Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Jan M. Woynarowski"'
Publikováno v:
Molecular and Biochemical Parasitology. 154:70-81
Human malaria parasites, including the most lethal Plasmodium falciparum , are increasingly resistant to existing antimalarial drugs. One remarkable opportunity to selectively target P. falciparum stems from the unique AT-richness of its genome (80%
Autor:
Huiyun Liang, Richard A. Salinas, Belinda Z. Leal, Teresa Kosakowska-Cholody, Christopher J. Michejda, Stephen J. Waters, Terence S. Herman, Jan M. Woynarowski, Barbara A. Woynarowska
Publikováno v:
Molecular Cancer Therapeutics. 3:1385-1396
Irofulven (hydroxymethylacylfulvene) is a novel antitumor drug, which acts by alkylating cellular macromolecular targets. The drug is a potent inducer of apoptosis in various types of tumor cells, whereas it is nonapoptotic in normal cells. This stud
Autor:
Alex V. Trevino, Barbara A. Woynarowska, Terence S. Herman, Waldemar Priebe, Jan M. Woynarowski
Publikováno v:
Molecular Cancer Therapeutics. 3:1403-1410
Targeting topoisomerase II (topo II) is regarded as an important component of the pleiotropic mechanism of action of anthracycline drugs. Here, we show that 4-demethoxy analogues of doxorubicin, including annamycin, exhibit a greater ability to trap
Autor:
Stephen J. Waters, John R. MacDonald, Alex V. Trevino, Jan M. Woynarowski, Richard A. Salinas, Terence S. Herman, Barbara A. Woynarowska
Publikováno v:
Cancer Biology & Therapy. 3:1137-1142
Unlike postmitotic cell death, direct premitotic apoptosis diminishes the risk of clonal selection and allows for the elimination of slowly growing cancer cells. This study characterized the ability to induce premitotic apoptosis by irofulven (hydrox
Autor:
Jan M. Woynarowski, Jennifer A. Jackson, Terence S. Herman, Alex V. Trevino, Maryanne C. Herzig
Publikováno v:
Nucleic Acids Research. 31:6354-6364
AT-rich minisatellites (AT islands) are sites of genomic instability in cancer cells and targets for extremely lethal AT-specific drugs, such as bizelesin. Here we investigated the AT islands in the FRA16B fragile site region for their possible roles
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1587:309-317
Elimination of cancer cells by early apoptosis is preferred over other forms of cell growth inhibition. Apoptosis directly leads to tumor regression and reduces risks of selecting more aggressive and/or drug-resistant phenotypes that are often respon
Publikováno v:
Journal of Biological Chemistry. 276:40555-40566
Interstrand cross-links at T(A/T)4A sites in cellular DNA are associated with hypercytotoxicity of an anticancer drug, bizelesin. Here we evaluated whether these lethal effects reflect targeting critical genomic regions. An in silico analysis of huma
Autor:
Eric Raymond, Alex V. Trevino, Alexandra Vaisman, Stephen G. Chaney, Sandrine Faivre, Paul E. Juniewicz, Maryanne C. Herzig, William G. Chapman, Jan M. Woynarowski, Brenda Arnett, Maria Varchenko
Publikováno v:
Molecular Pharmacology. 58:920-927
Damage to cellular DNA is believed to determine the antiproliferative properties of platinum (Pt) drugs. This study characterized DNA damage by oxaliplatin, a diaminocyclohexane Pt drug with clinical antitumor activity. Compared with cisplatin, oxali
Autor:
John R. MacDonald, Jan M. Woynarowski, Barbara A. Woynarowska, Kari Roberts, Terence S. Herman
Publikováno v:
Radiation Research. 154:429-438
Hydroxymethylacylfulvene (HMAF) is a novel agent with alkylating activity and is a potent inducer of apoptosis that is currently undergoing Phase II clinical trials for prostate cancer. This study explored the pro-apoptosis and anti-proliferative pot
Publikováno v:
Biochemistry. 39:9917-9927
Bizelesin and adozelesin are DNA-reactive antitumor drugs that alkylate adenines at the 3' ends of their preferred binding sites [5'T(A/T)(4)A3'and 5'(A/T)(3)(-4)A3', respectively]. We used these drugs to examine the determinants for region-specific