Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jan Laczo"'
Autor:
Omar Šerý, Tomáš Zeman, Kateřina Sheardová, Martin Vyhnálek, Hana Marková, Jan Laczó, Jan Lochman, Petr Kralik, Kamila Vrzalová, Radka Dziedzinska, Vladimir J. Balcar, Jakub Hort
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The risk of Alzheimer’s disease (AD) has a strong genetic component, also in the case of late-onset AD (LOAD). Attempts to sequence whole genome in large populations of subjects have identified only a few mutations common to most of the pa
Externí odkaz:
https://doaj.org/article/24a017abd28b4ce8bfe214e01c00fe4a
Autor:
Jana Amlerova, Jan Laczó, Zuzana Nedelska, Martina Laczó, Martin Vyhnálek, Bing Zhang, Kateřina Sheardova, Francesco Angelucci, Ross Andel, Jakub Hort
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-8 (2022)
Abstract Background The ability to understand emotions is often disturbed in patients with cognitive impairments. Right temporal lobe structures play a crucial role in emotional processing, especially the amygdala, temporal pole (TP), superior tempor
Externí odkaz:
https://doaj.org/article/c4fcce484e22402aad249e197f4a7942
Autor:
Monica E. Nelson, Britney M. Veal, Ross Andel, Julie Martinkova, Katerina Veverova, Hana Horakova, Zuzana Nedelska, Jan Laczó, Martin Vyhnalek, Jakub Hort
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
BackgroundDementia syndrome is one of the most devastating conditions in older adults. As treatments to stop neurodegeneration become available, accurate and timely diagnosis will increase in importance. One issue is that cognitive performance someti
Externí odkaz:
https://doaj.org/article/f9146ad75d4849128f44f7bbf8528b70
Autor:
Martina Laczó, Lukas Martinkovic, Ondrej Lerch, Jan M. Wiener, Jana Kalinova, Veronika Matuskova, Zuzana Nedelska, Martin Vyhnalek, Jakub Hort, Jan Laczó
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
BackgroundSpatial navigation impairment is a promising cognitive marker of Alzheimer’s disease (AD) that can reflect the underlying pathology.ObjectivesWe assessed spatial navigation performance in AD biomarker positive older adults with amnestic m
Externí odkaz:
https://doaj.org/article/7c44dd1853134cd19d6ea0697f66cb34
Autor:
Veronika Matuskova, Zahinoor Ismail, Tomas Nikolai, Hana Markova, Katerina Cechova, Zuzana Nedelska, Jan Laczó, Meng Wang, Jakub Hort, Martin Vyhnalek
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Externí odkaz:
https://doaj.org/article/4fdbb6ca253b48b6930bb27c62b7d328
Autor:
Martina Laczó, Ondrej Lerch, Lukas Martinkovic, Jana Kalinova, Hana Markova, Martin Vyhnalek, Jakub Hort, Jan Laczó
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Background: The hippocampus, entorhinal cortex (EC), and basal forebrain (BF) are among the earliest regions affected by Alzheimer’s disease (AD) pathology. They play an essential role in spatial pattern separation, a process critical for accurate
Externí odkaz:
https://doaj.org/article/cbec0812a0db4f8798f34506e58a624d
Autor:
Veronika Matuskova, Zahinoor Ismail, Tomas Nikolai, Hana Markova, Katerina Cechova, Zuzana Nedelska, Jan Laczó, Meng Wang, Jakub Hort, Martin Vyhnalek
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
ObjectivesMild behavioral impairment (MBI) is a syndrome describing late-onset persistent neuropsychiatric symptoms (NPS) in non-demented older adults. Few studies to date have investigated the associations of MBI with structural brain changes. Our a
Externí odkaz:
https://doaj.org/article/ef3a7c16f734487ab0f3d627859b9c5a
Autor:
Martina Laczó, Jan M. Wiener, Jana Kalinova, Veronika Matuskova, Martin Vyhnalek, Jakub Hort, Jan Laczó
Publikováno v:
Brain Sciences, Vol 11, Iss 11, p 1421 (2021)
Age-related spatial navigation decline is more pronounced in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia. We used a realistic-looking virtual navigation test suite to analyze different aspects of visuospatial
Externí odkaz:
https://doaj.org/article/226695d8bee7423f8e07dd7d8bd1157a
Autor:
Eva Hyncicova, Adam Kalina, Martin Vyhnalek, Tomas Nikolai, Lukas Martinkovic, Jiri Lisy, Jakub Hort, Eva Meluzinova, Jan Laczó
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200254 (2018)
BACKGROUND:Neuropsychiatric symptoms and reduced health-related quality of life (HRQoL) are frequent in multiple sclerosis, where are associated with structural brain changes, but have been less studied in clinically isolated syndrome (CIS). OBJECTIV
Externí odkaz:
https://doaj.org/article/cad3b6771cd74041878d8dc81bc0c3be
Autor:
Katerina Sheardova, Jan Laczó, Martin Vyhnalek, Ross Andel, Ivana Mokrisova, Kamil Vlcek, Jana Amlerova, Jakub Hort
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105623 (2014)
BACKGROUND:Identification of famous landmarks (FLI), famous faces (FFI) and recognition of facial emotions (FER) is affected early in the course of Alzheimer's disease (AD). FFI, FER and FLI may represent domain specific tasks relying on activation o
Externí odkaz:
https://doaj.org/article/d08143bcec6d4eb8af915ac861fe72ae