Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jan L. Hillson"'
Autor:
Jing Yang, Jason D. Lickliter, Jan L. Hillson, Gary D. Means, Russell J. Sanderson, Kay Carley, Almudena Tercero, Kristi L. Manjarrez, Jennifer R. Wiley, Stanford L. Peng
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 4, Pp 1314-1326 (2021)
Abstract ALPN‐101 (ICOSL vIgD‐Fc) is an Fc fusion protein of a human inducible T cell costimulatory ligand (ICOSL) variant immunoglobulin domain (vIgD) designed to inhibit the cluster of differentiation 28 (CD28) and inducible T cell costimulator
Externí odkaz:
https://doaj.org/article/701f4101ee394f428fca2532c07f1b57
Autor:
Victor Farutin, Thomas Prod’homme, Kevin McConnell, Nathaniel Washburn, Patrick Halvey, Carol J. Etzel, Jamey Guess, Jay Duffner, Kristen Getchell, Robin Meccariello, Bryan Gutierrez, Christopher Honan, Ganlin Zhao, Nicholas A. Cilfone, Nur Sibel Gunay, Jan L. Hillson, David S. DeLuca, Katherine C. Saunders, Dimitrios A. Pappas, Jeffrey D. Greenberg, Joel M. Kremer, Anthony M. Manning, Leona E. Ling, Ishan Capila
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-14 (2019)
Abstract Background The goal of this study is to use comprehensive molecular profiling to characterize clinical response to anti-TNF therapy in a real-world setting and identify reproducible markers differentiating good responders and non-responders
Externí odkaz:
https://doaj.org/article/3e82234a9ea54de3a35f19b6cf0f9913
Development of the Antibody Repertoire as Revealed by Single-Cell PCR of FACS-Sorted B-Cell Subsetsa
Autor:
John D. MacKenzie, Leonore A. Herzenberg, Aaron B. Kantor, Cynthia E. Merrill, Jan L. Hillson
Publikováno v:
Annals of the New York Academy of Sciences. 764:224-227
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33df8f6257dce2d087294241728fe364
https://doi.org/10.1111/j.1749-6632.1995.tb55831.x
https://doi.org/10.1111/j.1749-6632.1995.tb55831.x
Autor:
Jan L. Hillson, Daniel E. Furst
Publikováno v:
Rheumatic Disease Clinics of North America. 23:757-778
Methotrexate (MTX) is among the most effective drugs for treatment of rheumatoid arthritis (RA) and has proven valuable in the treatment of multiple other disorders of immune regulation. Methotrexate has been administered at a wide range of doses and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e08ffb3e81f01d52b29cc4dd15206f4
https://doi.org/10.1016/s0889-857x(05)70359-8
https://doi.org/10.1016/s0889-857x(05)70359-8
Publikováno v:
Arthritis and rheumatism. 65(6)
Clinical trials of therapies for lupus nephritis have used many different primary outcome measures, ranging from complete response to time to end-stage renal disease. The objective of this study was to compare several possible outcome measures, using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd7a628952a0c7dabf27e09ea95e9d3c
https://pubmed.ncbi.nlm.nih.gov/23529285
https://pubmed.ncbi.nlm.nih.gov/23529285
Autor:
Roger M. Perlmutter, Jan L. Hillson
Publikováno v:
International Reviews of Immunology. 5:215-229
Developing fetal B cells preferentially rearrange a restricted subset of the encoded antibody gene segments. There are striking structural similarities between elements expressed early in man and in mouse, most evident on comparison of murine VH elem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99764a7c3b2a5f0672f4de216378c084
https://doi.org/10.3109/08830189009056730
https://doi.org/10.3109/08830189009056730
Publikováno v:
The Journal of Experimental Medicine
The ability of human VH3 immunoglobulins (Ig) to bind to staphylococcal protein A (SPA) via their Fab region is analogous to the binding of bacterial superantigens to T cell receptors. The present report establishes the structural basis for the inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0444aaeb653633418d8f063363d44f7
https://pubmed.ncbi.nlm.nih.gov/8315388
https://pubmed.ncbi.nlm.nih.gov/8315388
Publikováno v:
International immunology. 2(1)
Antibodies are encoded by a limited number of germline gene segments that undergo somatic diversification through rearrangement and mutation. Because these mutation processes are efficient, it is widely believed that there is little environmental sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98b89c778da05247eedeeb0ea753c52
https://pubmed.ncbi.nlm.nih.gov/2128464
https://pubmed.ncbi.nlm.nih.gov/2128464
Publikováno v:
Science. 238:791-793
Diversification of the antibody repertoire in mammals results from a series of apparently random somatically propagated gene rearrangement and mutational events. Nevertheless, it is well known that the adult repertoire of antibody specificities is ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be389c3328b3290fe67cc8e306b9831b
https://doi.org/10.1126/science.3118465
https://doi.org/10.1126/science.3118465