Zobrazeno 1 - 10
of 251
pro vyhledávání: '"Jan Michiels"'
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 102984- (2024)
Summary: Bacterial persisters constitute a small fraction of cells that transiently display multidrug tolerance, allowing them to survive antibiotic treatment and to establish a new population upon recovery from the persistent state. Here, we present
Externí odkaz:
https://doaj.org/article/04519dd1bfee493f8be1ef508d5e941c
Autor:
Liselot Dewachter, Aaron N. Brooks, Katherine Noon, Charlotte Cialek, Alia Clark-ElSayed, Thomas Schalck, Nandini Krishnamurthy, Wim Versées, Wim Vranken, Jan Michiels
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Deep mutational scanning can be used to investigate protein function and stability. Here, Dewachter et al. use deep mutational scanning on three essential bacterial proteins to study the mutations’ effects in their original genomic context, providi
Externí odkaz:
https://doaj.org/article/32c3951dd8e34dadbbb42bed12452929
Autor:
Laure Verstraete, Juliana Aizawa, Matthias Govaerts, Linda De Vooght, Rob Lavigne, Jan Michiels, Bram Van den Bergh, Paul Cos
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Clinicians are increasingly confronted with the limitations of antibiotics to clear bacterial infections in patients. It has long been assumed that only antibiotic resistance plays a pivotal role in this phenomenon. Indeed, the worldwide eme
Externí odkaz:
https://doaj.org/article/83282c08b8d9451ea879b04eab7619b7
Autor:
Bram Van den Bergh, Hannah Schramke, Joran Elie Michiels, Tom E. P. Kimkes, Jakub Leszek Radzikowski, Johannes Schimpf, Silke R. Vedelaar, Sabrina Burschel, Liselot Dewachter, Nikola Lončar, Alexander Schmidt, Tim Meijer, Maarten Fauvart, Thorsten Friedrich, Jan Michiels, Matthias Heinemann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Antibiotic persisters are phenotypic variants within an isogenic bacterial population that are transiently tolerant to antibiotic treatment. Here, the authors provide evidence that cytoplasmic acidification, amplified by a compromised respiratory com
Externí odkaz:
https://doaj.org/article/0e4b4b380cf34e90a750b02dfc2a0648
Autor:
Katleen Vandamme, Karin Thevissen, Marcelo F. Mesquita, Ruxandra‐Gabriella Coropciuc, Jimoh Agbaje, Patrick Thevissen, Wander José da Silva, Jozef Vleugels, Kaat De Cremer, Evelien Gerits, Johan A. Martens, Jan Michiels, Bruno P. A. Cammue, Annabel Braem
Publikováno v:
Clinical and Experimental Dental Research, Vol 7, Iss 4, Pp 502-511 (2021)
Abstract Objectives New strategies for implant surface functionalization in the prevention of peri‐implantitis while not compromising osseointegration are currently explored. The aim of this in vivo study was to assess the osseointegration of a tit
Externí odkaz:
https://doaj.org/article/66f9aa170d6c4c958ad7c91570544fb5
Autor:
Liselot Dewachter, Aaron N. Brooks, Katherine Noon, Charlotte Cialek, Alia Clark-ElSayed, Thomas Schalck, Nandini Krishnamurthy, Wim Versées, Wim Vranken, Jan Michiels
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/ff608562e056407fa9c719bd2a329b2c
Autor:
Karin Voordeckers, Camilla Colding, Lavinia Grasso, Benjamin Pardo, Lore Hoes, Jacek Kominek, Kim Gielens, Kaat Dekoster, Jonathan Gordon, Elisa Van der Zande, Peter Bircham, Toon Swings, Jan Michiels, Peter Van Loo, Sandra Nuyts, Philippe Pasero, Michael Lisby, Kevin J. Verstrepen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Whereas the toxic effects of ethanol are well-documented, the underlying mechanism is obscure. This study uses the eukaryotic model S. cerevisiae to reveal how exposure to sublethal ethanol concentrations causes DNA replication stress and an increase
Externí odkaz:
https://doaj.org/article/df587fed078742dfbc9ad32716f400df
Autor:
Liselot Dewachter, Celien Bollen, Dorien Wilmaerts, Elen Louwagie, Pauline Herpels, Paul Matthay, Ladan Khodaparast, Laleh Khodaparast, Frederic Rousseau, Joost Schymkowitz, Jan Michiels
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Decades of research into bacterial persistence has been unable to fully characterize this antibiotic-tolerant phenotype, thereby hampering the development of therapies effective against chronic infections. Although some active persister mech
Externí odkaz:
https://doaj.org/article/25a864ad0b934f97852bf42dc666e337
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
While protein aggregation is predominantly associated with loss of function and toxicity, it is also known to increase survival of bacteria under stressful conditions. Indeed, protein aggregation not only helps bacteria to cope with proteotoxic stres
Externí odkaz:
https://doaj.org/article/ba1fba54e94944659492839239477024
Autor:
Laetitia Van Wonterghem, Matteo De Chiara, Gianni Liti, Jonas Warringer, Anne Farewell, Natalie Verstraeten, Jan Michiels
Publikováno v:
Microorganisms, Vol 10, Iss 3, p 608 (2022)
The emergence and dissemination of antibiotic resistance threaten the treatment of common bacterial infections. Resistance genes are often encoded on conjugative elements, which can be horizontally transferred to diverse bacteria. In order to delay c
Externí odkaz:
https://doaj.org/article/761ab043a7d048c3872773f70d2b8754