Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jan Sodenkamp"'
Repeated clinical malaria episodes are associated with modification of the immune system in children
Autor:
Yaw Bediako, Rhys Adams, Adam J. Reid, John Joseph Valletta, Francis M. Ndungu, Jan Sodenkamp, Jedidah Mwacharo, Joyce Mwongeli Ngoi, Domtila Kimani, Oscar Kai, Juliana Wambua, George Nyangweso, Etienne P. de Villiers, Mandy Sanders, Magda Ewa Lotkowska, Jing-Wen Lin, Sarah Manni, John W. G. Addy, Mario Recker, Chris Newbold, Matthew Berriman, Philip Bejon, Kevin Marsh, Jean Langhorne
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-14 (2019)
Abstract Background There are over 200 million reported cases of malaria each year, and most children living in endemic areas will experience multiple episodes of clinical disease before puberty. We set out to understand how frequent clinical malaria
Externí odkaz:
https://doaj.org/article/bb064bb916684a2ca4a05449c002975e
Autor:
Katharina S. Schneider, Christina J. Groß, Roland F. Dreier, Benedikt S. Saller, Ritu Mishra, Oliver Gorka, Rosalie Heilig, Etienne Meunier, Mathias S. Dick, Tamara Ćiković, Jan Sodenkamp, Guillaume Médard, Ronald Naumann, Jürgen Ruland, Bernhard Kuster, Petr Broz, Olaf Groß
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3846-3859 (2017)
Inflammasomes activate the protease caspase-1, which cleaves interleukin-1β and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis. By generating mice expressing enzym
Externí odkaz:
https://doaj.org/article/caf0ef9e648d468094e235c5382d0983
Autor:
Damián Pérez-Mazliah, Dorothy Hui Lin Ng, Ana Paula Freitas do Rosário, Sarah McLaughlin, Béatris Mastelic-Gavillet, Jan Sodenkamp, Garikai Kushinga, Jean Langhorne
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004715 (2015)
Interleukin-21 signaling is important for germinal center B-cell responses, isotype switching and generation of memory B cells. However, a role for IL-21 in antibody-mediated protection against pathogens has not been demonstrated. Here we show that I
Externí odkaz:
https://doaj.org/article/cd124cd36cb24decaa5a49dfa6b3028b
Autor:
Roland F. Dreier, Ritu Mishra, Jürgen Ruland, Katharina S. Schneider, Tamara Cikovic, Jan Sodenkamp, Oliver Gorka, Ronald Naumann, Rosalie Heilig, Mathias S. Dick, Petr Broz, Etienne Meunier, Benedikt S. Saller, Christina J. Groß, Bernhard Kuster, Olaf Groß, Guillaume Médard
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3846-3859 (2017)
Cell Reports
Cell reports, vol. 21, no. 13, pp. 3846-3859
Cell Reports
Cell reports, vol. 21, no. 13, pp. 3846-3859
Summary Inflammasomes activate the protease caspase-1, which cleaves interleukin-1β and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis. By generating mice expressi
Autor:
Hagen Wende, Luke S. Cox, Caroline Hosking, Yashaswini Kannan, Anne O'Garra, Mark S. Wilson, James Briscoe, Damián Pérez-Mazliah, Xuemei Wu, Vicki Metzis, Jan Sodenkamp, Leona Gabryšová, Jean Langhorne, Michael H. Sieweke, Greg Elgar, Nicholas M. Luscombe, Raphaëlle Luisier, Marisol Alvarez-Martinez, Leena Bhaw, Krzysztof Potempa, Charlotte Whicher
Publikováno v:
Nature Immunology
Nature Immunology, Nature Publishing Group, 2018, 19 (5), pp.497-507
Nature Immunology, 2018, 19 (5), pp.497-507
Nature immunology
Nature Immunology, Nature Publishing Group, 2018, 19 (5), pp.497-507
Nature Immunology, 2018, 19 (5), pp.497-507
Nature immunology
