Kinetics of Biomarkers of Oxidative Stress in Septic Shock: A Pilot Study

Autor: Martin Helan, Jan Malaska, Josef Tomandl, Jiri Jarkovsky, Katerina Helanova, Klara Benesova, Michal Sitina, Milan Dastych, Tomas Ondrus, Monika Pavkova Goldbergova, Roman Gal, Petr Lokaj, Marie Tomandlova, Jiri Parenica

Publikováno v: Antioxidants, Vol 11, Iss 4, p 640 (2022)

Septic shock is a major cause of mortality in ICU patients, its pathophysiology is complex and not properly understood. Oxidative stress seems to be one of the most important mechanisms of shock progression to multiple organ failure. In the present p

Externí odkaz: https://doaj.org/article/1423f386f1bd4135b46c9a37a3d82924

Epidemiology of hospital-acquired pneumonia: Results of a Central European multicenter, prospective, observational study compared with data from the European region

Autor: Tomas Herkel, Radovan Uvizl, Lenka Doubravska, Milan Adamus, Tomas Gabrhelik, Miroslava Htoutou Sedlakova, Milan Kolar, Vojtech Hanulik, Vendula Pudova, Katerina Langova, Roman Zazula, Tomas Rezac, Michal Moravec, Pavel Cermak, Pavel Sevcik, Jan Stasek, Jan Malaska, Alena Sevcikova, Marketa Hanslianova, Zdenek Turek, Vladimir Cerny, Pavla Paterova

Publikováno v: Biomedical Papers, Vol 160, Iss 3, Pp 448-455 (2016)

Background: Hospital-acquired pneumonia (HAP) is associated with high mortality. In Central Europe, there is a dearth of information on the prevalence and treatment of HAP. This project was aimed at collecting multicenter epidemiological data on pati

Externí odkaz: https://doaj.org/article/ae2d6345ca9b42eea9f9f8959af1a493

Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts

Autor: David Brealey, Marco Maggiorini, Yannick Malledant, Jan Malaska, Gabriela Droc, Manu Malbrain, Didier Payen, Herbert Spapen, Xavier Wittebole, Marc Leone, Giuseppe Citerio, Angel Estella, Alain LEPAPE, Prof. Katarzyna Laura Kotfis, Pasquale De Negri, Morten Bestle, Artigas Antonio, Ewa Trejnowska, Walter Swinnen, Ricard Ferrer

Publikováno v: Critical Care, 25
Critical care, Vol. 25, no.1, p. 87 [1-12] (2021)
Critical care, 25 (1
Sakr, Yasser; François, Bruno; Solé-Violan, Jordi; Kotfis, Katarzyna; Jaschinski, Ulrich; Estella, Angel; Leone, Marc; Jakob, Stephan M.; Wittebole, Xavier; Fontes, Luis E; de Melo Gurgel, Miguel; Midega, Thais; Vincent, Jean-Louis; Ranieri, V Marco (2021). Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts. Critical care, 25(1), p. 87. BioMed Central 10.1186/s13054-020-03455-8
CRITICAL CARE
Critical Care
Critical Care, Vol 25, Iss 1, Pp 1-12 (2021)
Critical Care, 25, 1
Critical care, vol. 25, pp. 1-12, 2021.
Critical Care, 2021, 25 (1), pp.87. ⟨10.1186/s13054-020-03455-8⟩

BACKGROUND: Mortality rates for patients with ARDS remain high. We assessed temporal changes in the epidemiology and management of ARDS patients requiring invasive mechanical ventilation in European ICUs. We also investigated the association between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a51e5335568ba91e4298228a1c107b

Effect of dexamethasone in patients with ARDS and COVID-19 (REMED trial)—study protocol for a prospective, multi-centre, open-label, parallel-group, randomized controlled trial

Autor: Jan Maláska, Jan Stašek, František Duška, Martin Balík, Jan Máca, Jan Hruda, Tomáš Vymazal, Olga Klementová, Jan Zatloukal, Tomáš Gabrhelík, Pavel Novotný, Regina Demlová, Jana Kubátová, Jana Vinklerová, Adam Svobodník, Milan Kratochvíl, Jozef Klučka, Roman Gál, Mervyn Singer, on behalf of the REMED Study Group

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-15 (2022)

Abstract Background Since December 2019, SARS-CoV-2 virus has infected millions of people worldwide. In patients with COVID-19 pneumonia in need of oxygen therapy or mechanical ventilation, dexamethasone 6 mg per day is currently recommended. However

Externí odkaz: https://doaj.org/article/5c615221586d44d4a16957c8f0faefdc

Update on Therapeutic Drug Monitoring of Beta-Lactam Antibiotics in Critically Ill Patients—A Narrative Review

Autor: Jan Stašek, Filip Keller, Veronika Kočí, Jozef Klučka, Eva Klabusayová, Ondřej Wiewiorka, Zuzana Strašilová, Miroslava Beňovská, Markéta Škardová, Jan Maláska

Publikováno v: Antibiotics, Vol 12, Iss 3, p 568 (2023)

Beta-lactam antibiotics remain one of the most preferred groups of antibiotics in critical care due to their excellent safety profiles and their activity against a wide spectrum of pathogens. The cornerstone of appropriate therapy with beta-lactams i

Externí odkaz: https://doaj.org/article/1751e502d09c4fe38df94ee9c4cc9383