Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Jan Riemer"'
Autor:
Christine Zarges, Jan Riemer
Publikováno v:
FEBS Open Bio, Vol 14, Iss 10, Pp 1610-1626 (2024)
The mitochondrial intermembrane space hosts a machinery for oxidative protein folding, the mitochondrial disulfide relay. This machinery imports a large number of soluble proteins into the compartment, where they are retained through oxidative foldin
Externí odkaz:
https://doaj.org/article/dc1a5264de194e0ea296acc13bd27e81
Autor:
Maithily S. Nanadikar, Ana M. Vergel Leon, Jia Guo, Gijsbert J. van Belle, Aline Jatho, Elvina S. Philip, Astrid F. Brandner, Rainer A. Böckmann, Runzhu Shi, Anke Zieseniss, Carla M. Siemssen, Katja Dettmer, Susanne Brodesser, Marlen Schmidtendorf, Jingyun Lee, Hanzhi Wu, Cristina M. Furdui, Sören Brandenburg, Joseph R. Burgoyne, Ivan Bogeski, Jan Riemer, Arpita Chowdhury, Peter Rehling, Tobias Bruegmann, Vsevolod V. Belousov, Dörthe M. Katschinski
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Redox signaling and cardiac function are tightly linked. However, it is largely unknown which protein targets are affected by hydrogen peroxide (H2O2) in cardiomyocytes that underly impaired inotropic effects during oxidative stress. Here, w
Externí odkaz:
https://doaj.org/article/46b0dc091943496094992a4e0a96de5f
Autor:
Ira Buntenbroich, Vincent Anton, Daniel Perez-Hernandez, Tânia Simões, Felix Gaedke, Astrid Schauss, Gunnar Dittmar, Jan Riemer, Mafalda Escobar-Henriques
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107014- (2023)
Summary: Defects in mitochondrial fusion are at the base of many diseases. Mitofusins power membrane-remodeling events via self-interaction and GTP hydrolysis. However, how exactly mitofusins mediate fusion of the outer membrane is still unclear. Str
Externí odkaz:
https://doaj.org/article/2eefab8f7d994a5ba3d1157baf69c35f
Autor:
Johannes CW Hermeling, Marija Herholz, Linda Baumann, Estela Cepeda Cores, Aleksandra Zečić, Thorsten Hoppe, Jan Riemer, Aleksandra Trifunovic
Publikováno v:
Redox Biology, Vol 58, Iss , Pp 102533- (2022)
Alternations of redox metabolism have been associated with the extension of lifespan in roundworm Caenorhabditis elegans, caused by moderate mitochondrial dysfunction, although the underlying signalling cascades are largely unknown. Previously, we id
Externí odkaz:
https://doaj.org/article/b431503942404f30838c5e9c463607a3
Publikováno v:
Bio-Protocol, Vol 12, Iss 20 (2022)
Depending on its local concentration, hydrogen peroxide (H2O2) can serve as a cellular signaling molecule but can also cause damage to biomolecules. The levels of H2O2 are influenced by the activity of its generator sites, local antioxidative systems
Externí odkaz:
https://doaj.org/article/90d7210ee4e04af79fe8a24056e206f1
Autor:
Christina M. Bebber, Emily S. Thomas, Jenny Stroh, Zhiyi Chen, Ariadne Androulidaki, Anna Schmitt, Michaela N. Höhne, Lukas Stüker, Cleidson de Pádua Alves, Armin Khonsari, Marcel A. Dammert, Fatma Parmaksiz, Hannah L. Tumbrink, Filippo Beleggia, Martin L. Sos, Jan Riemer, Julie George, Susanne Brodesser, Roman K. Thomas, H. Christian Reinhardt, Silvia von Karstedt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The high degree of subtype plasticity in small cell lung cancer (SCLC) poses a therapeutic challenge. Here, the authors show that the non-neuroendocrine (non-NE) subtype of SCLC is sensitive to ferroptosis while the neuroendocrine (NE) subtype is vul
Externí odkaz:
https://doaj.org/article/72d102a3804747f8993f740dde35ff92
Autor:
Lena Maria Murschall, Anne Gerhards, Thomas MacVicar, Esra Peker, Lidwina Hasberg, Stephan Wawra, Thomas Langer, Jan Riemer
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background The mitochondrial intermembrane space (IMS) is home to proteins fulfilling numerous essential cellular processes, particularly in metabolism and mitochondrial function. All IMS proteins are nuclear encoded and synthesized in the c
Externí odkaz:
https://doaj.org/article/ac80c697835b478d9e9f982bb94a3a41
Autor:
Karolina Szczepanowska, Katharina Senft, Juliana Heidler, Marija Herholz, Alexandra Kukat, Michaela Nicole Höhne, Eduard Hofsetz, Christina Becker, Sophie Kaspar, Heiko Giese, Klaus Zwicker, Sergio Guerrero-Castillo, Linda Baumann, Johanna Kauppila, Anastasia Rumyantseva, Stefan Müller, Christian K. Frese, Ulrich Brandt, Jan Riemer, Ilka Wittig, Aleksandra Trifunovic
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Maintenance and quality control of the mitochondrial respiratory chain complexes responsible for bulk energy production are unclear. Here, the authors show that the mitochondrial protease ClpXP is required for the rapid turnover of the core N-module
Externí odkaz:
https://doaj.org/article/1441c467d7c84761ba914e66d3b9d5a7
Publikováno v:
Bio-Protocol, Vol 11, Iss 12 (2021)
Mitochondria are essential organelles containing approximately 1,500 proteins. Only approximately 1% of these proteins are synthesized inside mitochondria, whereas the remaining 99% are synthesized as precursors on cytosolic ribosomes and imported in
Externí odkaz:
https://doaj.org/article/e9089280ba444a248392b2c9002dafd4
Autor:
Alican J. Erdogan, Muna Ali, Markus Habich, Silja L. Salscheider, Laura Schu, Carmelina Petrungaro, Luke W. Thomas, Margaret Ashcroft, Lars I. Leichert, Leticia Prates Roma, Jan Riemer
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 200-206 (2018)
Disulfide formation in the mitochondrial intermembrane space is an essential process catalyzed by a disulfide relay machinery. In mammalian cells, the key enzyme in this machinery is the oxidoreductase CHCHD4/Mia40. Here, we determined the in vivo CH
Externí odkaz:
https://doaj.org/article/f2e43501c2324dcab863d4394c5c4fdf