Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Jan Rossaint"'
Autor:
Jonas Goretzko, Inga Pauels, Nicole Heitzig, Katharina Thomas, Marina Kardell, Johannes Naß, Einar Kleinhans Krogsaeter, Sebastian Schloer, Barbara Spix, Anna Lívia Linard Matos, Charlotte Leser, Tristan Wegner, Frank Glorius, Franz Bracher, Volker Gerke, Jan Rossaint, Christian Grimm, Ursula Rescher
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113501- (2023)
Summary: Upon proinflammatory challenges, endothelial cell surface presentation of the leukocyte receptor P-selectin, together with the stabilizing co-factor CD63, is needed for leukocyte capture and is mediated via demand-driven exocytosis from the
Externí odkaz:
https://doaj.org/article/743e166b584b4ba9a9ee505a123e92b3
Autor:
Nadine Ludwig, Julia Thörner-van Almsick, Sina Mersmann, Bernadette Bardel, Silke Niemann, Achmet Imam Chasan, Michael Schäfers, Andreas Margraf, Jan Rossaint, Barbara C. Kahl, Alexander Zarbock, Helena Block
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Staphylococcus aureus is a common cause of hospital-acquired pneumonia associated with high mortality. Adequate clinical treatment is impeded by increasing occurrence of antibiotic resistances. Understanding the underlying mechanisms of its virulence
Externí odkaz:
https://doaj.org/article/88d8f9b500314d4da840947d6dce8206
Autor:
Katharina Thomas, Lisa Zondler, Nadine Ludwig, Marina Kardell, Corinna Lüneburg, Katharina Henke, Sina Mersmann, Andreas Margraf, Tilmann Spieker, Tobias Tekath, Ana Velic, Richard Holtmeier, Juliane Hermann, Vera Jankowski, Melanie Meersch, Dietmar Vestweber, Martin Westphal, Johannes Roth, Michael A. Schäfers, John A. Kellum, Clifford A. Lowell, Jan Rossaint, Alexander Zarbock
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
Acute kidney injury (AKI) represents a common complication in critically ill patients that is associated with increased morbidity and mortality. In a murine AKI model induced by ischemia/reperfusion injury (IRI), we show that glutamine significantly
Externí odkaz:
https://doaj.org/article/30ea337b9c5d4c7ea8eab77560c841db
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Platelets are well characterized for their indispensable role in primary hemostasis to control hemorrhage. Research over the past years has provided a substantial body of evidence demonstrating that platelets also participate in host innate immunity.
Externí odkaz:
https://doaj.org/article/b4d566bfe06848d59bbf488e55248107
Autor:
Jan Rossaint, Melanie Meersch, Katharina Thomas, Sina Mersmann, Martin Lehmann, Jennifer Skupski, Tobias Tekath, Peter Rosenberger, John A. Kellum, Hermann Pavenstädt, Alexander Zarbock
Publikováno v:
JCI Insight, Vol 7, Iss 14 (2022)
Acute kidney injury increases morbidity and mortality, and previous studies have shown that remote ischemic preconditioning (RIPC) reduces the risk of acute kidney injury after cardiac surgery. RIPC increases urinary high mobility group box protein-1
Externí odkaz:
https://doaj.org/article/5b4605dd23ba458f874aefa40181f27b
Autor:
Alexandros Rovas, Jan Sackarnd, Jan Rossaint, Stefanie Kampmeier, Hermann Pavenstädt, Hans Vink, Philipp Kümpers
Publikováno v:
Critical Care, Vol 25, Iss 1, Pp 1-14 (2021)
Abstract Background The availability of handheld, noninvasive sublingual video-microscopes allows for visualization of the microcirculation in critically ill patients. Recent studies demonstrate that reduced numbers of blood-perfused microvessels and
Externí odkaz:
https://doaj.org/article/5c56cbd523844196a9c4b83fd1c48765
Autor:
Saskia-Larissa Jauch-Speer, Marisol Herrera-Rivero, Nadine Ludwig, Bruna Caroline Véras De Carvalho, Leonie Martens, Jonas Wolf, Achmet Imam Chasan, Anika Witten, Birgit Markus, Bernhard Schieffer, Thomas Vogl, Jan Rossaint, Monika Stoll, Johannes Roth, Olesja Fehler
Publikováno v:
eLife, Vol 11 (2022)
The proinflammatory alarmins S100A8 and S100A9 are among the most abundant proteins in neutrophils and monocytes but are completely silenced after differentiation to macrophages. The molecular mechanisms of the extraordinarily dynamic transcriptional
Externí odkaz:
https://doaj.org/article/54c2d245beda43d9b5ba5bca2657fa7e
Autor:
Zhenhan Li, Nadine Ludwig, Katharina Thomas, Sina Mersmann, Martin Lehmann, Dietmar Vestweber, Jean-Francois Pittet, Hernando Gomez, John A. Kellum, Jan Rossaint, Alexander Zarbock
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Acute kidney injury (AKI) may be induced by different causes, including renal ischemia-reperfusion injury and sepsis, which represent the most common reasons for AKI in hospitalized patients. AKI is defined by reduced urine production and/or increase
Externí odkaz:
https://doaj.org/article/643a80cce42f42a292654931518c71c2
Autor:
Julian Revenstorff, Nadine Ludwig, Annika Hilger, Sina Mersmann, Martin Lehmann, Julia Chiara Grenzheuser, Marina Kardell, Julia Bone, Niklas Martin Kötting, Nina Christine Marx, Johannes Roth, Thomas Vogl, Jan Rossaint
Publikováno v:
Cells, Vol 11, Iss 23, p 3944 (2022)
Acute respiratory distress syndrome (ARDS) due to pulmonary infections is associated with high morbidity and mortality. Upon inflammation, the alarmin S100A8/A9 is released and stimulates neutrophil recruitment mainly via binding to Toll-like recepto
Externí odkaz:
https://doaj.org/article/a6ee692518b84566959593a56bfa9f03
Publikováno v:
Cells, Vol 11, Iss 12, p 1919 (2022)
The innate immune system is the first line of defense against invading pathogens or sterile injuries. Pattern recognition receptors (PRR) sense molecules released from inflamed or damaged cells, or foreign molecules resulting from invading pathogens.
Externí odkaz:
https://doaj.org/article/1361a868bfc2460e9f9d95d8e15d2852