Zobrazeno 1 - 10
of 897
pro vyhledávání: '"Jan Stephan"'
Autor:
Silke E. de Boer, Tim. J. Knobbe, Daan Kremer, Barbara C. van Munster, Gertrude J. Nieuwenhuijs-Moeke, Robert A. Pol, Stephan J. L. Bakker, Stefan P. Berger, Jan Stephan F. Sanders
Publikováno v:
Transplant International, Vol 37 (2024)
Kidney transplantation is the best treatment for kidney failure in older patients. However, little is known regarding changes in health-related quality of life (HRQoL) from before to after transplantation and determinants of HRQoL in older kidney tra
Externí odkaz:
https://doaj.org/article/fa783830be714c2a943f62e7e6eabcef
Autor:
Clare Andradi-Brown, Jan Stephan Wichers-Misterek, Heidrun von Thien, Yannick D Höppner, Judith AM Scholz, Helle Hansson, Emma Filtenborg Hocke, Tim Wolf Gilberger, Michael F Duffy, Thomas Lavstsen, Jake Baum, Thomas D Otto, Aubrey J Cunnington, Anna Bachmann
Publikováno v:
eLife, Vol 12 (2024)
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the highly polymorp
Externí odkaz:
https://doaj.org/article/ee63f3338efa4b578bd3c5c0608fd5e0
The Kelch13 compartment contains highly divergent vesicle trafficking proteins in malaria parasites.
Autor:
Sabine Schmidt, Jan Stephan Wichers-Misterek, Hannah Michaela Behrens, Jakob Birnbaum, Isabelle G Henshall, Jana Dröge, Ernst Jonscher, Sven Flemming, Carolina Castro-Peña, Paolo Mesén-Ramírez, Tobias Spielmann
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011814 (2023)
Single amino acid changes in the parasite protein Kelch13 (K13) result in reduced susceptibility of P. falciparum parasites to artemisinin and its derivatives (ART). Recent work indicated that K13 and other proteins co-localising with K13 (K13 compar
Externí odkaz:
https://doaj.org/article/44e7f5ab55c5407f99bc15ea3c9f69d5
Autor:
Jan Stephan Wichers-Misterek, Annika M. Binder, Paolo Mesén-Ramírez, Lilian Patrick Dorner, Soraya Safavi, Gwendolin Fuchs, Tobias L. Lenz, Anna Bachmann, Danny Wilson, Friedrich Frischknecht, Tim-Wolf Gilberger
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/2003f8bc3d7e413786beb48d0a785701
Autor:
Caecilia S. E. Doorenbos, Jip Jonker, Jiasi Hao, Edmund J. Gore, Daan Kremer, Tim J. Knobbe, Anoek A. E. de Joode, Jan Stephan F. Sanders, Olivier Thaunat, Hubert G. M. Niesters, Coretta C. Van Leer-Buter, Stephan J. L. Bakker
Publikováno v:
Viruses, Vol 15, Iss 12, p 2387 (2023)
Torque Teno Virus (TTV) is a non-pathogenic virus that is highly prevalent among kidney transplant recipients (KTRs). Its circulating load is associated with an immunological status in KTR and is considered a promising tool for guiding immunosuppress
Externí odkaz:
https://doaj.org/article/2031dcdf28054e97bc39d0f813c3ea35
Autor:
Benjamin Liffner, Juan Miguel Balbin, Gerald J. Shami, Ghizal Siddiqui, Jan Strauss, Sonja Frölich, Gary K. Heinemann, Ella May Edwards, Arne Alder, Jan Stephan Wichers, Darren J. Creek, Leann Tilley, Matthew W. A. Dixon, Tim-Wolf Gilberger, Danny W. Wilson
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Benjamin Liffner and Miguel Balbin et al. report that the Plasmodium falciparum protein, PfCERLI2, localises to the cytosolic face of the parasite’s rhoptry bulb and is essential for invasion and growth within human red blood cells.
Externí odkaz:
https://doaj.org/article/70f7a6eab0ab4db184482b483285f76e
Autor:
Jan Stephan Wichers-Misterek, Annika M. Binder, Paolo Mesén-Ramírez, Lilian Patrick Dorner, Soraya Safavi, Gwendolin Fuchs, Tobias L. Lenz, Anna Bachmann, Danny Wilson, Friedrich Frischknecht, Tim-Wolf Gilberger
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Mature gametocytes of Plasmodium falciparum display a banana (falciform) shape conferred by a complex array of subpellicular microtubules (SPMT) associated with the inner membrane complex (IMC). Microtubule-associated proteins (MAPs) define
Externí odkaz:
https://doaj.org/article/710728579d33454a8219a2cfe937fc9a
Autor:
Jan Stephan Bolten, Christine Tanner, Griffin Rodgers, Georg Schulz, Soledad Levano, Timm Weitkamp, Samuel Waldner, Ramya Deepthi Puligilla, Daniel Bodmer, Bert Müller, Jörg Huwyler
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284562 (2023)
Nephrotoxicity is an important drug safety aspect to be assessed during drug discovery and development. To study renal toxicity, in vitro cell-based assays are often used. Unfortunately, translating the results of such cell assays to vertebrates incl
Externí odkaz:
https://doaj.org/article/704316967a424cb0acc9a205ec2a8f5e
Autor:
Jan Stephan Wichers, Paolo Mesén-Ramírez, Gwendolin Fuchs, Jing Yu-Strzelczyk, Jan Stäcker, Heidrun von Thien, Arne Alder, Isabelle Henshall, Benjamin Liffner, Georg Nagel, Christian Löw, Danny Wilson, Tobias Spielmann, Shiqiang Gao, Tim-Wolf Gilberger, Anna Bachmann, Jan Strauss
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Membrane transport proteins perform crucial roles in cell physiology. The obligate intracellular parasite Plasmodium falciparum, an agent of human malaria, relies on membrane transport proteins for the uptake of nutrients from the host, disp
Externí odkaz:
https://doaj.org/article/a379ad10a39b42889f322ee25fa90b4b
Autor:
Jan Stephan Wichers, Carolina van Gelder, Gwendolin Fuchs, Julia Mareike Ruge, Emma Pietsch, Josie L. Ferreira, Soraya Safavi, Heidrun von Thien, Paul-Christian Burda, Paolo Mesén-Ramirez, Tobias Spielmann, Jan Strauss, Tim-Wolf Gilberger, Anna Bachmann
Publikováno v:
mSphere, Vol 6, Iss 6 (2021)
ABSTRACT During the symptomatic human blood phase, malaria parasites replicate within red blood cells. Parasite proliferation relies on the uptake of nutrients, such as amino acids, from the host cell and blood plasma, requiring transport across mult
Externí odkaz:
https://doaj.org/article/38d7b0fafe1747a6b6d5b773d740b4e0