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Autor:
Jan P. G. Brakenhoff, Lou F. M. H. de Leij, Mireille G. F. Gerrits, Rokus A. de Zeeuw, Johan Wemer, W.J Tamminga, Jan H.G. Jonkman, B. Oosterhuis
Publikováno v:
European Journal of Clinical Pharmacology. 57:143-146
A method for simultaneous phenotyping and genotyping for CYP2D6 and CYP2C19 was tested. Six healthy volunteers were selected (three extensive and three poor metabolisers for CYP2D6). CYP2D6 was probed with dextromethorphan and metoprolol and CYP2C19