Výsledky vyhledávání - "Jan O. Kemnade"

Akademický článek

Deployment of cisplatin in Veterans with oropharyngeal cancer: toxicity and impact on oncologic outcomes

Autor: Ola Soliman, David C. Wilde, Jan O. Kemnade, Anita L. Sabichi, George Chen, Albert Chen, Samantha N. Little, Andrew T. Huang, David J. Hernandez, Vlad C. Sandulache

Publikováno v: Laryngoscope Investigative Otolaryngology, Vol 8, Iss 4, Pp 895-902 (2023)

Abstract Objective Cisplatin forms the backbone of systemic chemotherapy treatment for oropharyngeal squamous cell carcinoma (OPSCC). The ideal cisplatin dosing regimen remains yet to be fully defined for achieving optimal efficacy and toxicity profi

Externí odkaz: https://doaj.org/article/63e9ba405d214ea08428bffef1d69cc1

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Akademický článek

Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects

Autor: Ratna Veeramachaneni, Wangjie Yu, Jared M Newton, Jan O Kemnade, Heath D Skinner, Andrew G Sikora, Vlad C Sandulache

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)

Background Metformin is a commonly used antidiabetic medication which has demonstrated promise as an anticancer agent alone and in combination with conventional treatment regimens. There is increasing evidence that metformin can also generate immunom

Externí odkaz: https://doaj.org/article/fa7f5b93207b47babfaf128e1c021790

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Persistent Ethnicity-Associated Disparity in Antitumor Effectiveness of Immune Checkpoint Inhibitors Despite Equal Access

Autor: Marcus A. Florez, Jan O. Kemnade, Nan Chen, Wendy Du, Anita L. Sabichi, Daniel Y. Wang, Quillan Huang, Courtney N. Miller-Chism, Aparna Jotwani, Albert C. Chen, David Hernandez, Vlad C. Sandulache

Publikováno v: Cancer Res Commun

We reviewed response to immune checkpoint inhibitors (ICI) of 207 patients with diagnoses of lung or head and neck cancer treated with chemotherapy/ICI combination therapy and ICI monotherapy between 2015 and 2020 at one of three clinical pavilions a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029ba1f46bf4925c45898e45209901d6
https://doi.org/10.1158/2767-9764.crc-21-0143

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Oropharyngeal cancer outcomes correlate with p16 status, multinucleation and immune infiltration

Publikováno v: Modern Pathology. 35:1045-1054

Oropharyngeal squamous cell carcinoma (OPSCC), largely fueled by the human papillomavirus (HPV), has a complex biological and immunologic phenotype. Although HPV/p16 status can be used to stratify OPSCC patients as a function of survival, it remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4401eec1d6b9d4ad8d812ad9c7670aca
https://doi.org/10.1038/s41379-022-01024-8

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Supplementary Data from Persistent Ethnicity-Associated Disparity in Antitumor Effectiveness of Immune Checkpoint Inhibitors Despite Equal Access

Autor: Vlad C. Sandulache, David Hernandez, Albert C. Chen, Aparna Jotwani, Courtney N. Miller-Chism, Quillan Huang, Daniel Y. Wang, Anita L. Sabichi, Wendy Du, Nan Chen, Jan O. Kemnade, Marcus A. Florez

Combined supplementary data file.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9692a7ab17ef13e17bec4885e267b9
https://doi.org/10.1158/2767-9764.22545324.v1

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Data from Persistent Ethnicity-Associated Disparity in Antitumor Effectiveness of Immune Checkpoint Inhibitors Despite Equal Access

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6c6c928ac0b7b8e0fb9c1aa441e78e
https://doi.org/10.1158/2767-9764.c.6550908

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Human epidermal growth factor receptor 2 expression in head and neck squamous cell carcinoma: Variation within and across primary tumor sites, and implications for antigen‐specific immunotherapy

Autor: Meenakshi Hegde, Patricia Castro, Wendong Yu, Vlad C. Sandulache, Andrew G. Sikora, Joshua Anil, Jan O. Kemnade, Masataka Suzuki, John Hicks, Emilie A K Warren

Publikováno v: Head Neck

Background The purpose of this study is to describe human epidermal growth factor 2 (HER2) overexpression in head and neck squamous cell carcinoma (HNSCC) and re-evaluate its potential as a target for HER2-directed immunotherapies. Methods A retrospe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc21715917085771a8973cc9b0127f06
https://doi.org/10.1002/hed.26662

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Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects

Autor: Jared M. Newton, Jan O. Kemnade, Andrew G. Sikora, Ratna Veeramachaneni, Heath D. Skinner, Wangjie Yu, Vlad C. Sandulache

Publikováno v: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)

BackgroundMetformin is a commonly used antidiabetic medication which has demonstrated promise as an anticancer agent alone and in combination with conventional treatment regimens. There is increasing evidence that metformin can also generate immunomo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb162a33927d8ffde484d4c096c59b54
http://europepmc.org/articles/PMC8261884

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