Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Jan Rothuizen"'
Autor:
Giora van Straten, Diewke vanDalen, Sietske J. Mesu, Jan Rothuizen, Erik Teske, Bart Spee, Robert P. Favier, Ingeborg M. vanGeijlswijk
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 33, Iss 3, Pp 1331-1335 (2019)
Abstract Background Hyperammonemia can result in hepatic encephalopathy, which in severe cases eventually can lead to coma and death. In dogs, congenital portosystemic shunts (CPSS) are the most common cause for hyperammonemia. Conservative treatment
Externí odkaz:
https://doaj.org/article/4bf6544365344e0ebaec58608486d724
Autor:
Chiara Valtolina, Arie B. Vaandrager, Robert P. Favier, Maidina Tuohetahuntila, Anne Kummeling, Isabelle Jeusette, Jan Rothuizen, Joris H. Robben
Publikováno v:
BMC Veterinary Research, Vol 13, Iss 1, Pp 1-9 (2017)
Abstract Background A link between lipid metabolism and disease has been recognized in cats. Since hepatic lipidosis is a frequent disorder in cats, the aim of the current study was to evaluate liver and plasma lipid dimorphism in healthy cats and th
Externí odkaz:
https://doaj.org/article/0ff357aca8bb476eae48394713a7a191
Autor:
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Ingrid G.W.H. Vernooij, Ingrid M. Schrall, Monique E. van Wolferen, Farah Bannink, Camille Roesch, Lisa van Uden, Martijn R. Molenaar, J. Bernd Helms, Guy C.M. Grinwis, Monique M.A. Verstegen, Luc J.W. van der Laan, Meritxell Huch, Niels Geijsen, Robert G. Vries, Hans Clevers, Jan Rothuizen, Baukje A. Schotanus, Louis C. Penning, Bart Spee
Publikováno v:
Stem Cell Reports, Vol 8, Iss 4, Pp 822-830 (2017)
Summary: Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure. Previous studies demonstrate the p
Externí odkaz:
https://doaj.org/article/1b75311bbf3843328b88a26d9590e37a
Autor:
Hille Fieten, Yadvinder Gill, Alan J. Martin, Mafalda Concilli, Karen Dirksen, Frank G. van Steenbeek, Bart Spee, Ted S. G. A. M. van den Ingh, Ellen C. C. P. Martens, Paola Festa, Giancarlo Chesi, Bart van de Sluis, Roderick H. J. H. Houwen, Adrian L. Watson, Yurii S. Aulchenko, Victoria L. Hodgkinson, Sha Zhu, Michael J. Petris, Roman S. Polishchuk, Peter A. J. Leegwater, Jan Rothuizen
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 1, Pp 25-38 (2016)
The deleterious effects of a disrupted copper metabolism are illustrated by hereditary diseases caused by mutations in the genes coding for the copper transporters ATP7A and ATP7B. Menkes disease, involving ATP7A, is a fatal neurodegenerative disorde
Externí odkaz:
https://doaj.org/article/ed1cab5637da4a468e9d141775e641c2
Autor:
Sathidpak Nantasanti, Bart Spee, Hedwig S. Kruitwagen, Chen Chen, Niels Geijsen, Loes A. Oosterhoff, Monique E. van Wolferen, Nicolas Pelaez, Hille Fieten, Richard W. Wubbolts, Guy C. Grinwis, Jefferson Chan, Meritxell Huch, Robert R.G. Vries, Hans Clevers, Alain de Bruin, Jan Rothuizen, Louis C. Penning, Baukje A. Schotanus
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 895-907 (2015)
The recent development of 3D-liver stem cell cultures (hepatic organoids) opens up new avenues for gene and/or stem cell therapy to treat liver disease. To test safety and efficacy, a relevant large animal model is essential but not yet established.
Externí odkaz:
https://doaj.org/article/1abf448ce02c4f37b5e21cdc6b0ded40
Autor:
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Monique E. van Wolferen, Chen Chen, Sathidpak Nantasanti Assawarachan, Kerstin Schneeberger, Anne Kummeling, Giora van Straten, Ies C. Akkerdaas, Christel R. Vinke, Frank G. van Steenbeek, Leonie W.L. van Bruggen, Jeannette Wolfswinkel, Guy C.M. Grinwis, Sabine A. Fuchs, Helmuth Gehart, Niels Geijsen, Robert G. Vries, Hans Clevers, Jan Rothuizen, Baukje A. Schotanus, Louis C. Penning, Bart Spee
Publikováno v:
Cells, Vol 9, Iss 2, p 410 (2020)
The shortage of liver organ donors is increasing and the need for viable alternatives is urgent. Liver cell (hepatocyte) transplantation may be a less invasive treatment compared with liver transplantation. Unfortunately, hepatocytes cannot be expand
Externí odkaz:
https://doaj.org/article/c674d01025924804a5b649c947eca488
Autor:
Lindsay Van den Bossche, Vivien A C Schoonenberg, Iwan A Burgener, Louis C Penning, Ingrid M Schrall, Hedwig S Kruitwagen, Monique E van Wolferen, Guy C M Grinwis, Anne Kummeling, Jan Rothuizen, Jeroen F van Velzen, Nikolas Stathonikos, Martijn R Molenaar, Bernd J Helms, Jos F H M Brouwers, Bart Spee, Frank G van Steenbeek
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186491 (2017)
Non-alcoholic fatty liver disease (NAFLD) is a poorly understood multifactorial pandemic disorder. One of the hallmarks of NAFLD, hepatic steatosis, is a common feature in canine congenital portosystemic shunts. The aim of this study was to gain deta
Externí odkaz:
https://doaj.org/article/d24b3c0da950484b9acfde4701c548bc
Autor:
Karen Dirksen, Bart Spee, Louis C Penning, Ted S G A M van den Ingh, Iwan A Burgener, Adrian L Watson, Marian Groot Koerkamp, Jan Rothuizen, Frank G van Steenbeek, Hille Fieten
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176826 (2017)
Copper is an essential trace element, but can become toxic when present in abundance. The severe effects of copper-metabolism imbalance are illustrated by the inherited disorders Wilson disease and Menkes disease. The Labrador retriever dog breed is
Externí odkaz:
https://doaj.org/article/155dbf7dcdcf4302b3c3d9be1711c65e
Publikováno v:
European Medical Journal Hepatology, Vol 1, Iss 1, Pp 78-84 (2013)
The current ‘state-of-the-art’ molecular techniques are extremely sensitive and consequently prone to false results. Even more so than in the past, today’s hepatology research depends on high quality samples, especially for the molecular analys
Externí odkaz:
https://doaj.org/article/3d3c0634e16a47beb0a8b071a5272f77
Autor:
Giora van Straten, Frank G van Steenbeek, Guy C M Grinwis, Robert P Favier, Anne Kummeling, Ingrid H van Gils, Hille Fieten, Marian J A Groot Koerkamp, Frank C P Holstege, Jan Rothuizen, Bart Spee
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100077 (2014)
The detoxification of ammonia occurs mainly through conversion of ammonia to urea in the liver via the urea cycle and glutamine synthesis. Congenital portosystemic shunts (CPSS) in dogs cause hyperammonemia eventually leading to hepatic encephalopath
Externí odkaz:
https://doaj.org/article/7ede9a910425447ebd39719c1003e49c