Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Jan Sperl"'
Publikováno v:
Life, Vol 13, Iss 4, p 932 (2023)
Background and objectives: HCV infection often remains untreated in people who inject drugs (PWID), albeit they may present with advanced liver fibrosis at a young age. We aimed to assess the rate of patients with significant fibrosis in PWID startin
Externí odkaz:
https://doaj.org/article/09030904c3aa4ad69be3c5328b700d61
Publikováno v:
Harm Reduction Journal, Vol 18, Iss 1, Pp 1-9 (2021)
Abstract Background Intravenous drug use (IVDU) represents the major factor of HCV transmission, but the treatment uptake among people who inject drugs (PWID) remains low owing to a false presumption of low efficacy. The aim of our study was to asses
Externí odkaz:
https://doaj.org/article/39244e93a5f04f92a1ddd9df35d42d17
Autor:
Klara Horackova, Sona Frankova, Petra Zemankova, Petr Nehasil, Marta Cerna, Magdalena Neroldova, Barbora Otahalova, Jan Kral, Milena Hovhannisyan, Viktor Stranecky, Tomas Zima, Marketa Safarikova, Marta Kalousova, CZECANCA Consortium, Jan Novotny, Jan Sperl, Marianna Borecka, Sandra Jelinkova, Michal Vocka, Marketa Janatova, Petra Kleiblova, Zdenek Kleibl, Milan Jirsa, Jana Soukupova
Publikováno v:
Cancers, Vol 15, Iss 1, p 201 (2022)
Hepatocellular carcinoma (HCC) mainly stems from liver cirrhosis and its genetic predisposition is believed to be rare. However, two recent studies describe pathogenic/likely pathogenic germline variants (PV) in cancer-predisposition genes (CPG). As
Externí odkaz:
https://doaj.org/article/eff99fcdc2714e248af2543f3a58c41d
Autor:
Sona Frankova, Mariia Lunova, Halima Gottfriedova, Renata Senkerikova, Magdalena Neroldova, Jozef Kovac, Eva Kieslichova, Vera Lanska, Petr Urbanek, Julius Spicak, Milan Jirsa, Jan Sperl
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0244934 (2021)
Liver stiffness is a reliable non-invasive predictor of Hepatic Venous Pressure Gradient (HVPG) above 10 mm Hg. However, it failed to predict higher thresholds of HVPG. Our aim was to investigate whether liver stiffness and selected previously publis
Externí odkaz:
https://doaj.org/article/15693fbee5f54d4c829a6be9e98c6fb3
Autor:
Robert Flisiak, Dorota Zarębska-Michaluk, Egle Ciupkeviciene, Sylvia Drazilova, Sona Frankova, Ivica Grgurevic, Bela Hunyady, Peter Jarcuska, Limas Kupčinskas, Michael Makara, Gunita Saulite-Vanaga, Marieta Simonova, Jan Sperl, Ieva Tolmane, Adriana Vince
Publikováno v:
Viruses, Vol 14, Iss 3, p 482 (2022)
In 2016, the WHO announced a plan to eliminate viral hepatitis as a public health threat by 2030. In this narrative review, experts from Bulgaria, Croatia, the Czech Republic, Hungary, Latvia, Lithuania, Poland and Slovakia assessed the feasibility o
Externí odkaz:
https://doaj.org/article/73899e61351e4c9d9d7ca054a09abb60
Publikováno v:
Kidney & Blood Pressure Research, Vol 43, Iss 2, Pp 594-605 (2018)
Background/Aims: Chronic hepatitis C (HCV) virus infection reactivates under immunosuppressive drugs and therefore has a negative impact on long-term survival of kidney transplant recipients. Treatment-induced clearance of hepatitis C virus (HCV) in
Externí odkaz:
https://doaj.org/article/eb14cc8f477340b582de8283135f6fa9
Autor:
Zuzana Rabekova, Sona Frankova, Milan Jirsa, Magdalena Neroldova, Mariia Lunova, Ondrej Fabian, Martin Kveton, David Varys, Klara Chmelova, Vera Adamkova, Jaroslav A. Hubacek, Julius Spicak, Dusan Merta, Jan Sperl
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10560 (2021)
Heterozygotes for Z or S alleles of alpha-1-antrypsin (AAT) have low serum AAT levels. Our aim was to compare the risk of hepatocellular carcinoma (HCC) in patients with liver cirrhosis carrying the SERPINA1 MM, MZ and MS genotypes. The study groups
Externí odkaz:
https://doaj.org/article/49eab070c381406e9edb45a152ff0b01
Autor:
Renata Senkerikova, Sona Frankova, Milan Jirsa, Miluse Kreidlova, Dusan Merta, Magdalena Neroldova, Klara Chmelova, Julius Spicak, Jan Sperl
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222609 (2019)
BackgroundPNPLA3 rs738409 minor allele c.444G represents a risk factor for liver steatosis and fibrosis progression also in chronic hepatitis C (HCV). We investigated its impact on the timing of liver transplantation (LT) in patients with genotype 1b
Externí odkaz:
https://doaj.org/article/3b0996b9ca494923bf7c4a5439c5a4a7
Autor:
Halima Gottfriedová, Eva Kieslichova, Renata Senkerikova, Sona Frankova, Magdalena Neroldova, Jan Sperl, Julius Spicak, Mariia Lunova, Milan Jirsa, Jozef Kováč, Eva Sticova, Vera Lanska
Publikováno v:
Physiol Res
Liver stiffness (LS) is a novel non-invasive parameter widely used in clinical hepatology. LS correlates with liver fibrosis stage in non-cirrhotic patients. In cirrhotic patients it also shows good correlation with Hepatic Venous Pressure Gradient (
Autor:
Julius Spicak, Jan Sperl, Klara Chmelova, Jiří Fabián, Soňa Fraňková, David Varys, Veronika Pítová, Jiří Novotný, Janka Slatinská
Publikováno v:
Gastroenterologie a hepatologie. 75:304-310
Introduction: Cytomegalovirus disease affecting the gastrointestinal tract is a rare but severe disease presenting particularly in people under immunosuppression, solid organ transplant recipients and AIDS patients with CD4 count under 100/mm3. When