Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Jan O Korbel"'
Autor:
Büşra Erarslan‐Uysal, Joachim B Kunz, Tobias Rausch, Paulina Richter‐Pechańska, Ianthe AEM vanBelzen, Viktoras Frismantas, Beat Bornhauser, Diana Ordoñez‐Rueada, Malte Paulsen, Vladimir Benes, Martin Stanulla, Martin Schrappe, Gunnar Cario, Gabriele Escherich, Kseniya Bakharevich, Renate Kirschner‐Schwabe, Cornelia Eckert, Tsvetomir Loukanov, Matthias Gorenflo, Sebastian M Waszak, Jean‐Pierre Bourquin, Martina U Muckenthaler, Jan O Korbel, Andreas E Kulozik
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 9, Pp n/a-n/a (2020)
Abstract We aimed at identifying the developmental stage at which leukemic cells of pediatric T‐ALLs are arrested and at defining leukemogenic mechanisms based on ATAC‐Seq. Chromatin accessibility maps of seven developmental stages of human healt
Externí odkaz:
https://doaj.org/article/22d6864d026e473bab1f5a0e5f21e0cf
Autor:
Fruzsina Molnár‐Gábor, Jan O Korbel
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp n/a-n/a (2020)
Genomic data sharing is becoming more important as scientists join forces across borders in biomedical research for the benefit of patients and society. The EU's General Data Protection Regulation (GDPR) helps simplify sharing of such data at the Eur
Externí odkaz:
https://doaj.org/article/8248c49d5b1840229a8ab70e793bd77f
Autor:
Lorena Salgueiro, Christopher Buccitelli, Konstantina Rowald, Kalman Somogyi, Sridhar Kandala, Jan O Korbel, Rocio Sotillo
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp n/a-n/a (2020)
Abstract Chromosome instability (CIN) has been associated with therapeutic resistance in many cancers. However, whether tumours become genomically unstable as an evolutionary mechanism to overcome the bottleneck exerted by therapy is not clear. Using
Externí odkaz:
https://doaj.org/article/225029ac68f7435d9344bd21f7538671
Autor:
Jan Haas, Stefan Mester, Alan Lai, Karen S Frese, Farbod Sedaghat‐Hamedani, Elham Kayvanpour, Tobias Rausch, Rouven Nietsch, Jes‐Niels Boeckel, Avisha Carstensen, Mirko Völkers, Carsten Dietrich, Dietmar Pils, Ali Amr, Daniel B Holzer, Diana Martins Bordalo, Daniel Oehler, Tanja Weis, Derliz Mereles, Sebastian Buss, Eva Riechert, Emil Wirsz, Maximilian Wuerstle, Jan O Korbel, Andreas Keller, Hugo A Katus, Andreas E Posch, Benjamin Meder
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 107-120 (2018)
Abstract The transcriptome needs to be tightly regulated by mechanisms that include transcription factors, enhancers, and repressors as well as non‐coding RNAs. Besides this dynamic regulation, a large part of phenotypic variability of eukaryotes i
Externí odkaz:
https://doaj.org/article/4481e23c5007408586f68c9d973d8b8f
Autor:
Paulina Richter‐Pechańska, Joachim B Kunz, Beat Bornhauser, Caroline vonKnebel Doeberitz, Tobias Rausch, Büşra Erarslan‐Uysal, Yassen Assenov, Viktoras Frismantas, Blerim Marovca, Sebastian M Waszak, Martin Zimmermann, Julia Seemann, Margit Happich, Martin Stanulla, Martin Schrappe, Gunnar Cario, Gabriele Escherich, Kseniya Bakharevich, Renate Kirschner‐Schwabe, Cornelia Eckert, Martina U Muckenthaler, Jan O Korbel, Jean‐Pierre Bourquin, Andreas E Kulozik
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 12, Pp n/a-n/a (2018)
Abstract We compared 24 primary pediatric T‐cell acute lymphoblastic leukemias (T‐ALL) collected at the time of initial diagnosis and relapse from 12 patients and 24 matched patient‐derived xenografts (PDXs). DNA methylation profile was preserv
Externí odkaz:
https://doaj.org/article/a41b214baa0c4e7083befa1edbc53289
Autor:
Chip Stewart, Deniz Kural, Michael P Strömberg, Jerilyn A Walker, Miriam K Konkel, Adrian M Stütz, Alexander E Urban, Fabian Grubert, Hugo Y K Lam, Wan-Ping Lee, Michele Busby, Amit R Indap, Erik Garrison, Chad Huff, Jinchuan Xing, Michael P Snyder, Lynn B Jorde, Mark A Batzer, Jan O Korbel, Gabor T Marth, Genomes Project
Publikováno v:
PLoS Genetics, Vol 7, Iss 8, p e1002236 (2011)
As a consequence of the accumulation of insertion events over evolutionary time, mobile elements now comprise nearly half of the human genome. The Alu, L1, and SVA mobile element families are still duplicating, generating variation between individual
Externí odkaz:
https://doaj.org/article/bb06859b1fcd42df8b29c66de975a2c7
Autor:
Sebastian M Waszak, Yehudit Hasin, Thomas Zichner, Tsviya Olender, Ifat Keydar, Miriam Khen, Adrian M Stütz, Andreas Schlattl, Doron Lancet, Jan O Korbel
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 11, p e1000988 (2010)
Copy-number variations (CNVs) are widespread in the human genome, but comprehensive assignments of integer locus copy-numbers (i.e., copy-number genotypes) that, for example, enable discrimination of homozygous from heterozygous CNVs, have remained c
Externí odkaz:
https://doaj.org/article/55e67763b13046bab013d5e4fd461399
Autor:
K T Nishant, Wu Wei, Eugenio Mancera, Juan Lucas Argueso, Andreas Schlattl, Nicolas Delhomme, Xin Ma, Carlos D Bustamante, Jan O Korbel, Zhenglong Gu, Lars M Steinmetz, Eric Alani
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001109 (2010)
Accurate estimates of mutation rates provide critical information to analyze genome evolution and organism fitness. We used whole-genome DNA sequencing, pulse-field gel electrophoresis, and comparative genome hybridization to determine mutation rates
Externí odkaz:
https://doaj.org/article/c65c8961fd824d25a5aad85f13b20ace
High-resolution copy-number variation map reflects human olfactory receptor diversity and evolution.
Autor:
Yehudit Hasin, Tsviya Olender, Miriam Khen, Claudia Gonzaga-Jauregui, Philip M Kim, Alexander Eckehart Urban, Michael Snyder, Mark B Gerstein, Doron Lancet, Jan O Korbel
Publikováno v:
PLoS Genetics, Vol 4, Iss 11, p e1000249 (2008)
Olfactory receptors (ORs), which are involved in odorant recognition, form the largest mammalian protein superfamily. The genomic content of OR genes is considerably reduced in humans, as reflected by the relatively small repertoire size and the high
Externí odkaz:
https://doaj.org/article/b3358faa764a47c091d1d7646c3985e8
Autor:
Jan O Korbel, Tobias Doerks, Lars J Jensen, Carolina Perez-Iratxeta, Szymon Kaczanowski, Sean D Hooper, Miguel A Andrade, Peer Bork
Publikováno v:
PLoS Biology, Vol 3, Iss 5, p e134 (2005)
One of the major challenges of functional genomics is to unravel the connection between genotype and phenotype. So far no global analysis has attempted to explore those connections in the light of the large phenotypic variability seen in nature. Here
Externí odkaz:
https://doaj.org/article/dbc1889e4f1445f3b5c2e376ad3ef480