Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jan P, Bogen"'
Autor:
Julia Harwardt, Stefania C. Carrara, Jan P. Bogen, Katrin Schoenfeld, Julius Grzeschik, Björn Hock, Harald Kolmar
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
To construct a trispecific IgG-like antibody at least three different binding moieties need to be combined, which results in a complex architecture and challenging production of these molecules. Here we report for the first time the construction of t
Externí odkaz:
https://doaj.org/article/9fb531027f17410a9441b28858737aba
Autor:
David Fiebig, Jan P. Bogen, Stefania C. Carrara, Lukas Deweid, Stefan Zielonka, Julius Grzeschik, Björn Hock, Harald Kolmar
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Yeast-surface display (YSD) is commonly applied to screen Fab immune or naïve libraries for binders of predefined target molecules. However, reformatting of isolated variants represents a time-intensive bottleneck. Herein, we present a novel approac
Externí odkaz:
https://doaj.org/article/07962c2c56b2491d9d889fe9fed966c1
Autor:
Julia Harwardt, Jan P. Bogen, Stefania C. Carrara, Michael Ulitzka, Julius Grzeschik, Björn Hock, Harald Kolmar
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Various formats of bispecific antibodies exist, among them Two-in-One antibodies in which each Fab arm can bind to two different antigens. Their IgG-like architecture accounts for low immunogenicity and also circumvents laborious engineering and puri
Externí odkaz:
https://doaj.org/article/baa198aa1ffd4bf4a0f536479913b5c4
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15673 (2022)
The Tyro, Axl, and MerTK receptors (TAMRs) play a significant role in the clearance of apoptotic cells. In this work, the spotlight was set on MerTK, as it is one of the prominent TAMRs expressed on the surface of macrophages and dendritic cells. Mer
Externí odkaz:
https://doaj.org/article/045d8cc7924947b78f757b87dbeb0075
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Natural killer cell engagers gained enormous interest in recent years due to their potent anti-tumor activity and favorable safety profile. Simultaneously, chicken-derived antibodies entered clinical studies paving the way for avian-derived therapeut
Externí odkaz:
https://doaj.org/article/a90d47a64eea4424ba866d67b3ea3e30
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Bladder cancer is a frequent malignancy and has a clinical need for new therapeutic approaches. Antibody and protein technologies came a long way in recent years and new engineering approaches were applied to generate innovative therapeutic entities
Externí odkaz:
https://doaj.org/article/2baf03aa60ca4d78ac97ae835d7c5f92
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Bispecific (BsAb) and biparatopic (BpAb) antibodies emerged as promising formats for therapeutic biologics exhibiting tailor-made functional properties. Over recent years, chicken-derived antibodies have gained traction for diagnostic and therapeutic
Externí odkaz:
https://doaj.org/article/3f3672396f1b46d3abe7207446757a2f
Publikováno v:
Antibodies, Vol 10, Iss 2, p 18 (2021)
Monoclonal antibodies (mAbs) have demonstrated tremendous effects on the treatment of various disease indications and remain the fastest growing class of therapeutics. Production of recombinant antibodies is performed using mammalian expression syste
Externí odkaz:
https://doaj.org/article/618caab871564ae9a80491b80eafe118
Autor:
Jan P. Bogen, Steffen C. Hinz, Julius Grzeschik, Aileen Ebenig, Simon Krah, Stefan Zielonka, Harald Kolmar
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Shedding of membrane-bound cell surface proteins, where the extracellular domain is released and found in the circulation is a common phenomenon. A prominent example is CEACAM5 (CEA, CD66e), where the shed domain plays a pivotal role in tumor progres
Externí odkaz:
https://doaj.org/article/ba9e1d5ff49340b0a93de1a3cf3e2c24
Publikováno v:
Biospektrum
Due to the large evolutionary distance between birds (Aves) und humans, immunization of chickens with human proteins results in a strong response of the bird’s adaptive immune system to proteins of mammalian origin. Additionally, chicken-derived an