Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jan Parolek"'
Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
Autor:
Tolulope Sokoya, Jan Parolek, Mads Møller Foged, Dmytro I Danylchuk, Manuel Bozan, Bingshati Sarkar, Angelika Hilderink, Michael Philippi, Lorenzo D Botto, Paulien A Terhal, Outi Mäkitie, Jacob Piehler, Yeongho Kim, Christopher G Burd, Andrey S Klymchenko, Kenji Maeda, Joost CM Holthuis
Publikováno v:
eLife, Vol 11 (2022)
Sphingomyelin is a dominant sphingolipid in mammalian cells. Its production in the trans-Golgi traps cholesterol synthesized in the ER to promote formation of a sphingomyelin/sterol gradient along the secretory pathway. This gradient marks a fundamen
Externí odkaz:
https://doaj.org/article/420811a13b754b8b97db2aafb7c04c32
Autor:
Jan Parolek, Tolulope Sokoya, Mads Møller Foged, Dmytro I Danylchuk, Manuel Bozan, Bingshati Sarkar, Angelika Hilderink, Michael Philippi, Lorenzo D Botto, Paulien A Terhal, Outi Mäkitie, Jacob Piehler, Yeongho Kim, Christopher G Burd, Andrey S Klymchenko, Kenji Maeda, Joost CM Holthuis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3b8f5b0c08c7aceceaf696cda617c3
https://doi.org/10.7554/elife.79278.sa2
https://doi.org/10.7554/elife.79278.sa2
Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
Autor:
Jan Parolek, Tolulope Sokoya, Mads Møller Foged, Dmytro I Danylchuk, Manuel Bozan, Bingshati Sarkar, Angelika Hilderink, Michael Philippi, Lorenzo D Botto, Paulien A Terhal, Outi Mäkitie, Jacob Piehler, Yeongho Kim, Christopher G Burd, Andrey S Klymchenko, Kenji Maeda, Joost CM Holthuis
Publikováno v:
eLife. 11
Sphingomyelin is a dominant sphingolipid in mammalian cells. Its production in the trans-Golgi traps cholesterol synthesized in the ER to promote formation of a sphingomyelin/sterol gradient along the secretory pathway. This gradient marks a fundamen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d47d2e813e9c6831e27915084a83f15
https://pubmed.ncbi.nlm.nih.gov/36102623
https://pubmed.ncbi.nlm.nih.gov/36102623
Autor:
Vladimir Subr, Tomáš Knedlík, Pavel Šácha, Karel Ulbrich, Václav Navrátil, Frantisek Sedlak, Jan Tykvart, Jiří Schimer, Jan Konvalinka, Jiří Strohalm, Pavel Majer, Petra Dvořáková, Jan Parolek
Publikováno v:
Angewandte Chemie (International Ed. in English)
Antibodies are indispensable tools for biomedicine and anticancer therapy. Nevertheless, their use is compromised by high production costs, limited stability, and difficulty of chemical modification. The design and preparation of synthetic polymer co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078ba7fa74f7f313eab7f5615f94b964
https://doi.org/10.1002/anie.201508642
https://doi.org/10.1002/anie.201508642