Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jan Naujoks"'
Autor:
Christoph Tabeling, Carla R. González Calera, Jasmin Lienau, Jakob Höppner, Thomas Tschernig, Olivia Kershaw, Birgitt Gutbier, Jan Naujoks, Julia Herbert, Bastian Opitz, Achim D. Gruber, Berthold Hocher, Norbert Suttorp, Harald Heidecke, Gerd-R. Burmester, Gabriela Riemekasten, Elise Siegert, Wolfgang M. Kuebler, Martin Witzenrath
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionInflammation is a major pathological feature of pulmonary arterial hypertension (PAH), particularly in the context of inflammatory conditions such as systemic sclerosis (SSc). The endothelin system and anti-endothelin A receptor (ETA) aut
Externí odkaz:
https://doaj.org/article/5155352f8be8490f9215fb4954370d03
Autor:
Juan S Ruiz-Moreno, Lutz Hamann, Javeed A Shah, Annelies Verbon, Frank P Mockenhaupt, Monika Puzianowska-Kuznicka, Jan Naujoks, Leif E Sander, Martin Witzenrath, John C Cambier, Norbert Suttorp, Ralf R Schumann, Lei Jin, Thomas R Hawn, Bastian Opitz, CAPNETZ Study Group
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006829 (2018)
The cyclic GMP-AMP synthase (cGAS)-STING pathway is central for innate immune sensing of various bacterial, viral and protozoal infections. Recent studies identified the common HAQ and R232H alleles of TMEM173/STING, but the functional consequences o
Externí odkaz:
https://doaj.org/article/d3654b56d2484ffba732894f1bf15756
Autor:
Kristina Dietert, Birgitt Gutbier, Sandra M Wienhold, Katrin Reppe, Xiaohui Jiang, Ling Yao, Catherine Chaput, Jan Naujoks, Markus Brack, Alexandra Kupke, Christin Peteranderl, Stephan Becker, Carolin von Lachner, Nelli Baal, Hortense Slevogt, Andreas C Hocke, Martin Witzenrath, Bastian Opitz, Susanne Herold, Holger Hackstein, Leif E Sander, Norbert Suttorp, Achim D Gruber
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188251 (2017)
Pneumonia may be caused by a wide range of pathogens and is considered the most common infectious cause of death in humans. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease
Externí odkaz:
https://doaj.org/article/e118d1a225d845ef9ec169aa82829540
Autor:
Jan Naujoks, Christoph Tabeling, Brian D Dill, Christine Hoffmann, Andrew S Brown, Mareike Kunze, Stefan Kempa, Andrea Peter, Hans-Joachim Mollenkopf, Anca Dorhoi, Olivia Kershaw, Achim D Gruber, Leif E Sander, Martin Witzenrath, Susanne Herold, Andreas Nerlich, Andreas C Hocke, Ian van Driel, Norbert Suttorp, Sammy Bedoui, Hubert Hilbi, Matthias Trost, Bastian Opitz
Publikováno v:
PLoS Pathogens, Vol 12, Iss 2, p e1005408 (2016)
Macrophages can be niches for bacterial pathogens or antibacterial effector cells depending on the pathogen and signals from the immune system. Here we show that type I and II IFNs are master regulators of gene expression during Legionella pneumophil
Externí odkaz:
https://doaj.org/article/eaa236391a7d4f88ad687cf6bf355f63
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39908 (2012)
Several pathogenic bacteria utilize receptors of the CEACAM family to attach to human cells. Binding to different members of this receptor family can result in uptake of the bacteria. Uptake of Neisseria gonorrhoeae, a gram-negative human pathogen, v
Externí odkaz:
https://doaj.org/article/75c08097b4f1478eb1887e41e7a8bcc1
Autor:
Mareike Berlak, Zuzanna Makowska, Filippos Klironomos, Julia Kuehnlenz, Atanas Kamburov, Andreas Steffen, Martin Lange, Barbara Nicke, Ralf Lesche, Peter Staller, Charlotte Kopitz, Jan Naujoks
Publikováno v:
Cancer Research. 83:6089-6089
The Hippo signaling cascade is a major pathway that integrates a broad spectrum of mechanosensory signals at the plasma membrane and regulates response via control of cell proliferation, self-renewal, differentiation, and apoptosis. Dysregulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d97e88c3074aa7701ef4af05c2e60d1b
https://doi.org/10.1158/1538-7445.am2023-6089
https://doi.org/10.1158/1538-7445.am2023-6089
Publikováno v:
International Journal of Medical Microbiology. 308:161-167
Legionella pneumophila is a facultative intracellular bacterium which can cause a severe pneumonia called Legionnaires' disease after inhalation of contaminated water droplets and replication in alveolar macrophages. The innate immune system is gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c6700f7f5fa010804ef6ab2ed34b3f
https://doi.org/10.1016/j.ijmm.2017.10.004
https://doi.org/10.1016/j.ijmm.2017.10.004
Autor:
Lisette Potze, Ekaterina Nevedomskaya, Benjamin Bader, Julia Kuehnlenz, Claudia Luther, Peter Staller, Jan Naujoks, Andreas Steffen, Atanas Kamburov, Anna Anurin, Anne Buttgereit, Ralf Lesche, Barbara Nicke, Stefan Prechtl, Martin Lange
Publikováno v:
Molecular Cancer Research. 18:A29-A29
Aberrant activation of the Hippo pathway effectors YAP1/TAZ promotes cell proliferation and tumorigenesis. To identify novel regulators of YAP1/TAZ in cancer, we established a FACS-based screening system monitoring YAP1/TAZ activity in MDA-MB-231 bre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bd4f7d906a8f01a33b0b5497553b99e
https://doi.org/10.1158/1557-3125.hippo19-a29
https://doi.org/10.1158/1557-3125.hippo19-a29
Autor:
Elena Noe, Christoph Tabeling, Robert Klopfleisch, Martin Witzenrath, Bastian Opitz, Jan Naujoks, JM Doehn, Stefan Hippenstiel
Publikováno v:
Annals of Anatomy - Anatomischer Anzeiger. 196:365-371
Megaesophagus in mice has been associated with several genetic defects. In the present study we expand the range of genes associated with esophageal function and morphology by protein kinase C alpha (PKCα). PKCα-deficient mice showed a six times in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd63be320cbf89bf2a66abf21662554a
https://doi.org/10.1016/j.aanat.2014.04.001
https://doi.org/10.1016/j.aanat.2014.04.001
Autor:
Martin Lange, Jan Naujoks, Ekaterina Nevedomskaya, Anna Anurin, Julia Kuehnlenz, Ralf Lesche, Atanas Kamburov, Andreas Steffen, Lisette Potze, Barbara Nicke
Publikováno v:
Cancer Research. 79:3055-3055
Aberrant activation of the Hippo pathway effectors YAP1/TAZ promotes cell proliferation and tumorigenesis. To identify novel regulators of YAP1/TAZ as a possible means to treat cancer, we established a novel, FACS-based screening system monitoring YA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9218007bf9eb8d3e3d02c14e33403473
https://doi.org/10.1158/1538-7445.am2019-3055
https://doi.org/10.1158/1538-7445.am2019-3055