Cerebrospinal Fluid Concentrations of Meropenem and Vancomycin in Ventriculitis Patients Obtained by TDM-Guided Continuous Infusion

Autor: Christoph Tiede, Ute Chiriac, Daniel Dubinski, Florian J. Raimann, Otto R. Frey, Anka C. Röhr, Anna Wieduwilt, Michael Eibach, Natalie Filmann, Christian Senft, Kai Zacharowski, Volker Seifert, Jan Mersmann

Publikováno v: Antibiotics, Vol 10, Iss 11, p 1421 (2021)

Effective antibiotic therapy of cerebral infections such as meningitis or ventriculitis is hindered by low penetration into the cerebrospinal fluid (CSF). Because continuous infusion of meropenem and vancomycin and routine therapeutic drug monitoring

Externí odkaz: https://doaj.org/article/73c1a0fba63e4d55a69f5689187453a4

Intravenous Sphingosylphosphorylcholine Protects Ischemic and Postischemic Myocardial Tissue in a Mouse Model of Myocardial Ischemia/Reperfusion Injury

Autor: Christine Herzog, Martina Schmitz, Bodo Levkau, Ilka Herrgott, Jan Mersmann, Jan Larmann, Kai Johanning, Michael Winterhalter, Jerold Chun, Frank Ulrich Müller, Frank Echtermeyer, Reinhard Hildebrand, Gregor Theilmeier

Publikováno v: Mediators of Inflammation, Vol 2010 (2010)

HDL, through sphingosine-1-phosphate (S1P), exerts direct cardioprotective effects on ischemic myocardium. It remains unclear whether other HDL-associated sphingophospholipids have similar effects. We therefore examined if HDL-associated sphingosylph

Externí odkaz: https://doaj.org/article/9a7fbf5f493a40e6aeb456112e6149f7

Evaluation of a Clinical Decision Support System for the most evidence-based approach to managing perioperative anticoagulation

Autor: Lisa-Marie, Buchner, Eun Ji, Park, Pamela, Bendz, Anne, Englert, Cornelius, von der Groeben, Linda, Vo, Elke, Schmitt, Kai, Zacharowski, Philipp, Börm, Dominik, Stauber, Tobias, Bingold, Michael, Booke, Mathias, Gerth, Clemens-Alexander, Greim, Jan, Mersmann, Ralf Michael, Muellenbach, Haitham, Mutlak, Bernhard, Ott, Andreas, Pape, Michael, Sander, Rolf, Teßmann, Martin, Welte, Julius, Wermelt, Hinnerk, Wulf, Suma, Choorapoikayil, Christoph, Füllenbach, Patrick, Meybohm

Publikováno v: Journal of Clinical Anesthesia. 80:110877

We explored the feasibility of a Clinical Decision Support System (CDSS) to guide evidence-based perioperative anticoagulation.Prospective randomised clinical management simulation multicentre study.Five University and 11 general hospitals in Germany

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9d6d3143ac84870107f21c2be2e9f5
https://doi.org/10.1016/j.jclinane.2022.110877

Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney

Autor: Bertram Scheller, Vera Sprunck, Florian J Raimann, Thorsten J. Maier, Anja Urbschat, Rainer Hofmann, Axel Hegele, Jan Mersmann, Kai Zacharowski, Patrick C. Baer

Publikováno v: Urbschat, A, Baer, P, Zacharowski, K, Sprunck, V, Scheller, B, Raimann, F, Maier, T J, Hegele, A, Hofmann, R & Mersmann, J 2018, ' Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney ', Basic & Clinical Pharmacology & Toxicology, vol. 122, no. 2, pp. 223-232 . https://doi.org/10.1111/bcpt.12896

Acute kidney injury remains an important cause of renal dysfunction. In this context, Toll-like receptors have been demonstrated to play a critical role in the induction of innate and inflammatory responses. Among these, Toll-like receptor 2 (TLR2) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8740b20e0ad1a3d1f08d1bc65ac5ff56
https://doi.org/10.1111/bcpt.12896

An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis

Autor: Madalina V. Nastase, Janet Beckmann, Louise Tzung Harn Hsieh, Jan Mersmann, Josef Pfeilschifter, Chiara Poluzzi, Liliana Schaefer, Renato V. Iozzo, Jaime Lopez-Mosqueda, Fumiyo Ikeda, Jinyang Zeng-Brouwers, Ivan Dikic, Nina Schroeder, Helena Frey

Publikováno v: The American Journal of Pathology. 186:1206-1220

Sepsis is burdened by high mortality due to uncontrolled inflammatory response to pathogens. Increased caspase 1 activation causing maturation of IL1β/18 remains a therapeutic challenge in sepsis. SHARPIN (shank-associated regulator of G-protein sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e8c483b3567b3e7f6ea515c8e88d3f
https://doi.org/10.1016/j.ajpath.2015.12.026