Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jan Stöhr"'
Autor:
Tariq Afroz, Elodie Chevalier, Mickael Audrain, Christopher Dumayne, Tamar Ziehm, Roger Moser, Anne-Laure Egesipe, Lorène Mottier, Monisha Ratnam, Manuela Neumann, Daniel Havas, Romain Ollier, Kasia Piorkowska, Mayank Chauhan, Alberto B. Silva, Samjhana Thapa, Jan Stöhr, Andrej Bavdek, Valerie Eligert, Oskar Adolfsson, Peter T. Nelson, Sílvia Porta, Virginia M.-Y. Lee, Andrea Pfeifer, Marie Kosco-Vilbois, Tamara Seredenina
Publikováno v:
Neurobiology of Disease, Vol 179, Iss , Pp 106050- (2023)
Effective therapies are urgently needed to safely target TDP-43 pathology as it is closely associated with the onset and development of devastating diseases such as frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) and amyotrophic la
Externí odkaz:
https://doaj.org/article/0ae8a176004d45538a54e3b880d79375
Autor:
Lars Luers, Oliver Bannach, Jan Stöhr, Michael Marius Wördehoff, Martin Wolff, Luitgard Nagel-Steger, Detlev Riesner, Dieter Willbold, Eva Birkmann
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72623 (2013)
Prion diseases are transmissible spongiform encephalopathies in humans and animals, including scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease (CWD) in deer, and Creutzfeldt-Jakob disease (CJD) in humans. Th
Externí odkaz:
https://doaj.org/article/90264ae12c074bb1b9292aa470c403e4
Autor:
Joel C Watts, Jan Stöhr, Sumita Bhardwaj, Holger Wille, Abby Oehler, Stephen J Dearmond, Kurt Giles, Stanley B Prusiner
Publikováno v:
PLoS Pathogens, Vol 7, Iss 11, p e1002382 (2011)
The central event in prion diseases is the conformational conversion of the cellular prion protein (PrP(C)) into PrP(Sc), a partially protease-resistant and infectious conformer. However, the mechanism by which PrP(Sc) causes neuronal dysfunction rem
Externí odkaz:
https://doaj.org/article/231bd22d391c4443a3bd25e5e8b0c570
Autor:
Giannantonio Panza, Lars Luers, Jan Stöhr, Luitgard Nagel-Steger, Jürgen Weiss, Detlev Riesner, Dieter Willbold, Eva Birkmann
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14283 (2010)
Prion diseases like Creutzfeldt-Jakob disease in humans, Scrapie in sheep or bovine spongiform encephalopathy are fatal neurodegenerative diseases, which can be of sporadic, genetic, or infectious origin. Prion diseases are transmissible between diff
Externí odkaz:
https://doaj.org/article/b2431ef0d6374eac9693093cffcd8333
Autor:
Randall M. Chin, Rishi Rakhit, Dara Ditsworth, Chengzhong Wang, Johan Bartholomeus, Song Liu, Akash Mody, Alex Laishu, Andrea Eastes, Chao Tai, Roy Y. Kim, Jessica Li, Steven Hansberry, Saurabh Khasnavis, Victoria Rafalski, Donald Herendeen, Virginia Garda, Jennie Phung, Daniel de Roulet, Alban Ordureau, J. Wade Harper, Shawn Johnstone, Jan Stöhr, Nicholas T. Hertz
Publikováno v:
bioRxiv
SummaryPINK1 loss-of-function mutations and exposure to mitochondrial toxins are causative for Parkinson’s disease (PD) and Parkinsonism, respectively. We demonstrate that pathological α-synuclein deposition, the hallmark pathology of idiopathic P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3fad76b3d26d9c2bf871d99febd863
https://doi.org/10.1101/2023.02.14.528378
https://doi.org/10.1101/2023.02.14.528378
Autor:
Jan Stöhr
Publikováno v:
Kohärente Entwicklungszusammenarbeit durch Recht ISBN: 9783428586806
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce3348e2e5bd3425f79b566673776402
https://doi.org/10.3790/978-3-428-58680-6
https://doi.org/10.3790/978-3-428-58680-6
Autor:
William F. DeGrado, Stanley B. Prusiner, Julia Becker, Mark J. S. Kelly, Manasi P. Bhate, Srabasti Acharya, Mimi Nick, Gerald Stubbs, Kathleen Robinson, Haifan Wu, Carlo Condello, Feng Gai, Jan Stöhr, Jeffrey M. Rodgers, Yibing Wu, Thomas Lemmin, Noah R. Johnson
Publikováno v:
Nature Chemistry. 9:874-881
The self-propagation of misfolded conformations of tau underlies neurodegenerative diseases, including Alzheimer’s disease. There is considerable interest in discovering the minimal sequence and active conformational nucleus that defines this self-
Autor:
Glenda M. Halliday, Carlo Condello, Sjoerd G. van Duinen, Lars Lannfelt, Stanley B. Prusiner, Joanne C. Lee, Weizhou Yue, C. Dirk Keene, Amanda L. Woerman, Brianna M. Rivera, Martin Ingelsson, William F. DeGrado, Atsushi Aoyagi, Jan Stöhr, Caroline Graff, Thomas D. Bird, William W. Seeley
Publikováno v:
Sci Transl Med
Science Translational Medicine, 11(490). AMER ASSOC ADVANCEMENT SCIENCE
Science Translational Medicine, 11(490). AMER ASSOC ADVANCEMENT SCIENCE
The hallmarks of Alzheimer's disease (AD) are the accumulation of A beta plaques and neurofibrillary tangles composed of hyperphosphorylated tau. We developed sensitive cellular assays using human embryonic kidney-293T cells to quantify intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525e4ae40e33592fd831ddb18fadabae
https://hdl.handle.net/1887/121879
https://hdl.handle.net/1887/121879
Publikováno v:
Biopolymers, vol 109, iss 8
The hydrophobic Aβ peptide is highly aggregation prone; it first forms soluble oligomers, which then convert into the amyloid fibrils found in the cerebral plaques of Alzheimer’s disease. It is generally understood that as the peptide concentratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a5825f6a02df638d68865705952c2b
https://escholarship.org/uc/item/9ct1f42h
https://escholarship.org/uc/item/9ct1f42h
Autor:
William F. DeGrado, Glenda M. Halliday, Stanley B. Prusiner, Sjoerd G. van Duinen, Amanda L. Woerman, Carlo Condello, Lars Lannfelt, Thomas D. Bird, Joanne C. Lee, Jan Stöhr, Atsushi Aoyagi, William W. Seeley, Caroline Graff, C. Dirk Keene, Brianna M. Rivera, Martin Ingelsson
Publikováno v:
Alzheimer's & Dementia. 14