Risk factors for development of hemolytic uremic syndrome in a cohort of adult patients with STEC 0104:H4 infection.

Autor: Alexander Zoufaly, Jakob P Cramer, Eik Vettorazzi, Friedhelm Sayk, Jan P Bremer, Irmtraut Koop, Andreas de Weerth, Stefan Schmiedel, Sabine Jordan, Katharina Fraedrich, Niels H Asselborn, Martin Nitschke, Christine Neumann-Grutzeck, Tim Magnus, Christoph Rüther, Klaus Fellermann, Rolf K Stahl, Karl Wegscheider, Ansgar W Lohse

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e59209 (2013)

The outbreak of Shiga toxin producing E.coli O104:H4 in northern Germany in 2011 was one of the largest worldwide and involved mainly adults. Post-diarrheal hemolytic uremic syndrome (HUS) occurred in 22% of STEC positive patients. This study's aim w

Externí odkaz: https://doaj.org/article/7f0badab694b49cc93e9b550cd3775b9

Characteristics and outcomes of SARS-CoV-2 breakthrough infections among double-vaccinated and triple-vaccinated patients with inflammatory rheumatic diseases

Autor: Tobias Alexander, Hendrik Schulze-Koops, Ulf Müller-Ladner, Rebecca Fischer-Betz, Martin Aringer, Rieke Alten, Petra Saar, Tim Schmeiser, Marina Backhaus, Stephanie Finzel, Cornelia Glaser, Hildrun Haibel, Hanns-Martin Lorenz, Gamal Chehab, Christof Specker, Reinhard E Voll, Anja Strangfeld, Norbert Blank, Matthias Braun, Alexander Pfeil, Rebecca Hasseli, Andreas Krause, Anne Constanze Regierer, Peer Aries, Ioana Andreica, Jacqueline Detert, Elvira Decker, Urs Hartmann, Joerg Henes, Kirsten de Groot, JOACHIM GEORGI, Hans Bastian, Christoph Fiehn, Martin Feuchtenberger, Martin Fleck, Christian Blum, Mathias Grunke, Martin Bohl-Bühler, Georg Gauler, Bimba Franziska Hoyer, Guido Hoese, Janine Günther, Matthias Braunisch, Jutta G. Richter, Sabine Reckert, Anett Gräßler, Andreas Kapelle, Silke Osiek, Anna Knothe, Jan Brandt-Jürgens, Anja Maltzahn, Fredrik Albach, Annette Alberding, Susanne Aman, Christopher Amberger, Michaela Amberger, Bianka Andermann, Nils Anders, Jan Andresen, Nikolaos Andriopoulos, Elizabeth Arauj, Uta Arndt, Sarah Avemarg, Christoph Baerwald, Erich Bärlin, Nora Bartholomä, Michael Bäuerle, Jutta Bauhammer, Christine Baumann, Klaus Becker, Heidemarie Becker, Michaela Bellm, Sylvia Berger, Andrea Berghofen, Gerhard Birkner, Daniel Blendea, Hans Bloching, Sebastian Blötz, Stephanie Boeddeker, Susanne Bogner, Lara Bohnen, Ilka Bösenberg, Nicole Böttcher, Diana Braun, Jan Philipp Bremer, Matthias Broll, Andreas Bruckner, Veronika Brumberger, Martin Brzank, Sahra Büllesfeld, Sandra Burger, Michaela Christenn, Anne Claußnitzer, Frank Demtröder, Rainer Dörfler, Elke Drexler, Valeria Dudics, Edmund Edelmann, Roman Eder, Christina Eisterhues, Joachim Michael Engel, Brigitte Erbslöh-Möller, Miriam Feine, Samantha Ferdinan, Claudia Franke, Stefanie Freudenberg, Christian Fräbel, Petra Fuchs, Regina Gaissmaier, Ino Gao, Oliver Gardt, Katrin Geißler, Karolina Gente, Jasmin Gilly, Yannik Gkanatsas, Agnes Gniezinski- Schwister, Rahel Gold, Norman Görl, Ralf Görlitz, Karl-Heinz Göttl, Beate Göttle, Ricardo Grieshaber Bouyer, Gisela Grothues, Florian Günther, Mirjam Haag, Linda Haas, Anna Haas-Wöhrle, Denitsa Hadjiski, Till Hallmann-Böhm, Peter Härle, Charlotte Hasenkamp, Maura-Maria Hauf, Matthias Hauser

Publikováno v: RMD Open, Vol 9, Iss 2 (2023)

Objective To analyse the clinical profile of SARS-CoV-2 breakthrough infections in at least double-vaccinated patients with inflammatory rheumatic diseases (IRDs).Methods Data from the physician-reported German COVID-19-IRD registry collected between

Externí odkaz: https://doaj.org/article/bcd65462c49f49369021f75255aee09c

GOAT: Deep learning-enhanced Generalized Organoid Annotation Tool

Autor: Jan P. Bremer, Martin E. Baumdick, Marius S. Knorr, Lucy H.M. Wegner, Jasmin Wesche, Ana Jordan-Paiz, Johannes M. Jung, Andrew J. Highton, Julia Jäger, Ole Hinrichs, Sebastien Brias, Jennifer Niersch, Luisa Müller, Renée R.C.E. Schreurs, Tobias Koyro, Sebastian Löbl, Leonore Mensching, Leonie Konczalla, Annika Niehrs, Florian W. R. Vondran, Christoph Schramm, Angelique Hölzemer, Karl Oldhafer, Ingo Königs, Stefan Kluge, Daniel Perez, Konrad Reinshagen, Steven T. Pals, Nicola Gagliani, Sander P. Joosten, Maya Topf, Marcus Altfeld, Madeleine J. Bunders

Organoids have emerged as a powerful technology to investigate human development, model diseases and for drug discovery. However, analysis tools to rapidly and reproducibly quantify organoid parameters from microscopy images are lacking. We developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13521250821e90d01118ad2f34ec3450
https://doi.org/10.1101/2022.09.06.506648

Manifestation der eosinophilen Granulomatose mit Polyangiitis im Kopf-Hals-Bereich im zeitlichen Verlauf unter Berücksichtigung der systemischen Krankheitsaktivität

Autor: Henrik Andersen, Paul Götz, Martin Laudien, Jan P Bremer

Publikováno v: Zeitschrift für Rheumatologie. 77:928-937

Die eosinophile Granulomatose mit Polyangiitis (EGPA) ist eine seltene granulomatose Vaskulitis der kleinen und mittelgrosen Blutgefase unbekannter Atiologie. Eine regelmasige Beteiligung im Kopf-Hals-Bereich ist beschrieben. Da bislang nicht bekannt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::049ab46c56aa651a14e5cee6d864497e
https://doi.org/10.1007/s00393-018-0439-0

Cyclophosphamide treatment-induced leukopenia rates in ANCA-associated vasculitis are influenced by variant CYP450 2C9 genotypes

Autor: Julia U Holle, Jan H. Schirmer, Peter Lamprecht, Ingolf Cascorbi, Sierk Haenisch, Jan P Bremer, Stefan Wieczorek, Frank Moosig

Publikováno v: Pharmacogenomics. 17(4)

Aim: Correlation of outcomes of cyclophosphamide (CP) therapy in antineutrophil cytoplasmic antibody-associated vasculitis with genotype polymorphisms in prodrug activating cytochrome P450 enzyme genes CYP2C9 and CYP2C19. Patients & methods: One hund

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b57cd459e6af65532dc5f3075061a7
https://pubmed.ncbi.nlm.nih.gov/26894931