Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Jan Spengler"'
Publikováno v:
ARKIVOC, Vol 2005, Iss 6, Pp 191-199 (2005)
Externí odkaz:
https://doaj.org/article/92008e3d96ee43a6bea7a4ee112b8108
Autor:
Jan Spengler, Maria J. Macias, Fernando Albericio, Constanze Schelhorn, Michael Barker, Jesús García
Publikováno v:
Repositorio Universidad Regional Amazónica
Universidad Regional Amazónica
instacron:IKIAM
Universidad Regional Amazónica
instacron:IKIAM
A novo trifunctional EDTA-like peptidomimetic amino acid is described. This unique building block, which is prepared in a straightforward manner from commercialized starting materials, contains three moieties: a hexadentate chelating unit similar to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0352073c4604b15b6ec846ba12ee6bb0
https://doi.org/10.1039/c6cc10203d
https://doi.org/10.1039/c6cc10203d
Publikováno v:
Biopolymers. 104:435-452
Backbone N-substitution of peptides (N-Me and N-alkyl) has become of special interest as a chemical tool for peptide lead modification, either to improve biological activity or to optimize key pharmacokinetic characteristics. For the synthesis of bac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93b8cc2e356dcde7a1ede6c4619526a1
https://doi.org/10.1002/bip.22696
https://doi.org/10.1002/bip.22696
Adhesives with graded properties along the bondline are being developed to increase the strength of adhesively bonded joints. Efforts to do this in the past have resulted in mixed results. Two adhesive parameters need to be considered: the geometry o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7ca5b765d172d06fb882cbb972153e
https://publica.fraunhofer.de/handle/publica/251718
https://publica.fraunhofer.de/handle/publica/251718
Publikováno v:
Tetrahedron Letters. 55:184-188
In this study, the potential of N -alkoxymethyl groups as protectants for the peptide backbone has been investigated. These groups were found to be compatible with the standard conditions of Fmoc/ t Bu SPPS, and can be cleaved off from the peptide ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c0dfca0815182a7a4c22759ff441f17
https://doi.org/10.1016/j.tetlet.2013.10.149
https://doi.org/10.1016/j.tetlet.2013.10.149
Publikováno v:
Bioconjugate Chemistry. 25:11-17
Cilengitide is an RGD-peptide of sequence cyclo[RGDfNMeV] that was was developed as a highly active and selective ligand for the αvβ3 and αvβ5 integrin receptors. We describe the synthesis of three analogues of this peptide in which the N-Me grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f17496a6ac1ca63afd0ffc84000d2e8
https://doi.org/10.1021/bc4003844
https://doi.org/10.1021/bc4003844
Autor:
Jan Spengler, Fernando Albericio
Publikováno v:
European Journal of Organic Chemistry. 2014:44-47
Herein, we describe an efficient stereoselective synthesis of all the diastereomers of 2-amino-3-hydroxy-4,5-dimethylhexanoic acid. The γ-branched carbon skeleton was set up by reaction of Garner's aldehyde with 2-lithio-3-methyl-2-butene. Hydrogena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69d895fd8b981a79d4d71a3d594653b3
https://doi.org/10.1002/ejoc.201301257
https://doi.org/10.1002/ejoc.201301257
Autor:
Fernando Albericio, Gerardo A. Acosta, Yoav Luxembourg, Prabhakar Cherkupally, Hortensia Rodríguez, Lidia Nieto-Rodriguez, Jan Spengler, Rafel Prohens, Marina Shamis, Ramon Subiros-Funosas, Sherine N. Khattab, Ayman El-Faham
Publikováno v:
European Journal of Organic Chemistry. 2013:6372-6378
Here we present a new formulation of the recently introduced OxymaPure additive for peptide bond formation, in which the N-hydroxylamine group is replaced by a potassium salt. The complete suppression of its acidity converts KOxyma into the most suit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05c077f1fe39fb4e8cd8b6f9d01f83ba
https://doi.org/10.1002/ejoc.201300777
https://doi.org/10.1002/ejoc.201300777
Autor:
Jaume Adan, Ana I. Fernández-Llamazares, Francesc Mitjans, Jesús García, David Meunier, Fernando Albericio, Jan Spengler
Publikováno v:
Organic Letters. 15:4572-4575
A robust synthetic strategy for the introduction of the N-(4-azidobutyl) linker into peptides using standard SPPS techniques is described. Based on the example of Cilengitide it is shown that the N-(4-azidobutyl) group exerts similar conformational r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d07fff48838d130b15a5e5409c55c0
https://doi.org/10.1021/ol402150m
https://doi.org/10.1021/ol402150m
Autor:
Ana I. Fernández-Llamazares, Jan Spengler, Javier Ruiz-Rodríguez, Fernando Albericio, Klaus Burger
Publikováno v:
The Journal of Organic Chemistry. 75:5746-5749
An efficient strategy to synthesize tartaric acid building blocks for totally regioselective transformations or derivatizations was disclosed. Starting from l-tartaric acid or l-dimethyl tartrate, respectively, we obtained type I and II building bloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fe210fe93b8710af0455d91f31b813
https://doi.org/10.1021/jo101001s
https://doi.org/10.1021/jo101001s