Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jan Papies"'
Autor:
Jackson Emanuel, Jan Papies, Celine Galander, Julia M. Adler, Nicolas Heinemann, Kathrin Eschke, Sophie Merz, Hannah Pischon, Ruben Rose, Andi Krumbholz, Žarko Kulić, Martin D. Lehner, Jakob Trimpert, Marcel A. Müller
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The occurrence of immune-evasive SARS-CoV-2 strains emphasizes the importance to search for broad-acting antiviral compounds. Our previous in vitro study showed that Pelargonium sidoides DC. root extract EPs® 7630 has combined antiviral and immunomo
Externí odkaz:
https://doaj.org/article/044307d14f644aaf80e4e9beb57d435d
Autor:
Daniela Niemeyer, Saskia Stenzel, Talitha Veith, Simon Schroeder, Kirstin Friedmann, Friderike Weege, Jakob Trimpert, Julian Heinze, Anja Richter, Jenny Jansen, Jackson Emanuel, Julia Kazmierski, Fabian Pott, Lara M Jeworowski, Ruth Olmer, Mark-Christian Jaboreck, Beate Tenner, Jan Papies, Felix Walper, Marie L Schmidt, Nicolas Heinemann, Elisabeth Möncke-Buchner, Morris Baumgardt, Karen Hoffmann, Marek Widera, Tran Thi Nhu Thao, Anita Balázs, Jessica Schulze, Christin Mache, Terry C Jones, Markus Morkel, Sandra Ciesek, Leif G Hanitsch, Marcus A Mall, Andreas C Hocke, Volker Thiel, Klaus Osterrieder, Thorsten Wolff, Ulrich Martin, Victor M Corman, Marcel A Müller, Christine Goffinet, Christian Drosten
Publikováno v:
PLoS Biology, Vol 20, Iss 11, p e3001871 (2022)
Epidemiological data demonstrate that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) Alpha and Delta are more transmissible, infectious, and pathogenic than previous variants. Phenotypic properties of VOC rema
Externí odkaz:
https://doaj.org/article/f439c20a5aa647faba500c0b3fd9f88a
Autor:
Nils C. Gassen, Jan Papies, Thomas Bajaj, Jackson Emanuel, Frederik Dethloff, Robert Lorenz Chua, Jakob Trimpert, Nicolas Heinemann, Christine Niemeyer, Friderike Weege, Katja Hönzke, Tom Aschman, Daniel E. Heinz, Katja Weckmann, Tim Ebert, Andreas Zellner, Martina Lennarz, Emanuel Wyler, Simon Schroeder, Anja Richter, Daniela Niemeyer, Karen Hoffmann, Thomas F. Meyer, Frank L. Heppner, Victor M. Corman, Markus Landthaler, Andreas C. Hocke, Markus Morkel, Nikolaus Osterrieder, Christian Conrad, Roland Eils, Helena Radbruch, Patrick Giavalisco, Christian Drosten, Marcel A. Müller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Viruses manipulate host cell pathways to support infection. Here the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.
Externí odkaz:
https://doaj.org/article/a210cbf8766241fd8d824076b3b287b5
Autor:
Jan Papies, Andrea Sieberg, Daniel Ritz, Daniela Niemeyer, Christian Drosten, Marcel A. Müller
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Eidolon helvum bats are reservoir hosts for highly pathogenic lyssaviruses often showing limited disease upon natural infection. An enhanced antiviral interferon (IFN) response combined with reduced inflammation might be linked to the apparent virus
Externí odkaz:
https://doaj.org/article/db0822e8d58542aebe659b74f584d2ef
Autor:
Nils C. Gassen, Daniela Niemeyer, Doreen Muth, Victor M. Corman, Silvia Martinelli, Alwine Gassen, Kathrin Hafner, Jan Papies, Kirstin Mösbauer, Andreas Zellner, Anthony S. Zannas, Alexander Herrmann, Florian Holsboer, Ruth Brack-Werner, Michael Boshart, Bertram Müller-Myhsok, Christian Drosten, Marcel A. Müller, Theo Rein
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Here, Gassen et al. show that S-phase kinase-associated protein 2 (SKP2) is responsible for lysine-48-linked poly-ubiquitination of beclin 1, resulting in its proteasomal degradation, and that inhibition of SKP2 enhances autophagy and reduces replica
Externí odkaz:
https://doaj.org/article/173953915c6a47688637a8c938baf515
