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Akademický článek

Identification and Mechanistic Analysis of a Novel Tick-Derived Inhibitor of Thrombin.

Autor: Willy Jablonka, Michalis Kotsyfakis, Daniella M Mizurini, Robson Q Monteiro, Jan Lukszo, Steven K Drake, José M C Ribeiro, John F Andersen

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0133991 (2015)

A group of peptides from the salivary gland of the tick Hyalomma marginatum rufipes, a vector of Crimean Congo hemorrhagic fever show weak similarity to the madanins, a group of thrombin-inhibitory peptides from a second tick species, Haemaphysalis l

Externí odkaz: https://doaj.org/article/97b66389596c49fbb9ad46d643a9742b

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Akademický článek

Plasmodium falciparum infection induces expression of a mosquito salivary protein (Agaphelin) that targets neutrophil function and inhibits thrombosis without impairing hemostasis.

Autor: Michael Waisberg, Alvaro Molina-Cruz, Daniella M Mizurini, Nidhi Gera, Beatriz C Sousa, Dongying Ma, Ana C Leal, Tainá Gomes, Michalis Kotsyfakis, José M C Ribeiro, Jan Lukszo, Karine Reiter, Stephen F Porcella, Carlo J Oliveira, Robson Q Monteiro, Carolina Barillas-Mury, Susan K Pierce, Ivo M B Francischetti

Publikováno v: PLoS Pathogens, Vol 10, Iss 9, p e1004338 (2014)

Invasion of mosquito salivary glands (SGs) by Plasmodium falciparum sporozoites is an essential step in the malaria life cycle. How infection modulates gene expression, and affects hematophagy remains unclear.Using Affimetrix chip microarray, we foun

Externí odkaz: https://doaj.org/article/e7d7fadfcbb4447a92fa54705013a1c9

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Akademický článek

The epitope of monoclonal antibodies blocking erythrocyte invasion by Plasmodium falciparum map to the dimerization and receptor glycan binding sites of EBA-175.

Autor: Xavier Ambroggio, Lubin Jiang, Joan Aebig, Harold Obiakor, Jan Lukszo, David L Narum

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56326 (2013)

The malaria parasite, Plasmodium falciparum, and related parasites use a variety of proteins with Duffy-Binding Like (DBL) domains to bind glycoproteins on the surface of host cells. Among these proteins, the 175 kDa erythrocyte binding antigen, EBA-

Externí odkaz: https://doaj.org/article/b987de2104104d20be6b8b87b8a41b3f

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Akademický článek

Cyr61/CCN1 displays high-affinity binding to the somatomedin B(1-44) domain of vitronectin.

Autor: Ivo M B Francischetti, Michalis Kotsyfakis, John F Andersen, Jan Lukszo

Publikováno v: PLoS ONE, Vol 5, Iss 2, p e9356 (2010)

Cyr61 is a member of the CCN (Cyr61, connective tissue growth, NOV) family of extracellular-associated (matricellular) proteins that present four distinct functional modules, namely insulin-like growth factor binding protein (IGFBP), von Willebrand f

Externí odkaz: https://doaj.org/article/8127aa7ef9574a2595cf2406e2812efe

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Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P

Autor: Thomas L. Leto, Michael Waisberg, Balázs Rada, Jinghua Lu, Jan Lukszo, Susan K. Pierce, Louis H. Miller, Stephanie B. Yager, Ivo M.B. Francischetti, Prakash Srinivasan, Kent D. Barbian, Nidhi Gera, Gustavo C. Cerqueira, Stephen F. Porcella, Kazutoyo Miura, Najib M. El-Sayed, David L. Narum

Publikováno v: Proceedings of the National Academy of Sciences. 109:5429-5434

The malaria parasite, Plasmodium falciparum , and the human immune system have coevolved to ensure that the parasite is not eliminated and reinfection is not resisted. This relationship is likely mediated through a myriad of host–parasite interacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7a4586202e3f598a36cd7b6c48b59f
https://doi.org/10.1073/pnas.1202689109

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Definition of T cell epitopes within the 19 kDa carboxylterminal fragment of Plasmodium yoelii merozoite surface protein 1 (MSP119) and their role in immunity to malaria

