Associations between markers of inflammation and altered pain perception mechanisms in people with knee osteoarthritis: a systematic review

Autor: Ruth Wittoek, Patrick Calders, Sophie De Mits, Paolo Dainese, Hanne Mahieu, Jan Stautemas

Publikováno v: RMD Open, Vol 9, Iss 2 (2023)

To provide an extensive review on the associations between knee inflammation and altered pain perception mechanisms in people with knee osteoarthritis (OA). MEDLINE, Web of Science, EMBASE and Scopus were searched up to 13 December 2022. We included

Externí odkaz: https://doaj.org/article/db56b47e2d164a619071bbe7d6a96336

Pharmacokinetics of β-Alanine Using Different Dosing Strategies

Autor: Jan Stautemas, Inge Everaert, Filip B. D. Lefevere, Wim Derave

Publikováno v: Frontiers in Nutrition, Vol 5 (2018)

Introduction: The ergogenic response following long-term ingestion of β-alanine shows a high inter-individual variation. It is hypothesized that this variation is partially caused by a variable pharmacokinetic response induced by inferior dosing str

Externí odkaz: https://doaj.org/article/8d82ef31bdf141e099036e3883a536c9

Extensive profiling of histidine-containing dipeptides reveals species- and tissue-specific distribution and metabolism in mice, rats and humans

Autor: Thibaux Van der Stede, Jan Spaas, Sarah de Jager, Jana De Brandt, Camilla Hansen, Jan Stautemas, Bjarne Vercammen, Siegrid De Baere, Siska Croubels, Charles-Henri Van Assche, Berta Cillero Pastor, Michiel Vandenbosch, Ruud Van Thienen, Kenneth Verboven, Dominique Hansen, Thierry Bové, Bruno Lapauw, Charles Van Praet, Karel Decaestecker, Bart Vanaudenaerde, Bert O Eijnde, Lasse Gliemann, Ylva Hellsten, Wim Derave

Histidine-containing dipeptides (HCDs) are pleiotropic homeostatic molecules linked to inflammatory, metabolic and neurological diseases, as well as exercise performance. Using a sensitive UHPLC-MS/MS approach and an optimized quantification method,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4966c96461479082f08a7b01df1d0579
https://doi.org/10.1101/2023.02.16.528841

Acute Effects of Cocoa Flavanols on Blood Pressure and Peripheral Vascular Reactivity in Type 2 Diabetes Mellitus and Essential Hypertension

Autor: Anouk Tanghe, Elsa Heyman, Elodie Lespagnol, Jan Stautemas, Bert Celie, Jos Op ‘t Roodt, Ernst Rietzschel, Danusa Dias Soares, Nina Hermans, Emmy Tuenter, Samyah Shadid, Patrick Calders

Publikováno v: Nutrients
Nutrients, 2022, 14 (13), pp.2692. ⟨10.3390/nu14132692⟩
Nutrients; Volume 14; Issue 13; Pages: 2692
Nutrients, 14(13):2692. Multidisciplinary Digital Publishing Institute (MDPI)
NUTRIENTS

International audience; Background: Type 2 diabetes mellitus (T2DM) is associated with a high risk of vascular complications. Interestingly, cocoa flavanols (CF) can exert beneficial vascular effects in non-diabetic subjects. However, these effects h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658dbf10f4816358a01c6b4b5631e2d3
https://doi.org/10.3390/nu14132692

The role of alanine glyoxylate transaminase-2 (agxt2) in β-alanine and carnosine metabolism of healthy mice and humans

Autor: Natalia Jarzebska, Wim Derave, Anneke Volkaert, Chang Keun Kim, Jens Martens-Lobenhoffer, Roman N. Rodionov, Arne Hautekiet, Sarah de Jager, Stefanie M. Bode-Böger, Zhou Xiang Shan, Jan Stautemas, Inge Everaert, James Leiper, Siegrid De Baere, Filip Lefevere, Siska Croubels, Laura Blancquaert, Norbert Weiss

Publikováno v: European Journal of Applied Physiology. 120:2749-2759

Chronic β-alanine supplementation leads to increased levels of muscle histidine-containing dipeptides. However, the majority of ingested β-alanine is, most likely, degraded by two transaminases: GABA-T and AGXT2. In contrast to GABA-T, the in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a81fb4a217f4f447d2e5a66ae5812c2
https://doi.org/10.1007/s00421-020-04501-7