Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jan Pascal Kahler"'
Clotrimazole-Based Modulators of the TRPM3 Ion Channel Reveal Narrow Structure–Activity Relationship
Autor:
Jan Pascal Kahler, Vincenzo Davide Aloi, Julia Miedes Aliaga, Sara Kerselaers, Thomas Voets, Joris Vriens, Steven H. L. Verhelst, Marta Barniol-Xicota
Publikováno v:
ACS Chemical Biology. 18:456-464
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa2809a2dd8550a243c5aa9c28d67397
https://doi.org/10.1021/acschembio.2c00672
https://doi.org/10.1021/acschembio.2c00672
Autor:
Nyamdelger Sukhbaatar, Maria Schöller, Stephanie Deborah Fritsch, Monika Linke, Stefanie Horer, Manuela Träger, Mario Mazic, Stephan Forisch, Karine Gonzales, Jan Pascal Kahler, Carina Binder, Caroline Lassnig, Birgit Strobl, Mathias Mueller, Barbara Scheiber-Mojdehkar, Claudia Gundacker, Stefanie Dabsch, Renate Kain, Markus Hengstschläger, Steven Verhelst, Günter Weiss, Igor Theurl, Thomas Weichhart
Publikováno v:
Blood.
Iron is an essential cellular metal that is important for many physiological functions including erythropoiesis and host defense. It is absorbed from the diet in the duodenum and loaded onto transferrin (Tf), the main iron transport protein. Ineffici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd659f629867c70a85d8d9e7fcef6517
https://doi.org/10.1182/blood.2022016632
https://doi.org/10.1182/blood.2022016632
Autor:
Jian Yang, Dimitris Korovesis, Shanping Ji, Jan Pascal Kahler, Roeland Vanhoutte, Steven H. L. Verhelst
Publikováno v:
Israel Journal of Chemistry. 63
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6195b85acb13c7a9add41082a36d094
https://doi.org/10.1002/ijch.202200094
https://doi.org/10.1002/ijch.202200094
Publikováno v:
RSC Chemical Biology
Activity-based protein profiling enables the specific detection of the active fraction of an enzyme and is of particular use for the profiling of proteases. The technique relies on a mechanism-based reaction between small molecule activity-based prob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41a5bd3f07934bfd9e5a6ecd532a50d
https://pubmed.ncbi.nlm.nih.gov/34458842
https://pubmed.ncbi.nlm.nih.gov/34458842
Publikováno v:
ACS Med Chem Lett
[Image: see text] Serine proteases comprise about one-third of all proteases, and defective regulation of serine proteases is involved in numerous diseases. Therefore, serine protease inhibitors are promising drug candidates. Aminomethyl diphenyl pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df772efb02bb1928c64643671c0b6c69
https://hdl.handle.net/1887/3201317
https://hdl.handle.net/1887/3201317
Publikováno v:
Archivum Immunologiae et Therapiae Experimentalis. 68
Multiple types of immune cells utilize serine proteases in their mechanisms of defense against pathogens or altered host cells. Dysregulation of the serine protease activity from these cells underlies different diseases. In the past, the technique of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e259ee57fab9fda2b95438940032161e
https://doi.org/10.1007/s00005-020-00586-2
https://doi.org/10.1007/s00005-020-00586-2
Autor:
Chris Van den Haute, Sarah van Veen, Johannes V. Swinnen, Roeland Vanhoutte, Jean-Paul Decuypere, Jeffrey Zielich, Joseph A. Lyons, Bart Ghesquière, Géraldine Gelders, Veronick Benoy, Eric J. Lambie, Wim Annaert, Shaun Martin, Veerle Baekelandt, Peter Vangheluwe, Patrizia Agostinis, Jan Eggermont, Jan Pascal Kahler, Steven H. L. Verhelst
ATP13A2 (PARK9) is a late endolysosomal transporter that is genetically implicated in a spectrum of neurodegenerative disorders, including Kufor-Rakeb syndrome—a parkinsonism with dementia1—and early-onset Parkinson’s disease2. ATP13A2 offers p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b02281bb2e77f9e2f4beaaa1f265428
https://lirias.kuleuven.be/handle/123456789/649573
https://lirias.kuleuven.be/handle/123456789/649573
Publikováno v:
ChemBioChem. 19:907-911
Polyamines are essential for cell growth and differentiation, but their trafficking by the polyamine transport system is not fully understood. Herein, the synthesis of several azido-derivatized polyamines for easy conjugation by click chemistry is de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5cff761d4aa0851881e43e58c1cdfef
https://doi.org/10.1002/cbic.201800043
https://doi.org/10.1002/cbic.201800043
Autor:
Suravi, Chakrabarty, Jan Pascal, Kahler, Merel A T, van de Plassche, Roeland, Vanhoutte, Steven H L, Verhelst
Publikováno v:
Current topics in microbiology and immunology. 420
The activity of proteases is tightly regulated, and dysregulation is linked to a variety of human diseases. For this reason, ABPP is a well-suited method to study protease biology and the design of protease probes has pushed the boundaries of ABPP. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c04d804fd5c5fa6c6a60132114a7e4db
https://pubmed.ncbi.nlm.nih.gov/30244324
https://pubmed.ncbi.nlm.nih.gov/30244324
Autor:
Merel A T van de Plassche, Jan Pascal Kahler, Roeland Vanhoutte, Suravi Chakrabarty, Steven H. L. Verhelst
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783030111427
The activity of proteases is tightly regulated, and dysregulation is linked to a variety of human diseases. For this reason, ABPP is a well-suited method to study protease biology and the design of protease probes has pushed the boundaries of ABPP. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c675c476eac90bc752a0f92877623472
https://doi.org/10.1007/82_2018_138
https://doi.org/10.1007/82_2018_138