Autor: Anthony A. Holder, Louis H. Miller, Jeffery Ahlers, Juan A. Cooper, David C. Kaslow, John E. Coligan, Sanjai Kumar, Chakrit Hirunpetcharat, Jan Lukszo, Michael F. Good, Irene T. Ling, Jing-Hui Tian, David C. Jackson, Jay A. Berzofsky, Allan Saul

Publikováno v: Parasite Immunology. 20:263-278

MSP119 is one of the leading malaria vaccine candidates. However, the mechanism of protection is not clear. To determine whether MSP119-specific effector T cells can control parasitaemia, we analysed the specificity of T cells induced following immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1aa94c60ed2ac2c40ae5ed71acd936f8
https://doi.org/10.1046/j.1365-3024.1998.00138.x

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Plasmodium falciparum infection induces expression of a mosquito salivary protein (Agaphelin) that targets neutrophil function and inhibits thrombosis without impairing hemostasis

Autor: Nidhi Gera, Alvaro Molina-Cruz, Michael Waisberg, Karine Reiter, Beatriz Coutinho de Sousa, Carolina Barillas-Mury, Daniella M. Mizurini, Carlo José Freire Oliveira, Jan Lukszo, Tainá Gomes, Dongying Ma, Susan K. Pierce, José M. C. Ribeiro, Robson Q. Monteiro, Ivo M.B. Francischetti, Michalis Kotsyfakis, Stephen F. Porcella, Ana C. Leal

Publikováno v: PLoS Pathogens, Vol 10, Iss 9, p e1004338 (2014)
PLoS Pathogens

Background Invasion of mosquito salivary glands (SGs) by Plasmodium falciparum sporozoites is an essential step in the malaria life cycle. How infection modulates gene expression, and affects hematophagy remains unclear. Principal Findings Using Affi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8aefabebe0329dfe859f2fb984e501
http://europepmc.org/articles/PMC4161438?pdf=render

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[Untitled]

Autor: Jan Lukszo, Gayatri Ramakrishna, Wojciech Bal, Marcin Dyba, Kazimierz S. Kasprzak, Zbigniew Szewczuk, Małgorzata Jeżowska-Bojczuk

Publikováno v: Molecular and Cellular Biochemistry. 222:97-106

The Zn(II) binding by partial peptides of human protamine HP2: HP21–15; HP21–25, HP226–40, HP237–47, and HP243–57 was studied by circular dichroism (CD). Precipitation of a 20‐mer DNA by these partial peptides and the effects of Zn(II) th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7f0704b31d966277a3565f0a1824f69
https://doi.org/10.1023/a:1017971525105

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Ni(II) Specifically Cleaves the C-Terminal Tail of the Major Variant of Histone H2A and Forms an Oxidative Damage-Mediating Complex with the Cleaved-Off Octapeptide

Autor: Rongti Liang, Miral Dizdaroglu, Kazimierz S. Kasprzak, Jan Lukszo, Sang-Han Lee, Wojciech Bal

Publikováno v: Chemical Research in Toxicology. 13:616-624

The acetyl-TESHHK-amide peptide, modeling a part of the C-terminal "tail" of histone H2A, was found previously by us to undergo at pH 7. 4 a Ni(II)-assisted hydrolysis of the E-S peptide bond with formation of a stronger Ni(II) complex with the SHHK-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ace5e0c2468709a5358fdf00de98597
https://doi.org/10.1021/tx000044l

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Mediation of Oxidative DNA Damage by Nickel(II) and Copper(II) Complexes with the N-Terminal Sequence of Human Protamine HP2

Autor: Jan Lukszo, Wojciech Bal, Kazimierz S. Kasprzak

Publikováno v: Chemical Research in Toxicology. 10:915-921

The potential of Ni(II) and Cu(II) complexes with Arg-Thr-His-Gly-Gln-Ser-His-Tyr-Arg-Arg-Arg-His-Cys-Ser-Arg-amide (HP2(1-15)), a peptide modeling the N-terminal amino acid sequence of human protamine HP2, to mediate oxidative DNA damage was studied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cac79353af64d8843d3a29535892258
https://doi.org/10.1021/tx970029p

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