Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jan P Tuckermann"'
Autor:
Alessa Wagner, Betül Alan, Dilay Yilmaz, Mubashir Ahmad, Peng Liu, Naveen Kumar Tangudu, Jan P Tuckermann, Maja Vujic Spasic
Publikováno v:
JBMR Plus, Vol 3, Iss 9, Pp n/a-n/a (2019)
ABSTRACT One of the most prevalent genetic iron overload disorders in Caucasians is caused by mutations in the HFE gene. Both HFE patients and Hfe‐mouse models develop a progressive accumulation of iron in the parenchymal cells of various tissues,
Externí odkaz:
https://doaj.org/article/ef5d4c51fa1a49018d7c42e45649da0c
Autor:
Christine Müller, Laura M Zidek, Tobias Ackermann, Tristan de Jong, Peng Liu, Verena Kliche, Mohamad Amr Zaini, Gertrud Kortman, Liesbeth Harkema, Dineke S Verbeek, Jan P Tuckermann, Julia von Maltzahn, Alain de Bruin, Victor Guryev, Zhao-Qi Wang, Cornelis F Calkhoven
Publikováno v:
eLife, Vol 7 (2018)
Ageing is associated with physical decline and the development of age-related diseases such as metabolic disorders and cancer. Few conditions are known that attenuate the adverse effects of ageing, including calorie restriction (CR) and reduced signa
Externí odkaz:
https://doaj.org/article/b7abb0080c274a6897de4c882258f497
Autor:
Simone Wüst, Denise Tischner, Michael John, Jan P Tuckermann, Christiane Menzfeld, Uwe-Karsten Hanisch, Jens van den Brandt, Fred Lühder, Holger M Reichardt
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8202 (2009)
BACKGROUND: Dissociating glucocorticoid receptor (GR) ligands hold great promise for treating inflammatory disorders since it is assumed that they exert beneficial activities mediated by transrepression but avoid adverse effects of GR action requirin
Externí odkaz:
https://doaj.org/article/9131bf4fc0fc475bbecdc5ffc8b0ca31
Autor:
Aishwarya Iyer-Bierhoff, Martin Wieczorek, Sina Marielle Peter, Dima Ward, Martin Bens, Sabine Vettorazzi, Karl-Heinz Guehrs, Jan P. Tuckermann, Thorsten Heinzel
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108943- (2024)
Summary: Glucocorticoid (GC) signaling is essential for mounting a stress response, however, chronic stress or prolonged GC therapy downregulates the GC receptor (GR), leading to GC resistance. Regulatory mechanisms that refine this equilibrium are n
Externí odkaz:
https://doaj.org/article/cf90c7c5d2ad4e608db75592fcbbf55b
Autor:
Giorgio Caratti, Ulrich Stifel, Bozhena Caratti, Ali J. M. Jamil, Kyoung-Jin Chung, Michael Kiehntopf, Markus H. Gräler, Matthias Blüher, Alexander Rauch, Jan P. Tuckermann
Insulin resistance (IR) during obesity is linked to adipose tissue macrophage (ATM)-driven inflammation of adipose tissue. Whether anti-inflammatory glucocorticoids (GCs) at physiological levels modulate IR is unclear. Here, we report that deletion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d7784762cc7cc8313fd7a53c2da958
Autor:
Giorgio Caratti, Thibaut Desgeorges, Gaëtan Juban, Ulrich Stifel, Aurélie Fessard, Mascha Koenen, Bozhena Caratti, Marine Théret, Carsten Skurk, Bénédicte Chazaud, Jan P Tuckermann, Rémi Mounier
Macrophages are key cells after tissue damage since they mediate both acute inflammatory phase and regenerative inflammation by shifting from pro-inflammatory to restorative cells. Glucocorticoids (GCs) are the most potent anti-inflammatory hormone i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe217c6af0dbf216f31decfdc796710
Increased osteoclastogenesis contributes to bone loss in the Costello syndrome Hras G12V mouse model
Autor:
Sayantan Nandi, Saravanakkumar Chennappan, Yannik Andrasch, Miray Fidan, Melanie Engler, Mubashir Ahmad, Jan P. Tuckermann, Martin Zenker, Ion Cristian Cirstea
Publikováno v:
Frontiers in Cell and Developmental Biology. 10
RAS GTPases are ubiquitous GDP/GTP-binding proteins that function as molecular switches in cellular signalling and control numerous signalling pathways and biological processes. Pathogenic mutations in RAS genes severely affect cellular homeostasis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4900a3a9589e5038bae04c1e996c47
Autor:
Martin, Wepler, Jonathan M, Preuss, Cornelia, Tilp, Martina, Keck, Jochen, Blender, Ulrich, Wachter, Tamara, Merz, Josef, Vogt, Sandra, Kress, Michael, Gröger, Andrea, Hoffmann, Marina, Fink, Enrico, Calzia, Ute, Burret, Peter, Radermacher, Jan P, Tuckermann, Sabine, Vettorazzi
Publikováno v:
Frontiers in Immunology. 13
IntroductionWe previously showed that attenuated glucocorticoid receptor (GR) function in mice (GRdim/dim) aggravates systemic hypotension and impairs organ function during endotoxic shock. Hemorrhagic shock (HS) causes impaired organ perfusion, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f252ec0e1d7469d58f1e5709a4b1b09
https://doi.org/10.3389/fimmu.2022.980707
https://doi.org/10.3389/fimmu.2022.980707
Autor:
Bozhena Caratti, Miray Fidan, Giorgio Caratti, Kristina Breitenecker, Melanie Engler, Naser Kazemitash, Rebecca Traut, Rainer Wittig, Emilio Casanova, Mohammad Reza Ahmadian, Jan P. Tuckermann, Herwig P. Moll, Ion Cristian Cirstea
Publikováno v:
Science signaling. 15(726)
Mutations that activate members of the RAS family of GTPases are associated with various cancers and drive tumor growth. The glucocorticoid receptor (GR), a member of the nuclear receptor family, has been proposed to interact with and inhibit the act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5c3387d7bd6fb6e038bd47deb7cbac
https://pubmed.ncbi.nlm.nih.gov/35316097
https://pubmed.ncbi.nlm.nih.gov/35316097
Autor:
Jonathan M. Preuss, Ute Burret, Michael Gröger, Sandra Kress, Angelika Scheuerle, Peter Möller, Jan P. Tuckermann, Martin Wepler, Sabine Vettorazzi
Publikováno v:
Cells; Volume 11; Issue 1; Pages: 112
Cells
Cells, Vol 11, Iss 112, p 112 (2022)
Cells
Cells, Vol 11, Iss 112, p 112 (2022)
We previously showed that attenuated lung injury after hemorrhagic shock (HS) coincided with enhanced levels of the glucocorticoid (GC) receptor (GR) in lung tissue of swine. Here, we investigated the effects of impaired GR signaling on the lung duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4135b3e1cc6845257a822e33d1dddd02