Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jan S Tchorz"'
Autor:
Jan S Tchorz, Thomas Suply, Iwona Ksiazek, Claudio Giachino, Dimitri Cloëtta, Claus-Peter Danzer, Thierry Doll, Andrea Isken, Marianne Lemaistre, Verdon Taylor, Bernhard Bettler, Bernd Kinzel, Matthias Mueller
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30011 (2012)
Generation of gain-of-function transgenic mice by targeting the Rosa26 locus has been established as an alternative to classical transgenic mice produced by pronuclear microinjection. However, targeting transgenes to the endogenous Rosa26 promoter re
Externí odkaz:
https://doaj.org/article/d25336e0939a49ddbdb49a78de491c5a
Autor:
Xiuxiu Liu, Maoying Han, Wendong Weng, Yan Li, Wenjuan Pu, Kuo Liu, Xufeng Li, Lingjuan He, Ruilin Sun, Ruling Shen, Yulong He, Dandan Liang, Yi-Han Chen, Qing-Dong Wang, Jan S. Tchorz, Bin Zhou
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-7 (2023)
Abstract A genetic system, ProTracer, has been recently developed to record cell proliferation in vivo. However, the ProTracer is initiated by an infrequently used recombinase Dre, which limits its broad application for functional studies employing f
Externí odkaz:
https://doaj.org/article/003857d550184788a930ee3f005fbb6c
Publikováno v:
JHEP Reports, Vol 5, Iss 8, Pp 100779- (2023)
Summary: The process of metabolic liver zonation is spontaneously established by assigning distributed tasks to hepatocytes along the porto-central blood flow. Hepatocytes fulfil critical metabolic functions, while also maintaining hepatocyte mass by
Externí odkaz:
https://doaj.org/article/7dd3870b7df1449eb677ddd96ce0060c
Autor:
Atanu Paul, Stefano Annunziato, Bo Lu, Tianliang Sun, Olivera Evrova, Lara Planas-Paz, Vanessa Orsini, Luigi M. Terracciano, Olga Charlat, Zinger Yang Loureiro, Lei Ji, Raffaella Zamponi, Frederic Sigoillot, Hong Lei, Alicia Lindeman, Carsten Russ, John S. Reece-Hoyes, Thomas B. Nicholson, Jan S. Tchorz, Feng Cong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
How cell-cell contact is sensed by Hippo pathway is poorly understood. Here, the authors show that KIRREL1 functions as a feedback regulator of the mammalian Hippo pathway by sensing cell-cell interaction and recruiting SAV1 to cell-cell contacts.
Externí odkaz:
https://doaj.org/article/bfe690555e05477e9caae7da26bcc89a
Autor:
Lei Ji, Bo Lu, Raffaella Zamponi, Olga Charlat, Robert Aversa, Zinger Yang, Frederic Sigoillot, Xiaoping Zhu, Tiancen Hu, John S. Reece-Hoyes, Carsten Russ, Gregory Michaud, Jan S. Tchorz, Xiaomo Jiang, Feng Cong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Axin is a scaffolding protein known for its role in Wnt signalling that can be marked with a variety of post-translational modifications. Here, Cong et al. demonstrate that USP7 de-ubiquinates Axin and that canonical Wnt signaling output can be incre
Externí odkaz:
https://doaj.org/article/c0ce8720c63e468a9e5f72379fe211b1
Autor:
Wenjuan Pu, Huan Zhu, Mingjun Zhang, Monika Pikiolek, Caner Ercan, Jie Li, Xiuzhen Huang, Ximeng Han, Zhenqian Zhang, Zan Lv, Yan Li, Kuo Liu, Lingjuan He, Xiuxiu Liu, Markus H. Heim, Luigi M. Terracciano, Jan S. Tchorz, Bin Zhou
Publikováno v:
Nature Genetics. 55:651-664
Following severe liver injury, when hepatocyte-mediated regeneration is impaired, biliary epithelial cells (BECs) can transdifferentiate into functional hepatocytes. However, the subset of BECs with such facultative tissue stem cell potential, as wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cd6ea7a076a9477e14fcd9e6887473c
https://doi.org/10.1038/s41588-023-01335-9
https://doi.org/10.1038/s41588-023-01335-9
Publikováno v:
Hepatology. 76:888-899
WNT/β-catenin signaling plays pivotal roles during liver development, homeostasis, and regeneration. Likewise, its deregulation disturbs metabolic liver zonation and is responsible for the development of a large number of hepatic tumors. Liver fibro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bacfee87b42587bffabd426c5fa4ac6
https://doi.org/10.1002/hep.32328
https://doi.org/10.1002/hep.32328
Autor:
Jan S, Tchorz
Publikováno v:
Hepatology. 76:1557-1559
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b262aeb599e2ae6ce1eb80153a1b7c8e
https://doi.org/10.1002/hep.32513
https://doi.org/10.1002/hep.32513
Autor:
Wenjuan Pu, Huan Zhu, Mingjun Zhang, Monika Pikiolek, Caner Ercan, Jie Li, Xiuzhen Huang, Ximeng Han, Zhenqian Zhang, Zan Lv, Yan Li, Kuo Liu, Lingjuan He, Xiuxiu Liu, Markus H. Heim, Luigi M. Terracciano, Jan S. Tchorz, Bin Zhou
Publikováno v:
Nature Genetics. 55:892-892
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0da3ae7c878d11ea45f600b8ea4bb0a
https://doi.org/10.1038/s41588-023-01393-z
https://doi.org/10.1038/s41588-023-01393-z
Autor:
Feng Chen, Jan S. Tchorz
Publikováno v:
Cell stem cell. 29(6)
In this issue, Ben-Moshe et al. (2022) use spatiotemporally resolved single-cell and spatial transcriptomic profiling to dissect the multicellular dynamics enabling zonal liver regeneration. They highlight how pan-zonal compensatory hepatocyte prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e818fd18c68be5cdf461cb75b36f9951
https://pubmed.ncbi.nlm.nih.gov/35659879
https://pubmed.ncbi.nlm.nih.gov/35659879