Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jan Schmidt-Mende"'
Publikováno v:
Rheumatology (Oxford, England). 60(7)
ObjectivesStudies on repeat renal biopsies in membranous LN (MLN) are limited, and evaluation of treatment response is mainly based on proteinuria. EM of renal biopsies from rituximab (RTX)-treated MLN patients has revealed resorption of sub-epitheli
Publikováno v:
Journal of immunological methods
Neutrophils are terminally differentiated cells with a short life-span due to constitutive apoptosis. Because of these characteristics, genetic manipulation of neutrophils has been difficult, although it is highly desired given the importance of neut
Autor:
Bengt Fadeel, Ramin Tehranchi, Robert Hast, Jan Schmidt-Mende, Martin Jädersten, Eva Hellström-Lindberg, Robert B. Howe, Ann-Mari Forsblom, Emma K. Emanuelsson, Boris Zhivotovsky, Birger Christensson, Jan Samuelsson
Publikováno v:
Clinical Cancer Research. 11:6291-6299
Purpose: Erythroid apoptosis in low-risk myelodysplastic syndrome (MDS) maybe mediated via mitochondrial release of cytochrome c and subsequent caspase activation. In the present study, we compared the in vitro and in vivo effects of proerythroid tre
Autor:
Jan Schmidt-Mende, Boris Zhivotovsky, Eva Hellström Lindberg, A.-M. Forsblom, Bengt Fadeel, Birger Christensson
Publikováno v:
British Journal of Haematology. 112:714-726
Treatment with granulocyte colony-stimulating factor plus erythropoietin may improve haemoglobin levels in patients with ringsideroblastic anaemia (RARS) and reduce bone marrow apoptosis. We studied bone marrow from 10 RARS patients, two of whom were
Publikováno v:
Oncoimmunology
Arginase 1 (ARG1) is an important enzyme in amino acid metabolism that also exerts immunoregulatory function. High ARG1 expression, which is associated with cell cycle arrest and functional unresponsiveness in T cells, has been observed after trauma,
Autor:
Arezoo Daryadel, Carlo Mordasini, Inès Schmid, Hans-Uwe Simon, Andrew Ziemiecki, Clemens A. Dahinden, David Troi, Jan Schmidt-Mende, Shida Yousefi
Publikováno v:
Journal of immunology (Baltimore Md. : 1950)
Journal of Immunology
Journal of Immunology
Leukotriene B4 (LTB4) is an important proinflammatory lipid mediator generated by neutrophils upon activation. GM-CSF stimulation is known to enhance agonist-mediated LTB4 production of neutrophils within minutes, a process called “priming”. In t
Autor:
Svetlana A. Didichenko, Jan Schmidt-Mende, Nicola Andina, Hans-Uwe Simon, Clemens A. Dahinden
Publikováno v:
The Journal of allergy and clinical immunology. 123(3)
Background Eosinophil differentiation, activation, and survival are largely regulated by IL-5. IL-5–mediated transmembrane signal transduction involves both Lyn–mitogen-activated protein kinases and Janus kinase 2–signal transducer and activato
Autor:
Tomas J. Ekström, Rasheed Khan, Jan Schmidt-Mende, Moustapha Hassan, Vladimir Gogvadze, Boris Zhivotovsky, Eva Hellström-Lindberg, Mohsen Karimi
Publikováno v:
Experimental hematology. 36(2)
Objective Although clinically approved for myelodysplastic syndromes (MDS), the mode of action of 5-azacytidine has not been well understood at the cellular level. The present study aimed at characterizing the mechanisms for 5-azacytidine–induced a
Publikováno v:
Cell death and differentiation. 13(1)
All-trans retinoic acid (ATRA) induces differentiation and subsequent apoptosis in a variety of cell lines. Using the myeloid cell line P39, we show that ATRA disturbs mitochondrial functional activity long before any detectable signs of apoptosis oc
Autor:
Boris Zhivotovsky, Jan Schmidt-Mende
Publikováno v:
Scopus-Elsevier
Commentary to: Expression of Inducible Bcl-XS in Myeloid Leukemia: Compensatory Upregulation of Bcl-XL and Bcl-2 Prevents Apoptosis and Chemosensitization Frank Tacke, Frank C. Marini, III, Shourong Zhao, Teresa McQueen, Marina Konopleva, Peter P. Ru