Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Jan Schuemann"'
Autor:
Jeremy M. Quintana, Mikyung Kang, Huiyu Hu, Thomas S. C. Ng, Gregory R. Wojtkiewicz, Ella Scott, Sareh Parangi, Jan Schuemann, Ralph Weissleder, Miles A. Miller
Publikováno v:
ACS Central Science, Vol 10, Iss 7, Pp 1371-1382 (2024)
Externí odkaz:
https://doaj.org/article/c3f80e25bbe34e328ba277b41fad204a
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionDNA damage is the main predictor of response to radiation therapy for cancer. Its Q8 quantification and characterization are paramount for treatment optimization, particularly in advanced modalities such as proton and alpha-targeted thera
Externí odkaz:
https://doaj.org/article/b68acf50eb9545669c76ca443db38b7e
Autor:
Samuel P. Ingram, John-William Warmenhoven, Nicholas T. Henthorn, Amy L. Chadiwck, Elham E. Santina, Stephen J. McMahon, Jan Schuemann, Norman F. Kirkby, Ranald I. Mackay, Karen J. Kirkby, Michael J. Merchant
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
PyFoci is a tool that simulates distributions of fluorescently labeled DNA double-strand break marker protein foci and allows the estimation of miscounting under different radiation types, doses and microscopy settings.
Externí odkaz:
https://doaj.org/article/12f2d24396fc42b6b08bfd133060527c
Autor:
Alexander P. Klapproth, Jan Schuemann, Stefan Stangl, Tianwu Xie, Wei Bo Li, Gabriele Multhoff
Publikováno v:
Cancer Nanotechnology, Vol 12, Iss 1, Pp 1-18 (2021)
Abstract Background Gold nanoparticles (AuNPs) are considered as promising agents to increase the radiosensitivity of tumor cells. However, the biological mechanisms of radiation enhancement effects of AuNPs are still not well understood. We present
Externí odkaz:
https://doaj.org/article/40aacbeb33784511b4ec6f9d793fdf29
Autor:
Qixian Zhang, Leo E. Gerweck, Ethan Cascio, Liqun Gu, Qingyuan Yang, Xinyue Dong, Peigen Huang, Alejandro Bertolet, Konrad Pawel Nesteruk, Wonmo Sung, Aimee L. McNamara, Jan Schuemann
Publikováno v:
Cancers, Vol 15, Iss 8, p 2269 (2023)
Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional dose rate irradiation. This tissue sparing has been termed the FLASH effect. We investigated the FLASH effect of proton irradiation on the intestine a
Externí odkaz:
https://doaj.org/article/ac9c787ada3c42079872bf598e94893d
Autor:
Tara Al Zubaidi, O. H. Fiete Gehrisch, Marie-Michelle Genois, Qi Liu, Shan Lu, Jong Kung, Yunhe Xie, Jan Schuemann, Hsiao-Ming Lu, Aaron N. Hata, Lee Zou, Kerstin Borgmann, Henning Willers
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Mutant KRAS is a common tumor driver and frequently confers resistance to anti-cancer treatments such as radiation. DNA replication stress in these tumors may constitute a therapeutic liability but is poorly understood. Here, using single-mo
Externí odkaz:
https://doaj.org/article/c9f65698ab184d44a3f15db972aba8ea
Autor:
Kyle Bromma, Kristy Rieck, Jayesh Kulkarni, Connor O’Sullivan, Wonmo Sung, Pieter Cullis, Jan Schuemann, Devika B. Chithrani
Publikováno v:
Cancer Nanotechnology, Vol 10, Iss 1, Pp 1-17 (2019)
Abstract Background Radiotherapy is commonly used for treating cancer. Novel sensitizers, such as gold nanoparticles (GNPs), are being used to enhance the local radiation dose. It is not known how the uptake and radiation dose enhancement of GNPs var
Externí odkaz:
https://doaj.org/article/38df13f482774eaf907c54067bc376fe
Autor:
Wei Bo Li, Stefan Stangl, Alexander Klapproth, Maxim Shevtsov, Alicia Hernandez, Melanie A. Kimm, Jan Schuemann, Rui Qiu, Bernhard Michalke, Mario A. Bernal, Junli Li, Kerstin Hürkamp, Yibao Zhang, Gabriele Multhoff
Publikováno v:
Cancers, Vol 13, Iss 21, p 5370 (2021)
High-Z gold nanoparticles (AuNPs) conjugated to a targeting antibody can help to improve tumor control in radiotherapy while simultaneously minimizing radiotoxicity to adjacent healthy tissue. This paper summarizes the main findings of a joint resear
Externí odkaz:
https://doaj.org/article/873298103d0c414da86571d8be331310
Autor:
Chao Wu, Dan Nguyen, Yixun Xing, Ana Barragan Montero, Jan Schuemann, Haijiao Shang, Yuehu Pu, Steve Jiang
Publikováno v:
Machine Learning: Science and Technology, Vol 2, Iss 1, p 015017 (2021)
Pencil beam (PB) dose calculation is fast but inaccurate due to the approximations when dealing with inhomogeneities. Monte Carlo (MC) dose calculation is the most accurate method but it is time consuming. The aim of this study was to develop a deep
Externí odkaz:
https://doaj.org/article/de95c3e2e77440d5aed069f95717b84b
Publikováno v:
Cancers, Vol 10, Iss 5, p 150 (2018)
Combined use of chemotherapy and radiation therapy is commonly used in cancer treatment, but the toxic effects on normal tissue are a major limitation. This study assesses the potential to improve radiation therapy when combining gold nanoparticle (G
Externí odkaz:
https://doaj.org/article/dcc586fb02164c7da9b5297ee648df1d