Výsledky vyhledávání - "Jan Simon Boerma"

Effect of Human Glutathione S-Transferases on Glutathione-Dependent Inactivation of Cytochrome P450-Dependent Reactive Intermediates of Diclofenac

Autor: Jan N. M. Commandeur, Jan Simon Boerma, Sanja Dragovic, Nico P. E. Vermeulen

Publikováno v: Chemical Research in Toxicology, 26(11), 1632-1641. American Chemical Society
Dragovic, S, Boerma, J S, Vermeulen, N P E & Commandeur, J N M 2013, ' Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac. ', Chemical Research in Toxicology, vol. 26, no. 11, pp. 1632-1641 . https://doi.org/10.1021/tx400204d

Idiosyncratic adverse drug reactions due to the anti-inflammatory drug diclofenac have been proposed to be caused by the generation of reactive acyl glucuronides and oxidative metabolites. For the oxidative metabolism of diclofenac by cytochromes P45

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86016043a4d37a22b90a23cc07cc00bd
https://doi.org/10.1021/tx400204d

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Mass Spectrometric Characterization of Protein Adducts of Multiple P450-Dependent Reactive Intermediates of Diclofenac to Human Glutathione-S-transferase P1-1

Autor: Jan Simon Boerma, Jan N. M. Commandeur, Sanja Dragovic, Nico P. E. Vermeulen

Publikováno v: Chemical Research in Toxicology, 25(11), 2532-2541. American Chemical Society
Boerma, J S, Dragovic, S, Vermeulen, N P E & Commandeur, J N M 2012, ' Mass Spectrometric Characterization of Protein Adducts of Multiple P450-Dependent Reactive Intermediates of Diclofenac to Human Glutathione-S-transferase P1-1 ', Chemical Research in Toxicology, vol. 25, no. 11, pp. 2532-2541 . https://doi.org/10.1021/tx300334w

Use of the nonsteroidal anti-inflammatory drug diclofenac (DF) is associated with serious idiosyncratic hepatotoxicity. Covalent binding of reactive intermediates of DF to proteins is considered to initiate the process leading to this severe side-eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1318b4d1720e63b9f28dc4d8410adbf
https://hdl.handle.net/1871/41751

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Role of Residue 87 in the Activity and Regioselectivity of Clozapine Metabolism by Drug-Metabolizing CYP102A1 M11H: Application for Structural Characterization of Clozapine GSH Conjugates

Autor: Jan Simon Boerma, Jan N. M. Commandeur, Vanina Rea, Sanja Dragovic, Nico P. E. Vermeulen, Frans J. J. de Kanter

Publikováno v: Drug Metabolism and Disposition. 39:2411-2420

In the present study, a site-saturation mutagenesis library of drug-metabolizing CYP102A1 M11H with all 20 amino acids at position 87 was applied as a biocatalyst for the production of stable and reactive metabolites of clozapine. Clozapine is an aty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bb0c0dabc5839ef4b8dc2ff9988cb7
https://doi.org/10.1124/dmd.111.041046

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Application of CYP102A1M11H as a Tool for the Generation of Protein Adducts of Reactive Drug Metabolites

Autor: Jan N. M. Commandeur, Jan Simon Boerma, Nico P. E. Vermeulen

Publikováno v: Boerma, J S, Vermeulen, N P E & Commandeur, J N M 2011, ' Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites ', Chemical Research in Toxicology, vol. 24, no. 8, pp. 1263-1274 . https://doi.org/10.1021/tx2001515
Chemical Research in Toxicology, 24(8), 1263-1274. American Chemical Society

Covalent binding of reactive metabolites (RMs) to proteins is considered to be one of the important mechanisms by which drugs can cause tissue damage. To facilitate the study of drug-protein adducts, we developed a potentially generic method for prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ca36b8d240922028325d287905788e
https://doi.org/10.1021/tx2001515

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Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine

Autor: Jan N. M. Commandeur, Sanja Dragovic, Nico P. E. Vermeulen, Laura A. H. van Bergen, Jan Simon Boerma

Publikováno v: Dragovic, S, Boerma, J S, van Bergen, L, Vermeulen, N P E & Commandeur, J N M 2010, ' Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine. ', Chemical Research in Toxicology, vol. 23, no. 9, pp. 1467-1476 . https://doi.org/10.1021/tx100131f
Chemical Research in Toxicology, 23(9), 1467-1476. American Chemical Society

