Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Jan N. M. Commandeur"'
Autor:
Yongjie Zhang, Shalenie P. den Braver-Sewradj, Michiel W. den Braver, Steven Hiemstra, Nico P. E. Vermeulen, Bob van de Water, Jan N. M. Commandeur, J. C. Vos
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Formation of the reactive amodiaquine quinoneimine (AQ-QI) and N-desethylamodiaquine quinoneimine (DEAQ-QI) plays an important role in the toxicity of the anti-malaria drug amodiaquine (AQ). Glutathione conjugation protects against AQ-induced toxicit
Externí odkaz:
https://doaj.org/article/8167ea147acd4c4f8d185eef0cbbc4ab
Autor:
Karla Frydenvang, Marlies C A Verkade-Vreeker, Floor Dohmen, Jan N M Commandeur, Maria Rafiq, Osman Mirza, Flemming Steen Jørgensen, Daan P Geerke
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217292 (2019)
The bacterial Cytochrome P450 (CYP) BM3 (CYP102A1) is one of the most active CYP isoforms. BM3 mutants can serve as a model for human drug-metabolizing CYPs and/or as biocatalyst for selective formation of drug metabolites. Hence, molecular and compu
Externí odkaz:
https://doaj.org/article/4ca0b68792244c2ca63e3d37d9ec192e
Autor:
Liliana Capinha, Yaran Zhang, Anna-Katharina Holzer, Anna-Katharina Ückert, Melinda Zana, Giada Carta, Cormac Murphy, Jenna Baldovini, Zahra Mazidi, Johannes Grillari, Andras Dinnyes, Bob van de Water, Marcel Leist, Jan N. M. Commandeur, Paul Jennings
Publikováno v:
Archives of Toxicology
Archives of Toxicology, 97(2), 523-545. Springer Verlag
Archives of Toxicology, 97, 523-545
Capinha, L, Zhang, Y, Holzer, A K, Ückert, A K, Zana, M, Carta, G, Murphy, C, Baldovini, J, Mazidi, Z, Grillari, J, Dinnyes, A, van de Water, B, Leist, M, Commandeur, J N M & Jennings, P 2023, ' Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models ', Archives of Toxicology, vol. 97, no. 2, pp. 523-545 . https://doi.org/10.1007/s00204-022-03436-6
Archives of Toxicology, 97(2), 523-545. Springer Verlag
Archives of Toxicology, 97, 523-545
Capinha, L, Zhang, Y, Holzer, A K, Ückert, A K, Zana, M, Carta, G, Murphy, C, Baldovini, J, Mazidi, Z, Grillari, J, Dinnyes, A, van de Water, B, Leist, M, Commandeur, J N M & Jennings, P 2023, ' Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models ', Archives of Toxicology, vol. 97, no. 2, pp. 523-545 . https://doi.org/10.1007/s00204-022-03436-6
Environmental or occupational exposure of humans to trichloroethylene (TCE) has been associated with different extrahepatic toxic effects, including nephrotoxicity and neurotoxicity. Bioactivation of TCE via the glutathione (GSH) conjugation pathway
Autor:
Alexander Speer, Kerstin Wallraven, Sandra Ortega Ugalde, Tom N. Grossmann, Jan N. M. Commandeur, Wilbert Bitter
Publikováno v:
Ortega Ugalde, S, Wallraven, K, Speer, A, Bitter, W, Grossmann, T N & Commandeur, J N M 2020, ' Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis ', Biochemical Pharmacology, vol. 177, 113938, pp. 113938 . https://doi.org/10.1016/j.bcp.2020.113938
Biochemical Pharmacology, 177:113938, 1-14. Elsevier Inc.
Biochemical Pharmacology, 177:113938. Elsevier Inc.
Ortega Ugalde, S, Wallraven, K, Speer, A, Bitter, W, Grossmann, T N & Commandeur, J N M 2020, ' Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis ', Biochemical Pharmacology, vol. 177, 113938, pp. 1-14 . https://doi.org/10.1016/j.bcp.2020.113938
Biochemical Pharmacology, 177:113938, 1-14. Elsevier Inc.
Biochemical Pharmacology, 177:113938. Elsevier Inc.