The transcription factor c-Maf induces the anti-inflammatory cytokine IL-10 in CD4+ T cells in vitro. However, the global effects of c-Maf on diverse immune responses in vivo are unknown. Here we found that c-Maf regulated IL-10 production in CD4+ T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e39f0c4d8ee5af0454f0caca88fae6b
https://hal-amu.archives-ouvertes.fr/hal-02024582
https://hal-amu.archives-ouvertes.fr/hal-02024582
Autor:
Tshibuayi Christine Tshitenge, Deirdre Cunningham, Bradley Spencer-Dene, Jan Sodenkamp, Jing-wen Lin, Caroline Hosking, Anne O'Garra, Christine M. Graham, Katrien Deroost, Sarah McLaughlin, Jean Langhorne, Chris J. Janse, Tracey J. Lamb, Jai Ramesar
Publikováno v:
Scientific Reports
Scientific Reports, 7
Scientific Reports, 7
The influence of parasite genetic factors on immune responses and development of severe pathology of malaria is largely unknown. In this study, we performed genome-wide transcriptomic profiling of mouse whole blood during blood-stage infections of tw
Repeated clinical malaria episodes are associated with modification of the immune system in children
Autor:
Magda E. Lotkowska, S Manni, Adam J. Reid, Mandy Sanders, E. P. de Villiers, Juliana Wambua, Philip Bejon, Chris I. Newbold, George Nyangweso, Mario Recker, Rhys M. Adams, John Joseph Valletta, Domtila Kimani, Y Bediako, Francis M. Ndungu, Kevin Marsh, Lin J-W., Addy Jwg., Jan Sodenkamp, Jean Langhorne, Joyce M. Ngoi, Jedidah Mwacharo, Matthew Berriman, O Kai
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-14 (2019)
BMC Medicine
BMC Medicine
The study received funding from the UK Medical Research Council, (MRC Programme grant #: MR/M003906/1). MB and AR are supported by the Wellcome Trust (Grant #: WT 206194). Background There are over 200 million reported cases of malaria each year, and
Autor:
Raphaëlle Luisier, Leena Bhaw, Nicholas M. Luscombe, Xuemei Wu, Krzysztof Potempa, Leona Gabryšová, Jean Langhorne, Jan Sodenkamp, Greg Elgar, Marisol Alvarez-Martinez, Vicki Metzis, Luke S. Cox, Yashaswini Kannan, Damián Pérez-Mazliah, Michael H. Sieweke, Charlotte Whicher, Caroline Hosking, Anne O'Garra, James Briscoe, Mark S. Wilson, Hagen Wende
Publikováno v:
Nature Immunology. 20:374-374
In the version of this article initially published, the Supplementary Data file was an incorrect version. The correct version is now provided. The error has been corrected in the HTML and PDF version of the article.
Autor:
Philip J Spence, William Jarra, Jean Langhorne, Joanne Thompson, Deirdre Cunningham, Jan Sodenkamp, Thibaut Brugat, Mark S. Wilson, Stephanie M. Coomes, Cheryl L. Scudamore
Publikováno v:
Cellular Microbiology
Cellular Microbiology; Vol 16
Cellular Microbiology; Vol 16
Summary Infection with the malaria parasite, Plasmodium ,i s associated with a strong inflammatory response and parasite cytoadhesion (sequestration) in several organs. Here, we have carried out a sys- tematic study of sequestration and histopatholog
Autor:
Jean Langhorne, Barbara Capuccini, Roberta Spaccapelo, Shahid M. Khan, Jing-wen Lin, Carlos Talavera-López, Jan Sodenkamp
Publikováno v:
Scientific Reports, 6
Scientific Reports
Scientific Reports
Cerebral malaria is a pathology involving inflammation in the brain. There are many immune cell types activated during this process, but there is little information on the response of microglia, in this severe complication. We examined microglia by g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed5a2a5da617d3b0af4945ef45153ab
http://hdl.handle.net/11391/1397213
http://hdl.handle.net/11391/1397213