Refining the Design of Diblock Elastin-Like Polypeptides for Self-Assembly into Nanoparticles

Autor: Michèle Dai, Evangelos Georgilis, Guillaume Goudounet, Bertrand Garbay, Jan Pille, Jan C. M. van Hest, Xavier Schultze, Elisabeth Garanger, Sébastien Lecommandoux

Publikováno v: Polymers, Vol 13, Iss 9, p 1470 (2021)

Diblock copolymers based-on elastin-like polypeptide (ELP) have the potential to undergo specific phase transitions when thermally stimulated. This ability is especially suitable to form carriers, micellar structures for instance, for delivering acti

Externí odkaz: https://doaj.org/article/ad3c922aad63411aa62f926208381b3d

Pathway-Dependent Co-Assembly of Elastin-Like Polypeptides

Autor: Nathalie van de Laar, Kirsten Kevenaar, Maarten Merkx, Antonio Aloi, Duc H. T. Le, Jan C. M. van Hest, Jan Pille, Ilia Vialshin, Ilja K. Voets

Publikováno v: Small : Nano Micro, 17(13):2007234. Wiley-VCH Verlag

In natural systems, temperature-induced assembly of biomolecules can lead to the formation of distinct assembly states, created out of the same set of starting compounds, based on the heating trajectory followed. Until now it has been difficult to ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d53bab720bf6013d983d2d137fd61a
https://pubmed.ncbi.nlm.nih.gov/33690936

Nanoparticles based on natural, engineered or synthetic proteins and polypeptides for drug delivery applications

Autor: Elisabeth Garanger, Jan C. M. van Hest, Evangelos Georgilis, Jan Pille, Sébastien Lecommandoux, Esra Aydinlioglu, Mona Abdelghani

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, 2020, 586, pp.119537. ⟨10.1016/j.ijpharm.2020.119537⟩
International Journal of Pharmaceutics, 586:119537. Elsevier
INTERNATIONAL JOURNAL OF PHARMACEUTICS
International Journal of Pharmaceutics, Elsevier, 2020, 586, pp.119537. ⟨10.1016/j.ijpharm.2020.119537⟩

International audience; Medicine formulations at the nanoscale, referred to as nanomedicines, have managed to overcome key challenges encountered during the development of new medical treatments and entered clinical practice, but considerable improve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50abe9a701c1f64030b84785f4a63f7
https://pubmed.ncbi.nlm.nih.gov/32531450

Self-Assembling VHH-Elastin-Like Peptides for Photodynamic Nanomedicine

Autor: William P.J. Leenders, Sanne A. M. van Lith, Jan C. M. van Hest, Jan Pille

Publikováno v: Biomacromolecules
Biomacromolecules, 18, 1302-1310
Biomacromolecules, 18, 4, pp. 1302-1310
Biomacromolecules, 18(4):4, 1302-1310. American Chemical Society

Contains fulltext : 174837.pdf (Publisher’s version ) (Open Access) Recombinant llama heavy-chain antibody fragments (VHHs) are promising tools in the field of targeted nanomedicine. 7D12, a VHH against the epidermal growth factor receptor (EGFR) t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f04cde048a7543e264b5a3ecb3197c
https://pubmed.ncbi.nlm.nih.gov/28269985

Towards the reconstitution of a two-enzyme cascade for resveratrol synthesis on potyvirus particles

Autor: Matti Wahlsten, Thierry Michon, Kristiina Mäkinen, Daniela Cardinale, Jan Pille, Jocelyne Walter, Jane Besong-Ndika

Publikováno v: Frontiers in Plant Science, Vol 7 (2016)
Frontiers in Plant Science
Frontiers in Plant Science, Frontiers, 2016, 7, pp.89. ⟨10.3389/fpls.2016.00089⟩
Frontiers in Plant Science (7), 89. (2016)

International audience; The highly ordered protein backbone of virus particles makes them attractive candidates for use as enzyme nano-carriers (ENCs). We have previously developed a non-covalent and versatile approach for adhesion of enzymes to viru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac68ef1a8f3550f8f6f0ffebec18cb26
http://journal.frontiersin.org/Journal/10.3389/fpls.2016.00089/full