Ortega Ugalde, S, Wallraven, K, Speer, A, Bitter, W, Grossmann, T N & Commandeur, J N M 2020, ' Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis ', Biochemical Pharmacology, vol. 177, 113938, pp. 1-14 . https://doi.org/10.1016/j.bcp.2020.113938
Tuberculosis (TB) is a globally significant infective disease that is caused by a single infectious agent, Mycobacterium tuberculosis (Mtb). Because of the rise in the number of multidrug-resistant (MDR) TB strains, identification of alternative drug
Publikováno v:
ChemBioChem, 21(10), 1461-1472. Wiley-VCH Verlag
Chembiochem
Luirink, R A, Verkade-Vreeker, M C A, Commandeur, J N M & Geerke, D P 2020, ' A Modified Arrhenius Approach to Thermodynamically Study Regioselectivity in Cytochrome P450-Catalyzed Substrate Conversion ', ChemBioChem, vol. 21, no. 10, pp. 1461-1472 . https://doi.org/10.1002/cbic.201900751
Chembiochem
Luirink, R A, Verkade-Vreeker, M C A, Commandeur, J N M & Geerke, D P 2020, ' A Modified Arrhenius Approach to Thermodynamically Study Regioselectivity in Cytochrome P450-Catalyzed Substrate Conversion ', ChemBioChem, vol. 21, no. 10, pp. 1461-1472 . https://doi.org/10.1002/cbic.201900751
The regio‐ (and stereo‐)selectivity and specific activity of cytochrome P450s are determined by the accessibility of potential sites of metabolism (SOMs) of the bound substrate relative to the heme, and the activation barrier of the regioselectiv
Autor:
Luigi Capoferri, Marlies C A Verkade-Vreeker, Danny Buitenhuis, Jan N M Commandeur, Manuel Pastor, Nico P E Vermeulen, Daan P Geerke
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142232 (2015)
Prediction of human Cytochrome P450 (CYP) binding affinities of small ligands, i.e., substrates and inhibitors, represents an important task for predicting drug-drug interactions. A quantitative assessment of the ligand binding affinity towards diffe
Externí odkaz:
https://doaj.org/article/3ed89fa3fa634a258200e17253a8f53b
Publikováno v:
Capinha, L, Jennings, P & Commandeur, J N M 2021, ' Bioactivation of trichloroethylene to three regioisomeric glutathione conjugates by liver fractions and recombinant human glutathione transferases : Species differences and implications for human risk assessment ', Toxicology Letters, vol. 341, pp. 94-106 . https://doi.org/10.1016/j.toxlet.2021.01.021
Toxicology Letters
Toxicology Letters, 341, 94-106. Elsevier BV
Toxicology Letters
Toxicology Letters, 341, 94-106. Elsevier BV
Enzymatic conjugation of glutathione (GSH) to trichloroethylene (TCE) followed by catabolism to the corresponding cysteine-conjugate, S-(dichlorovinyl)-L-cysteine (DCVC), and subsequent bioactivation by renal cysteine conjugate beta-lyases is conside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45175c8d7a05afaee62c2c21e1e14b06
https://research.vu.nl/en/publications/a98072a0-c624-48db-97b9-c6740b5fb2a8
https://research.vu.nl/en/publications/a98072a0-c624-48db-97b9-c6740b5fb2a8
Publikováno v:
Ortega Ugalde, S, Ma, D, Cali, J J & Commandeur, J N M 2019, ' Evaluation of Luminogenic Substrates as Probe Substrates for Bacterial Cytochrome P450 Enzymes : Application to Mycobacterium tuberculosis ', SLAS Discovery, vol. 24, no. 7, pp. 745-754 . https://doi.org/10.1177/2472555219853220, https://doi.org/10.1177/2472555219853220
SLAS Discovery, 24(7), 745-754. SAGE Publications Inc.
SLAS Discovery, 24(7), 745-754. SAGE Publications Inc.
Several cytochrome P450 enzymes (CYPs) encoded in the genome of Mycobacterium tuberculosis (Mtb) are considered potential new drug targets due to the essential roles they play in bacterial viability and in the establishment of chronic intracellular i
Publikováno v:
British Journal of Pharmacology. 176:466-477
Background and purpose The aim of this study was to characterize the human cytochrome P450s (CYPs) involved in oxidative bioactivation of flucloxacillin to 5-hydroxymethyl flucloxacillin, a metabolite with high cytotoxicity towards biliary epithelial
Publikováno v:
Capinha, L, Jennings, P & Commandeur, J N M 2021, ' Corrigendum to “Bioactivation of trichloroethylene to three regioisomeric glutathione conjugates by liver fractions and recombinant human glutathione transferases: Species differences and implications for human risk assessment” [Toxicol. Lett. 341 (2021) 94–106] ', Toxicology Letters, vol. 343, pp. 67-68 . https://doi.org/10.1016/j.toxlet.2021.02.011
The authors regret that in Fig. 1 the letters indicating the enzymes involved in the reactions were not added to the arrows. A corrected Figure is shown below. [Figure presented] Fig. 1. Regioselective GSH-conjugation of trichloroethylene (TCE) and s