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pro vyhledávání: '"Jan Lonzarić"'
Autor:
Arne Praznik, Tina Fink, Nik Franko, Jan Lonzarić, Mojca Benčina, Nina Jerala, Tjaša Plaper, Samo Roškar, Roman Jerala
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Secreted proteins, such as hormones or cytokines, are key mediators in multicellular organisms. Here the authors present two genetically encoded orthogonal regulatory secretion systems that enables inducible protein release and construction of logic
Externí odkaz:
https://doaj.org/article/ef2d00598be6446eafe33017bd693412
Akademický článek
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Autor:
Samo Roškar, Tina Fink, Arne Praznik, Nina Jerala, Jan Lonzarić, Nik Franko, Roman Jerala, Tjaša Plaper, Mojca Benčina
Publikováno v:
Nature communications. 13(1)
Secreted proteins, such as hormones or cytokines, are key mediators in multicellular organisms. Protein secretion based on transcriptional control is rather slow, as proteins requires transcription, translation, followed by the transport from the end
Autor:
Christina M. Kackos, Jennifer DeBeauchamp, Christopher J. H. Davitt, Jan Lonzaric, Robert E. Sealy, Julia L. Hurwitz, Marcelo M. Samsa, Richard J. Webby
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract Annually, seasonal influenza is responsible for millions of infections and hundreds of thousands of deaths. The current method for managing influenza is vaccination using a standardized amount of the influenza virus’ primary surface antige
Externí odkaz:
https://doaj.org/article/87d85f4bd6af44a9b0f4f155c4a9eb1c
Publikováno v:
Nucleic Acids Research
Development of orthogonal, designable and adjustable transcriptional regulators is an important goal of synthetic biology. Their activity has been typically modulated through stimulus-induced oligomerization or interaction between the DNA-binding and
Mammalian cells represent a challenge and opportunity for synthetic biology. The toolbox of regulators implemented in mammalian cells includes small molecule- or physical stimulus-responsive elements from bacteria, yeast and plants, and designed nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::972946341b9dfbe6583bd8d6e05951bc
https://doi.org/10.1039/9781782622789-00001
https://doi.org/10.1039/9781782622789-00001
Autor:
Boštjan Pirš, Andreja Majerle, Anja Golob, Miha Jerala, Vida Forstnerič, Lucija Kadunc, Dušan Vučko, Rok Gaber, Jan Lonzarić, Urban Bezeljak, Mojca Benčina, Tina Lebar, Anže Smole, Alja Oblak, Roman Jerala, Martin Stražar, Uroš Zupančič
Publikováno v:
Nature Communications. 5
Bistable switches are fundamental regulatory elements of complex systems, ranging from electronics to living cells. Designed genetic toggle switches have been constructed from pairs of natural transcriptional repressors wired to inhibit one another.
Autor:
Roman Jerala, Tjaša Plaper, Arne Praznik, Fabio Lapenta, Mojca Benčina, Tina Lebar, Jan Lonzarić, Katja Leben, Nina Jerala, Tina Fink, Estera Merljak, Žiga Strmšek
Publikováno v:
Nature Chemical Biology
Nat Chem Biol
Nat Chem Biol
Cellular signal transduction is predominantly based on protein interactions and their post-translational modifications, which enable a fast response to input signals. Owing to difficulties in designing new unique protein-protein interactions, designe