Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jan L. Wahlstrom"'
Publikováno v:
Drug Metabolism and Disposition. 50:600-612
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e58aabc5dfac2c30f80ad7fee27c19b9
https://doi.org/10.1124/dmd.121.000798
https://doi.org/10.1124/dmd.121.000798
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 50(5)
Sotorasib is a first-in-class, targeted covalent inhibitor of Kirsten rat sarcoma viral oncogene homolog (KRAS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::93cc36a2c23298a8a9bfb866a3e35210
https://pubmed.ncbi.nlm.nih.gov/35153196
https://pubmed.ncbi.nlm.nih.gov/35153196
Autor:
Larry C. Wienkers, Jan L. Wahlstrom
Publikováno v:
Drug Discovery and Evaluation: Methods in Clinical Pharmacology ISBN: 9783319566375
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d809e45e378bfafdb0ad16f607e85b25
https://doi.org/10.1007/978-3-319-56637-5_14-1
https://doi.org/10.1007/978-3-319-56637-5_14-1
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 13:145-158
Advances in drug interaction screening have resulted in reduced compound attrition rates due to unfavorable CYP-mediated drug interactions in clinical trials and improved patient safety. A major driver for the success in predicting drug interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c84309abd50d487e49c802f59fdaab7
https://doi.org/10.2174/138620710790596718
https://doi.org/10.2174/138620710790596718
Autor:
Steven L. Roberds, Steve P. Wene, Mark E. Smith, Chad J. Warren, Shuxia Zhou, Denise K. Pretzer, Jan L. Wahlstrom, Jon G. Selbo, Po-Chang Chiang, Sarbani Ghosh, L. Lena Zhang, Lesley A. Albin
Publikováno v:
Journal of Experimental Nanoscience. 2:239-250
Aqueous insolubility is recognized throughout the pharmaceutical industry as a major hurdle for pre-clinical and clinical drug delivery. Pre-clinical, early efficacy, and proof of concept studies oftentimes rely on model compounds that have less than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f38ef66e1371ae21d0841d7a053646fa
https://doi.org/10.1080/17458080601134540
https://doi.org/10.1080/17458080601134540
Autor:
Sarbani Ghosh, Mark E. Smith, Jan L. Wahlstrom, Lesley A. Albin, Steven L. Roberds, Steve P. Wene, Chad J. Warren, Po-Chang Chiang
Publikováno v:
Nanoscale Research Letters
Nanoscale Research Letters, Vol 2, Iss 6, Pp 291-296 (2007)
Nanoscale Research Letters, Vol 2, Iss 6, Pp 291-296 (2007)
Time and resource constraints necessitate increasingly early decisions to advance or halt pre-clinical drug discovery programs. Early discovery or “tool” compounds may be potent inhibitors of new targets, but all too often they exhibit poor pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18154d324f6be5bc26c9e6e80c994563
http://europepmc.org/articles/PMC3246351
http://europepmc.org/articles/PMC3246351
The in Vitro Drug Interaction Potential of Dietary Supplements Containing Multiple Herbal Components
Publikováno v:
Drug Metabolism and Disposition. 35:185-188
Herbal-based remedies are widely used as alternative treatments for a number of ailments. In addition, the use of products that contain both single and multiple herbal constituents is becoming increasingly common. The work described in this report ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd1563b9073185dc24915f53e26e12d
https://doi.org/10.1124/dmd.106.012724
https://doi.org/10.1124/dmd.106.012724
Publikováno v:
Drug Metabolism and Disposition. 34:1523-1529
The mechanism behind the observed inactivation of human P450 2B6 by phencyclidine (PCP) has been evaluated over the past 2 decades. The scope of the current investigation was to contribute to the fundamental knowledge of PCP oxidation and perhaps the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5619c6b635fd01d819d3edd838416b7c
https://doi.org/10.1124/dmd.106.010579
https://doi.org/10.1124/dmd.106.010579
Publikováno v:
Archives of Biochemistry and Biophysics. 416:9-16
A number of enzymes from the cytochrome P450 family show atypical (non-Michaelis-Menten) kinetic behavior resulting from substrate activation, inhibition, partial inhibition, biphasic saturation, or autoactivation. Herein, we provide a technique that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a77523207bef4e249ca8d9e1ea08404
https://doi.org/10.1016/s0003-9861(03)00228-5
https://doi.org/10.1016/s0003-9861(03)00228-5
Publikováno v:
Bioorganic Chemistry. 30:107-118
The substrate oxidation rates of P450 BM-3 are unparalleled in the cytochrome P450 (CYP) superfamily of enzymes. Furthermore, the bacterial enzyme, originating from Bacillus megaterium , has been used repeatedly as a model to study the metabolism of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24c8b822da2e32de4afc88843c086d5
https://doi.org/10.1006/bioo.2002.1239
https://doi.org/10.1006/bioo.2002.1239