Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Jan Pravsgaard Christensen"'
Autor:
Jinglin Zhou, Ida Uddback, Jacob E. Kohlmeier, Jan Pravsgaard Christensen, Allan Randrup Thomsen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMucosal immunization eliciting local T-cell memory has been suggested for improved protection against respiratory infections caused by viral variants evading pre-existing antibodies. However, it remains unclear whether T-cell targeted vac
Externí odkaz:
https://doaj.org/article/2f6df0d634574b2f8b7ce35430728a82
Autor:
Egle Paskeviciute, Mei Chen, Heping Xu, Bent Honoré, Henrik Vorum, Torben Lykke Sørensen, Jan Pravsgaard Christensen, Allan Randrup Thomsen, Mogens Holst Nissen, Maria Abildgaard Steffensen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
During recent years, evidence has emerged that immune privileged sites such as the CNS and the retina may be more integrated in the systemic response to infection than was previously believed. In line with this, it was recently shown that a systemic
Externí odkaz:
https://doaj.org/article/30457082d32b4a29a6d668c4dc46358f
Autor:
Anna Offersgaard, Carlos Rene Duarte Hernandez, Shan Feng, Pavel Marichal-Gallardo, Kenn Holmbeck, Anne Finne Pihl, Carlota Fernandez-Antunez, Garazi Peña Alzua, Katrine Top Hartmann, Long V. Pham, Yuyong Zhou, Karen Anbro Gammeltoft, Ulrik Fahnøe, Uffe Vest Schneider, Gabriel Kristian Pedersen, Henrik Elvang Jensen, Jan Pravsgaard Christensen, Santseharay Ramirez, Jens Bukh, Judith Margarete Gottwein
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105949- (2023)
Summary: Vaccines have relieved the public health burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and globally inactivated vaccines are most widely used. However, poor vaccination accessibility and waning immunity maintain the
Externí odkaz:
https://doaj.org/article/5be313e70944483e85a0601f5bf5dfe3
Autor:
Cyrielle Fougeroux, Louise Goksøyr, Manja Idorn, Vladislav Soroka, Sebenzile K. Myeni, Robert Dagil, Christoph M. Janitzek, Max Søgaard, Kara-Lee Aves, Emma W. Horsted, Sayit Mahmut Erdoğan, Tobias Gustavsson, Jerzy Dorosz, Stine Clemmensen, Laurits Fredsgaard, Susan Thrane, Elena E. Vidal-Calvo, Paul Khalifé, Thomas M. Hulen, Swati Choudhary, Michael Theisen, Susheel K. Singh, Asier Garcia-Senosiain, Linda Van Oosten, Gorben Pijlman, Bettina Hierzberger, Tanja Domeyer, Blanka W. Nalewajek, Anette Strøbæk, Magdalena Skrzypczak, Laura F. Andersson, Søren Buus, Anette Stryhn Buus, Jan Pravsgaard Christensen, Tim J. Dalebout, Kasper Iversen, Lene H. Harritshøj, Benjamin Mordmüller, Henrik Ullum, Line S. Reinert, Willem Adriaan de Jongh, Marjolein Kikkert, Søren R. Paludan, Thor G. Theander, Morten A. Nielsen, Ali Salanti, Adam F. Sander
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Here the authors generate a capsid-like particle based vaccine candidate displaying the receptor-binding domain of the SARS-CoV-2 spike protein and show induction of neutralizing antibodies after intramuscular prime-boost immunization in mice.
Externí odkaz:
https://doaj.org/article/c047e4469bfc4df49317bf7ddb5a7a95
Autor:
Nina Dieu Nhien Tran Nguyen, Safia Guleed, Anja Weinreich Olsen, Frank Follmann, Jan Pravsgaard Christensen, Jes Dietrich
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The requirement for vaccine-induced tissue-resident immunity for protection against one or repeated infections with Chlamydia trachomatis (C.t.) is still not fully resolved. In this study, our aim was to investigate to which degree tissue-resident Th
Externí odkaz:
https://doaj.org/article/078292d308f347e59800f891f7af4924
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Expression of programmed cell death-1 receptor (PD-1) has traditionally been linked to T-cell exhaustion, as signaling via PD-1 dampens the functionality of T-cells upon repetitive antigen exposures during chronic infections. However, resent findings
Externí odkaz:
https://doaj.org/article/75d0925f51da454cbb3d2cad29033de9
Autor:
Anette Stryhn, Michael Kongsgaard, Michael Rasmussen, Mikkel Nors Harndahl, Thomas Østerbye, Maria Rosaria Bassi, Søren Thybo, Mette Gabriel, Morten Bagge Hansen, Morten Nielsen, Jan Pravsgaard Christensen, Allan Randrup Thomsen, Soren Buus
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Examining CD8+ and CD4+ T cell responses after primary Yellow Fever vaccination in a cohort of 210 volunteers, we have identified and tetramer-validated 92 CD8+ and 50 CD4+ T cell epitopes, many inducing strong and prevalent (i.e., immunodominant) T
Externí odkaz:
https://doaj.org/article/b8fb5297c13149d797fdd9685dc406b6
Autor:
Loulieta Nazerai, Amalie Skak Schøller, Maria Rosaria Bassi, Søren Buus, Anette Stryhn, Jan Pravsgaard Christensen, Allan Randrup Thomsen
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Zika virus (ZIKV), a mosquito-borne flavivirus, came into the spotlight in 2016 when it was found to be associated with an increased rate of microcephalic newborns in Brazil. The virus has further been recognized to cause neurologic complications in
Externí odkaz:
https://doaj.org/article/25037e12d8884f6987145d3fded7907e
Autor:
Line Barington, Liv von Voss Christensen, Kristian Kåber Pedersen, Kristine Niss Arfelt, Martin Roumain, Kristian Høj Reveles Jensen, Viktoria Madeline Skovgaard Kjær, Viktorija Daugvilaite, John F. Kearney, Jan Pravsgaard Christensen, Gertrud Malene Hjortø, Giulio G. Muccioli, Peter Johannes Holst, Mette Marie Rosenkilde
Publikováno v:
Cells, Vol 11, Iss 3, p 494 (2022)
B1 cells constitute a specialized subset of B cells, best characterized in mice, which is abundant in body cavities, including the peritoneal cavity. Through natural and antigen-induced antibody production, B1 cells participate in the early defense a
Externí odkaz:
https://doaj.org/article/ecdf797f65d7414b8242f2c44e167d78
Autor:
Terkild Brink Buus, Andreas Willerslev-Olsen, Simon Fredholm, Edda Blümel, Claudia Nastasi, Maria Gluud, Tengpeng Hu, Lise M. Lindahl, Lars Iversen, Hanne Fogh, Robert Gniadecki, Ivan V. Litvinov, Jenny L. Persson, Charlotte Menné Bonefeld, Carsten Geisler, Jan Pravsgaard Christensen, Thorbjørn Krejsgaard, Thomas Litman, Anders Woetmann, Niels Ødum
Publikováno v:
Blood Advances, Vol 2, Iss 16, Pp 2115-2126 (2018)
Abstract: Sézary syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphoma (CTCL) with a median life expectancy of less than 4 years. Although initial treatment responses are often good, the vast majority of patients with SS fail
Externí odkaz:
https://doaj.org/article/b5af0c4ccff540ba900bbbaf4eed2d20