Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jan Stenvang Jepsen"'
Autor:
Jesper Wengel, Flemming Gundorph Hansen, Jan Stenvang Jepsen, Claus J. Nielsen, Nicolai K. Andersen, Patrick J. Hrdlicka, Kim F. Haselmann
Publikováno v:
Hrdlicka, P J, Andersen, N K, Jepsen, J S, Hansen, F G, Haselmann, K, Nielsen, C & Wengel, J 2005, ' Synthesis and biological evaluation of branched and conformationally restricted analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd) ', Bioorganic & Medicinal Chemistry, vol. 13, no. 7, pp. 2597-2621 . https://doi.org/10.1016/j.bmc.2005.01.029
The synthesis of branched and conformationally restricted analogs of the anticancer nucleosides 3′-C-ethynyluridine (EUrd) and 3′-C-ethynylcytidine (ECyd) is presented. Molecular modeling and 1H NMR coupling constant analysis revealed that the fu
Publikováno v:
Hrdlicka, P J, Jepsen, J S & Wengel, J 2005, ' Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECYD) ', Nucleosides, Nucleotides and Nucleic Acids, vol. 24, no. 5-7, pp. 397-400 . https://doi.org/10.1081/NCN-200059821
A series of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3′-C-ethynylcytidine (ECyd) and its uracil analog (EUrd) have been synthesized. While none of, the conformationally restricted analogs displayed anti
Autor:
Christian Schetter, Tanja Wader, Arthur M. Krieg, Jörg Vollmer, Meike Wüllner, Jan Stenvang Jepsen, Eugen Uhlmann, Marion Jurk
Publikováno v:
Oligonucleotides. 14:23-31
Locked nucleic acid (LNA) is an RNA derivative that when introduced into oligodeoxynucleotides (ODN), mediates high efficacy and stability. CpG ODNs are potent immune stimulators and are recognized by toll-like receptor-9 (TLR9). Some phosphorothioat
Autor:
Jan Stenvang, Jepsen, Jesper, Wengel
Publikováno v:
Current opinion in drug discoverydevelopment. 7(2)
Locked nucleic acid (LNA) is a class of nucleic acid analogs possessing unprecedented binding affinity toward complementary DNA and RNA while obeying the Watson-Crick base-pairing rules. For efficient gene silencing in vitro and in vivo, fully modifi
Publikováno v:
Oligonucleotides. 14(2)
Locked nucleic acid (LNA) is a nucleic acid analog with very high affinity to complementary RNA and a promising compound in the field of antisense research. The intracellular localization and quantitative uptake of oligonucleotides containing LNA wer
Publikováno v:
Oligonucleotides; Summer2004, Vol. 14 Issue 2, p130-146, 17p
Publikováno v:
Oligonucleotides; Summer2004, Vol. 14 Issue 2, p147-156, 10p
Autor:
Jörg Vollmer, Jan Stenvang Jepsen, Eugen Uhlmann, Christian Schetter, Marion Jurk, Tanja Wader, Meike Wüllner, Arthur M. Krieg
Publikováno v:
Oligonucleotides; Spring2004, Vol. 14 Issue 1, p23-31, 9p
Autor:
Høyer-Hansen, M.1, Bastholm, L.2, Mathiasen, I. S.1,3, Elling, F.2, Jäättelä, M.1 mj@cancer.dk
Publikováno v:
Cell Death & Differentiation. Oct2005, Vol. 12 Issue 10, p1297-1309. 13p.
Publikováno v:
Biotech Week; 8/11/2004, p378-378, 1p