Výsledky vyhledávání - "Jan R. Flynn"

Hemicholinium-3 congeners as potential antagonists to organophosphate-induced toxicity

Autor: M. F. Sahin, Raj K. Bhatnagar, John P. Long, Jan R. Flynn, Joseph G. Cannon

Publikováno v: Journal of Medicinal Chemistry. 33:577-579

A series of congeners of hemicholinium-3, in which the 1,4-oxazinium rings of hemicholinium are replaced by pyrrolidine, piperidine, 1,3-dioxane, or 1,4-oxazine rings, is described. Several of the target compounds produced blockade of neuromuscular t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafdf934b65b39f4c82fb2a6460deb06
https://doi.org/10.1021/jm00164a017

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Comparison of biological effects of N-alkylated congeners of .beta.-phenethylamine derived from 2-aminotetralin, 2-aminoindan, and 6-aminobenzocycloheptene

Autor: John P. Long, Jan R. Flynn, Jonathan P. Pease, Stuart E. Dryer, David B. Rusterholz, Joseph G. Cannon, Julio A. Perez

Publikováno v: Journal of Medicinal Chemistry. 23:745-749

Three series of bicyclic, semirigid congeners of beta-phenethylamine have been prepared for evaluation of the effect of ring size (and of concomitant conformational variation) on biological activity in a variety of assays for adrenergic and dopaminer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e9a187570351d80dee24ee4af96f73
https://doi.org/10.1021/jm00181a009

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Congeners of the .beta. conformer of dopamine derived from cis- and trans-octahydrobenzo[f]quinoline and trans-octahydrobenzo[g]quinoline

Autor: Brenda Costall, H. Duane Goldman, Teresa Lee, John P. Long, Turkiz Verimer, Joseph G. Cannon, Robert J. Naylor, Jan R. Flynn

Publikováno v: Journal of Medicinal Chemistry. 23:1-5

The so-called beta conformer of dopamine has been proposed to be involved in agonist--receptor interactions at several sites in the dopaminergic nervous system. Further to evaluate this proposal, rigid congeners of the beta conformer derived from lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ac9374cd24253a8fee09ee7ff010cb
https://doi.org/10.1021/jm00175a001

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Antagonist properties of phentolamine at both presynaptic α2-adrenoceptors and presynaptic dopamine receptors using field stimulated right cat atria

Autor: Jay C. Koons, Jan R. Flynn, John P. Long

Publikováno v: European Journal of Pharmacology. 88:311-317

Phentolamine, which is considered a specific alpha-adrenoceptor antagonist, was tested for antagonist properties at presynaptic dopamine receptors and presynaptic alpha 2-adrenoceptors present on sympathetic nerve terminals in isolated right cat atri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd33116c06108754865858a42282477f
https://doi.org/10.1016/0014-2999(83)90581-2

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Preparation and biological actions of some symmetrically N,N-disubstituted dopamines

Autor: Robert J. Naylor, John P. Long, Joseph G. Cannon, Fu-Lian Hsu, Jan R. Flynn, Brenda Costall

Publikováno v: Journal of Medicinal Chemistry. 21:248-253

The title compounds have been synthesized and evaluated for emetic effects in the dog, actions on the cardioaccelerator nerve in the cat, pecking in pigeons, and for behavioral effects following both peripheral and direct intracerebral injection into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace673d463712e7516916f97b0e8eae1
https://doi.org/10.1021/jm00201a002

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Introduction of a putative dopaminergic prodrug moiety into a 6,7-substitution pattern characteristic of certain 2-aminotetralin dopaminergic agonists

Autor: Ranbir K. Bhatnagar, Joseph G. Cannon, John P. Long, Jan R. Flynn, Claire Diane True, Paul A. Leonard

Publikováno v: Journal of Medicinal Chemistry. 32:2210-2214

On the basis of the premise that the dopaminergic agonist profile of 2-(di-n-propylamino)-5-hydroxy-6-methyltetralin (1a) is due to in vivo oxidation of the 6-methyl moiety and that 1a may represent a novel prodrug strategy, the vicinal methyl-hydrox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e916a049ac04eb0c2c824d925f60e16
https://doi.org/10.1021/jm00129a029

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5,7-Dihydroxy-2-aminotetralin derivatives: synthesis and assessment of dopaminergic and adrenergic actions

Autor: Brenda Costall, John P. Long, A. N. Brubaker, Jan R. Flynn, T. Verimer, Robert J. Naylor, Joseph G. Cannon, Peerarat Harnirattisai, V. Nohria

Publikováno v: Journal of Medicinal Chemistry. 24:149-153

Replacement of the catechol 3,4-dihydroxylation pattern of certain adrenergic beta-phenethylamines by a resorcinol 3,5-dihydroxylation pattern has led to a greater selectivity of adrenergic agonist effects in certain molecules. This strategy has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df888c65a8f0e2f8b05a69a4e696ee8
https://doi.org/10.1021/jm00134a005

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Dopaminergic effects of non-hydroxylated rigid analogs of apomorphine

Autor: Frank P. Bymaster, James A. Clemens, David B. Rusterholz, Teresa Lee, Jonathan P. Pease, David T. Wong, John P. Long, Jan R. Flynn, Joseph G. Cannon

Publikováno v: European Journal of Pharmacology. 55:73-82

A series of rigid analogs of apomorphine lacking aromatic hydroxyl substituents were evaluated for dopaminergic properties. Three compounds, N-methyl-N-propyl-2-aminotetralin (Me-Pr-2-AT), N, N-dipropyl-2-aminotetralin (Di-Pr-2-AT) and N, N-dipropyl-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e0ce7dba6acabe76b5c375078e8b38
https://doi.org/10.1016/0014-2999(79)90149-3

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