The conjugation of reactive drug metabolites to GSH is considered an important detoxification mechanism that can be spontaneous and/or mediated by glutathione S-transferases (GSTs). In case GSTs play an important role in GSH conjugation, genetically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641e9d5ee05ed1f778452af4407d1f35
https://doi.org/10.1021/tx100131f

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Mini-dialysis tubes as tools to prepare drug-protein adducts of P450-dependent reactive drug metabolites

Autor: Naura S. Elias, Jan N. M. Commandeur, Nico P. E. Vermeulen, Jan Simon Boerma

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis, 103, 17-25. Elsevier
Boerma, J S, Elias, N S, Vermeulen, N P E & Commandeur, J N M 2015, ' Mini-dialysis tubes as tools to prepare drug-protein adducts of P450-dependent reactive drug metabolites ', Journal of Pharmaceutical and Biomedical Analysis, vol. 103, pp. 17-25 . https://doi.org/10.1016/j.jpba.2014.10.025

The modification of critical cellular proteins by reactive metabolites (RMs) resulting from P450-dependent drug bioactivation is considered essential to the onset of many idiosyncratic drug reactions. In this study, we report a novel method that can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24de0630ae79a371872daf51bc77811
https://research.vu.nl/en/publications/2f964866-280c-4b3e-8d2f-a11392e32da4

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One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac

Autor: Jan N. M. Commandeur, Jan Simon Boerma, Nico P. E. Vermeulen

Publikováno v: Boerma, J S, Vermeulen, N P E & Commandeur, J N M 2014, ' One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac. ', Chemico-Biological Interactions, vol. 207, pp. 32-40 . https://doi.org/10.1016/j.cbi.2013.11.001
Chemico-Biological Interactions, 207, 32-40. Elsevier Ireland Ltd

Reactive metabolites have been suggested to play a role in the idiosyncratic hepatotoxicity observed with diclofenac (DF). By structural identification of the GSH conjugates formed after P450-catalyzed bioactivation of DF, it was shown that three typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112968811acd83dffd975ebe843bdd90
https://hdl.handle.net/1871.1/1f895e44-f497-40f9-adba-0bd04e014deb

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Role of Human Glutathione S-Transferases on the Inactivation of Reactive Drug METABOLITES of Clozapine

Autor: Sanja Dragovic, Jan Simon Boerma, Laura van Bergen, Nico P.E. Vermeulen, Commandeur, Jan N. M.

Publikováno v: Dragovic, S, Boerma, J S, van Bergen, L, Vermeulen, N P E & Commandeur, J N M 2010, ' Role of Human Glutathione S-Transferases on the Inactivation of Reactive Drug METABOLITES of Clozapine ', Drug Metabolism Reviews, vol. 42, pp. 67-67 .
Vrije Universiteit Amsterdam
Drug Metabolism Reviews, 42, 67-67. Informa Healthcare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::adac47b0d629109b0245627769ac2b25
https://hdl.handle.net/1871.1/b4cbf540-a024-4036-a574-d8a1edc7ea00

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Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites

Autor: Catherine S. Lane, Christopher E. Goldring, Jan-Simon Boerma, Rosalind E. Jenkins, B. Kevin Park, Jane Hamlett, Neil R. Kitteringham, Nico P. E. Vermeulen, Samantha M.J. Dowdall

Publikováno v: Jenkins, R E, Kitteringham, N R, Goldring, C E P, Dowdall, S M J, Hamlett, J, Lane, C S, Boerma, J-S, Vermeulen, N P E & Park, B K 2008, ' Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites ', Proteomics, vol. 8, no. 2, pp. 301-15 . https://doi.org/10.1002/pmic.200700843
Proteomics, 8(2), 301-15. Wiley-VCH Verlag

Chemically reactive metabolites (CRMs) are thought to be responsible for a number of adverse drug reactions through modification of critical proteins. Methods that defined the chemistry of protein modification at an early stage would provide invaluab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a1ab6373f30d1cfcf6c55ccfc50c4b
https://pubmed.ncbi.nlm.nih.gov/18203258

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