Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jan M. Spink"'
Autor:
Yongzheng Zhang, Stephen M. Manzo, Derek A. Beauchamp, Sergio Cesco-Cancia, Xun Li, Ahmed F. Abdel-Magid, Fuh-Rong Tsay, Scott A. Ballentine, Caterina Ferraro, Kenneth M. Wells, Christopher A. Teleha, Hua Marlon Zhong, Scott Youells, Steven J. Mehrman, Ronald K. Russell, Lorraine Scott, Jan M. Spink, Craig Diamond
Publikováno v:
Organic Process Research & Development. 19:1774-1783
The process development of Mavatrep (1), a potent transient receptor potential vanilloid-1 (TRPV1) antagonist, is described. The two key synthetic transformations are the synthesis of (E)-6-bromo-2-(4-(trifluoromethyl)styryl)1H-benzo[d]imidazole (4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d85dfd2095f7bcb55164604dce960af
https://doi.org/10.1021/acs.oprd.5b00271
https://doi.org/10.1021/acs.oprd.5b00271
Autor:
Derek A. Beauchamp, Jan M. Spink, Scott A. Ballentine, Christopher A. Teleha, Ronald K. Russell, Kenneth M. Wells, Shawn Branum, Mark R. Player, Xun Li, William V. Murray, Raymond J. Patch, Hui Huang
Publikováno v:
Organic Process Research & Development. 18:321-330
The development of a reproducible process for multihundred gram production of (Z)-5-((1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene)-3-((3R,4R)-3-fluoro-1-methylpiperidin-4-yl)thiazolidine-2,4-dione (26), a potent and selective inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88828a3d66c963401b5e0df09d341aef
https://doi.org/10.1021/op400325r
https://doi.org/10.1021/op400325r
Autor:
Kenneth M. Wells, Steven J. Mehrman, Ahmed F. Abdel-Magid, Caterina Ferraro, Lorraine Scott, Hua Marlon Zhong, Christopher A. Teleha, Scott Ballentine, Xun Li, Ronald K. Russell, Jan M. Spink, Craig Diamond, Scott Youells, Yongzheng Zhang, Fuh-Rong Tsay, Sergio Cesco-Cancia, Stephen M. Manzo, DerekA. Beauchamp
Publikováno v:
Organic Process Research & Development; Nov2015, Vol. 19 Issue 11, p1774-1783, 10p