifest as polycythemia vera (PV), essential thrombocythemia (ET) or primary myelofibrosis (PMF). PV patients at diagnosis already exhibited iron deficiency, whereas ET patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7a6188549c5643bf771ebb159434692
https://doi.org/10.1182/blood.2022017976
https://doi.org/10.1182/blood.2022017976
Autor:
Melissa Lock, Damien Luque Paz, Nils Hansen, Tiago Almeida Fonseca, MARC Usart, Shivam Rai, Hui Hao-Shen, Gabriele Mild, Stephan Dirnhofer, Radek C. Skoda, Jan Stetka
Publikováno v:
Blood. 140:3876-3877
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::639d69471d1918b6fabf2ff3b6ddb3fc
https://doi.org/10.1182/blood-2022-167002
https://doi.org/10.1182/blood-2022-167002
Autor:
Shivam Rai, Jan Stetka, MARC Usart, Hui Hao-Shen, Young Park, Remie Houston, Anthony R. Martinez Benitez, Matthew Wereski, Emily Guzzardi, Sonali Persaud, Hailey Ramzan, Alan Futran, Charley Xu, Jeremy Greenwood, Sayan Mondal, Craig Masse, Ross L. Levine, Radek C. Skoda, Andrew Dunbar
Publikováno v:
Blood. 140:6722-6723
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9b9924b5bf6ec7aa42489c053bb6ff9
https://doi.org/10.1182/blood-2022-162621
https://doi.org/10.1182/blood-2022-162621
Autor:
Sona Hubackova, Patrik Flodr, Jiri Bartek, Vladimir Divoky, Jan Gursky, Pavla Koralkova, Zdenek Hodny, Pavla Vyhlidalova, Jan Stetka, A Hlusi, Lucie Lanikova
Publikováno v:
Oncogene
Inflammatory and oncogenic signaling converge in disease evolution of BCR–ABL-negative myeloproliferative neoplasms, clonal hematopoietic stem cell disorders characterized by gain-of-function mutation in JAK2 kinase (JAK2V617F), with highest preval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f039a09c241387420425425f244a8e86
https://doi.org/10.1038/s41388-019-0813-7
https://doi.org/10.1038/s41388-019-0813-7
Autor:
Jan Stetka, Nouraiz Ahmed, Christian Beisel, Damien Luque Paz, Nils Hansen, Julian Hilfiker, Dominik Wolf, Steffen Koschmieder, Florian Geier, Hui Hao-Shen, Milena Kalmer, Stefan Dirnhofer, Tim H. Brümmendorf, Tata Nageswara Rao, Lucia Kubovcakova, Timm Schroeder, Max Endele, Margareta Rybarikova, Radek C. Skoda
Publikováno v:
Blood
Blood, 137 (16)
Blood, 137 (16)
We studied a subset of hematopoietic stem cells (HSCs) that are defined by elevated expression of CD41 (CD41hi) and showed bias for differentiation toward megakaryocytes (Mks). Mouse models of myeloproliferative neoplasms (MPNs) expressing JAK2-V617F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622010d9de59c7bbdfe5a74c85004689
https://europepmc.org/articles/PMC8103999/
https://europepmc.org/articles/PMC8103999/
Autor:
Vladimir Divoky, Monika Belickova, Pavla Vyhlidalova, Jitka Vesela, Alzbeta Hlavackova, Jiri Suttnar, Monika Kaisrlikova, Katarina Szikszai, Anna Jonasova, Patrik Flodr, Zdenek Krejcik, Jan Stetka, Pavla Koralkova, David Kundrat, Jan Stritesky, Michaela Dostalova Merkerova, Jaroslav Cermak
Publikováno v:
Cancers
Cancers, Vol 13, Iss 2161, p 2161 (2021)
Volume 13
Issue 9
Cancers, Vol 13, Iss 2161, p 2161 (2021)
Volume 13
Issue 9
Simple Summary Epigenetic drugs, such as azacitidine (AZA), hold promise in the treatment of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), however, the mechanisms predicting the patients’ response to AZA is not completely unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c2c750a01f8fbd3b1728307c2641fd
http://europepmc.org/articles/PMC8125503
http://europepmc.org/articles/PMC8125503
Autor:
Jan Stetka, Radek C. Skoda
Publikováno v:
Biomedical Papers, Vol 165, Iss 1, Pp 26-33 (2021)
Myeloproliferative neoplasms (MPN), are clonal hematopoietic stem cell (HSC) disorders driven by gain-of-function mutations in JAK2 (JAK2-V617F), CALR or MPL genes. MPN treatment options currently mainly consist of cytoreductive therapy with hydroxyu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33adf5d369fea3e0c835015045b82d9
https://pubmed.ncbi.nlm.nih.gov/33542546
https://pubmed.ncbi.nlm.nih.gov/33542546
Autor:
Julie Liñan Velasquez, Pavla Vyhlidalova, Jiri Bartek, Jan Gursky, Renata Mojzikova, Jan Stetka, Vladimir Divoky, Lucia Vráblová
Publikováno v:
Cancers, Vol 12, Iss 903, p 903 (2020)
Cancers
Cancers
Inflammatory and oncogenic signaling, both known to challenge genome stability, are key drivers of BCR-ABL-positive chronic myeloid leukemia (CML) and JAK2 V617F-positive chronic myeloproliferative neoplasms (MPNs). Despite similarities in chronic in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1329ef56e757410de4150e311a8bb00
https://www.mdpi.com/2072-6694/12/4/903
https://www.mdpi.com/2072-6694/12/4/903