Autor:
Jan Papies, Jackson Emanuel, Nicolas Heinemann, Žarko Kulić, Simon Schroeder, Beate Tenner, Martin D. Lehner, Georg Seifert, Marcel A. Müller
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/ba6232004d3f456f984fd86bfa12be59
Autor:
Jan Papies, Jackson Emanuel, Nicolas Heinemann, Žarko Kulić, Simon Schroeder, Beate Tenner, Martin D. Lehner, Georg Seifert, Marcel A. Müller
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Treatment options for COVID-19 are currently limited. Drugs reducing both viral loads and SARS-CoV-2-induced inflammatory responses would be ideal candidates for COVID-19 therapeutics. Previous in vitro and clinical studies suggest that the proprieta
Externí odkaz:
https://doaj.org/article/9631bde06b974129a613201d9045a8ac
Autor:
Emanuel Wyler, Kirstin Mösbauer, Vedran Franke, Asija Diag, Lina Theresa Gottula, Roberto Arsiè, Filippos Klironomos, David Koppstein, Katja Hönzke, Salah Ayoub, Christopher Buccitelli, Karen Hoffmann, Anja Richter, Ivano Legnini, Andranik Ivanov, Tommaso Mari, Simone Del Giudice, Jan Papies, Samantha Praktiknjo, Thomas F. Meyer, Marcel Alexander Müller, Daniela Niemeyer, Andreas Hocke, Matthias Selbach, Altuna Akalin, Nikolaus Rajewsky, Christian Drosten, Markus Landthaler
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102151- (2021)
Summary: Detailed knowledge of the molecular biology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is crucial for understanding of viral replication, host responses, and disease progression. Here, we report gene expression
Externí odkaz:
https://doaj.org/article/aa494f159d1e4728b02c9632c197db4f
Autor:
Nadine Krüger, Christian Sauder, Sarah Hüttl, Jan Papies, Kathleen Voigt, Georg Herrler, Kornelia Hardes, Torsten Steinmetzer, Claes Örvell, Jan Felix Drexler, Christian Drosten, Steven Rubin, Marcel Alexander Müller, Markus Hoffmann
Publikováno v:
Cell Reports, Vol 25, Iss 2, Pp 312-320.e7 (2018)
Summary: Bats harbor a plethora of viruses with an unknown zoonotic potential. In-depth functional characterization of such viruses is often hampered by a lack of virus isolates. The genome of a virus closely related to human mumps viruses (hMuV) was
Externí odkaz:
https://doaj.org/article/e114a6f9dfa840e3b71cb8a008c52bf6
Autor:
Daniela Niemeyer, Saskia Stenzel, Talitha Veith, Simon Schroeder, Kirstin Friedmann, Friderike Weege, Jakob Trimpert, Julian Heinze, Anja Richter, Jenny Jansen, Jackson Emanuel, Julia Kazmierski, Fabian Pott, Lara M. Jeworowski, Ruth Olmer, Mark-Christian Jaboreck, Beate Tenner, Jan Papies, Felix Walper, Marie L. Schmidt, Nicolas Heinemann, Elisabeth Möncke-Buchner, Morris Baumgardt, Karen Hoffmann, Marek Widera, Tran Thi Nhu Thao, Anita Balázs, Jessica Schulze, Christin Mache, Terry C. Jones, Markus Morkel, Sandra Ciesek, Leif G. Hanitsch, Marcus A. Mall, Andreas C. Hocke, Volker Thiel, Klaus Osterrieder, Thorsten Wolff, Ulrich Martin, Victor M. Corman, Marcel A. Müller, Christine Goffinet, Christian Drosten
Publikováno v:
Niemeyer, Daniela; Stenzel, Saskia; Veith, Talitha; Schroeder, Simon; Friedmann, Kirstin; Weege, Friderike; Trimpert, Jakob; Heinze, Julian; Richter, Anja; Jansen, Jenny; Emanuel, Jackson; Kazmierski, Julia; Pott, Fabian; Jeworowski, Lara M.; Olmer, Ruth; Jaboreck, Mark-Christian; Tenner, Beate; Papies, Jan; Walper, Felix; Schmidt, Marie L.; ... (2022). SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression. PLoS biology, 20(11), e3001871. Public Library of Science 10.1371/journal.pbio.3001871
Epidemiological data demonstrate that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) Alpha and Delta are more transmissible, infectious, and pathogenic than previous variants. Phenotypic properties of VOC rema