Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Jan Schuemann"'
Autor:
Jeremy M. Quintana, Mikyung Kang, Huiyu Hu, Thomas S. C. Ng, Gregory R. Wojtkiewicz, Ella Scott, Sareh Parangi, Jan Schuemann, Ralph Weissleder, Miles A. Miller
Publikováno v:
ACS Central Science, Vol 10, Iss 7, Pp 1371-1382 (2024)
Externí odkaz:
https://doaj.org/article/c3f80e25bbe34e328ba277b41fad204a
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionDNA damage is the main predictor of response to radiation therapy for cancer. Its Q8 quantification and characterization are paramount for treatment optimization, particularly in advanced modalities such as proton and alpha-targeted thera
Externí odkaz:
https://doaj.org/article/b68acf50eb9545669c76ca443db38b7e
Autor:
Samuel P. Ingram, John-William Warmenhoven, Nicholas T. Henthorn, Amy L. Chadiwck, Elham E. Santina, Stephen J. McMahon, Jan Schuemann, Norman F. Kirkby, Ranald I. Mackay, Karen J. Kirkby, Michael J. Merchant
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
PyFoci is a tool that simulates distributions of fluorescently labeled DNA double-strand break marker protein foci and allows the estimation of miscounting under different radiation types, doses and microscopy settings.
Externí odkaz:
https://doaj.org/article/12f2d24396fc42b6b08bfd133060527c
Autor:
Alexander P. Klapproth, Jan Schuemann, Stefan Stangl, Tianwu Xie, Wei Bo Li, Gabriele Multhoff
Publikováno v:
Cancer Nanotechnology, Vol 12, Iss 1, Pp 1-18 (2021)
Abstract Background Gold nanoparticles (AuNPs) are considered as promising agents to increase the radiosensitivity of tumor cells. However, the biological mechanisms of radiation enhancement effects of AuNPs are still not well understood. We present
Externí odkaz:
https://doaj.org/article/40aacbeb33784511b4ec6f9d793fdf29
Autor:
Tara Al Zubaidi, O. H. Fiete Gehrisch, Marie-Michelle Genois, Qi Liu, Shan Lu, Jong Kung, Yunhe Xie, Jan Schuemann, Hsiao-Ming Lu, Aaron N. Hata, Lee Zou, Kerstin Borgmann, Henning Willers
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Mutant KRAS is a common tumor driver and frequently confers resistance to anti-cancer treatments such as radiation. DNA replication stress in these tumors may constitute a therapeutic liability but is poorly understood. Here, using single-mo
Externí odkaz:
https://doaj.org/article/c9f65698ab184d44a3f15db972aba8ea
Autor:
Kyle Bromma, Kristy Rieck, Jayesh Kulkarni, Connor O’Sullivan, Wonmo Sung, Pieter Cullis, Jan Schuemann, Devika B. Chithrani
Publikováno v:
Cancer Nanotechnology, Vol 10, Iss 1, Pp 1-17 (2019)
Abstract Background Radiotherapy is commonly used for treating cancer. Novel sensitizers, such as gold nanoparticles (GNPs), are being used to enhance the local radiation dose. It is not known how the uptake and radiation dose enhancement of GNPs var
Externí odkaz:
https://doaj.org/article/38df13f482774eaf907c54067bc376fe
Publikováno v:
IEEE Transactions on Radiation and Plasma Medical Sciences. 7:213-224
We are in a golden age of progress in artificial intelligence (AI). Radiotherapy, due to its technology-intensive nature as well as direct human-machine interactions, is perfectly suited for benefitting from AI to enhance accuracy and efficiency. Ove
Autor:
J Naoki D-Kondo, Omar Rodrigo Garcia Garcia, Jay A LaVerne, Bruce A Faddegon, Jan Schuemann, Wook-Geun Shin, Jose Ramos-Mendez
Publikováno v:
Physics in Medicine & Biology.
Objective:The TOPAS-nBio Monte Carlo track structure simulation code, a wrapper of Geant4-DNA, was extended for its use in pulsed and longtime homogeneous chemistry simulations using the Gillespie algorithm. Approach: Three different tests were used
Autor:
Qixian Zhang, Leo E. Gerweck, Ethan Cascio, Liqun Gu, Qingyuan Yang, Xinyue Dong, Peigen Huang, Alejandro Bertolet, Konrad Pawel Nesteruk, Wonmo Sung, Aimee L. McNamara, Jan Schuemann
Publikováno v:
Cancers; Volume 15; Issue 8; Pages: 2269
Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional dose rate irradiation. This tissue sparing has been termed the FLASH effect. We investigated the FLASH effect of proton irradiation on the intestine a
Autor:
Wei Zou, Rongxiao Zhang, Emil Schueler, Paige A Taylor, Anthony E Mascia, Eric S Diffenderfer, Tianyu Zhao, Ahmet S Ayan, Manju Sharma, Shu-Jung Yu, Weiguo Lu, Walter R Bosch, Christina Tsien, Murat Surucu, Julianne M Pollard-Larkin, Jan Schuemann, Eduardo G Moros, Magdalena Bazalova-Carter, David J Gladstone, Heng Li, Charles B Simone, Kristoffer Petersson, Stephen F Kry, Amit Maity, Billy W Loo, Lei Dong, Peter G Maxim, Ying Xiao, Jeffrey C Buchsbaum
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics.