Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jan Kueckelhaus"'
Autor:
Jan Kueckelhaus, Simon Frerich, Jasim Kada-Benotmane, Christina Koupourtidou, Jovica Ninkovic, Martin Dichgans, Juergen Beck, Oliver Schnell, Dieter Henrik Heiland
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Spatially resolved transcriptomics has revolutionized RNA studies by aligning RNA abundance with tissue structure, enabling direct comparisons between histology and gene expression. Traditional approaches to identifying signature genes often
Externí odkaz:
https://doaj.org/article/5ddb7137c89d4ed887c861114fc3f3b6
Autor:
Jasim Kada Benotmane, Jan Kueckelhaus, Paulina Will, Junyi Zhang, Vidhya M. Ravi, Kevin Joseph, Roman Sankowski, Jürgen Beck, Catalina Lee-Chang, Oliver Schnell, Dieter Henrik Heiland
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Spatial resolution of the T cell repertoire is essential for deciphering cancer-associated immune dysfunction. Current spatially resolved transcriptomic technologies are unable to directly annotate T cell receptors (TCR). We present spatiall
Externí odkaz:
https://doaj.org/article/3bbd27aa3be14c8cb9783f3bdb460db0
Autor:
Julian P. Maier, Vidhya M. Ravi, Jan Kueckelhaus, Simon P. Behringer, Niklas Garrelfs, Paulina Will, Na Sun, Jasmin von Ehr, Jonathan M. Goeldner, Dietmar Pfeifer, Marie Follo, Luciana Hannibal, Axel Karl Walch, Ulrich G. Hofmann, Jürgen Beck, Dieter Henrik Heiland, Oliver Schnell, Kevin Joseph
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Abstract Glioblastoma (GBM), the most malignant tumor of the central nervous system, is marked by its dynamic response to microenvironmental niches. In particular, this cellular plasticity contributes to the development of an immediate resistance dur
Externí odkaz:
https://doaj.org/article/b89ed836d7234b6e8298f323cfead154
Autor:
David Hou, Brandyn Castro, Mark Dapash, Andrew Zolp, Joshua Katz, Víctor Arrieta, Jana Biermann, Johannes Melms, Jan Kueckelhaus, Jasim Benotmane, Mark Youngblood, Aida Rashidi, Leah Billingham, Crismita Dmello, Gustavo Vazquez-Cervantes, Aurora Lopez-Rosas, Yu Han, Ronit Patel, Tzu-yi Chia, Lu Sun, Robert Prins, Benjamin Izar, Deiter Henrik Heiland, Peng Zhang, Adam Sonabend, Jason Miska, Maciej Lesniak, Junfei Zhao, Catalina Lee-Chang
Immunotherapy has revolutionized cancer treatment but has yet to be translated into brain tumors. Studies in other solid tumors suggest a central role of B-cell immunity in driving immune-checkpoint-blockade efficacy. Using single-cell and single-nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e32cb92415093d868bed4ef4d99df7
https://doi.org/10.21203/rs.3.rs-2399170/v1
https://doi.org/10.21203/rs.3.rs-2399170/v1
Autor:
Simon P Behringer, Vidhya M Ravi, Oliver Schnell, Jasim Kada Benotmane, Henrike Salié, Marie Follo, Daniel Delev, Marius Schwabenland, Ulrich G. Hofmann, Melanie Boerries, Jonathan M Goeldner, Mohammed Khiat, Christian Fung, Manching Ku, Axel Walch, Jürgen Beck, Dieter Henrik Heiland, Ugne Kuliesiute, Florian Scherer, Ulrich Schüller, Paulina Will, Lea Vollmer, Na Sun, Pamela Franco, Roman Sankowski, Jasmin von Ehr, Kevin Joseph, Marco Prinz, Katrin Lamszus, Franz Ricklefs, Junyi Zhang, Jan Kueckelhaus, Saskia Killmer, Nicolas Neidert, Bertram Bengsch
Publikováno v:
Cancer cell, Cambridge, MA : Cell Press, 2022, vol. 40, iss. 6, p. 639-655, e1-e13
Cancer Cell 40, 639-655.e13 (2022)
Cancer Cell 40, 639-655.e13 (2022)
Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of the dynamic reorganization within the spatial context of these tumors remains elus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3e8ee4dd63c97972bea35b3546493e
https://repository.vu.lt/VU:ELABAPDB139646810&prefLang=en_US
https://repository.vu.lt/VU:ELABAPDB139646810&prefLang=en_US
Publikováno v:
Neuro-Oncology. 24:vii277-vii277
Regional diversity of anti-tumor immunity in glioblastoma (GBM) has been poorly investigated due to technical limitations. To overcome these hurdles, we developed SPTCR-seq (SPatial TCell Receptor sequencing) to spatially profile T cell immune respon
Autor:
Vidhya Ravi, Simon Behringer, Kevin Joseph, Luciana Haniball, Jan Kueckelhaus, Paulina Will, Nicolas Neidert, Jonathan Goeldner, Pamela Franco, Christian Fung, Juergen Beck, Roman Sankowski, Marco Prinz, Ulrich Hofmann, Oliver Schnell, Dieter Henrik Heiland
Reactive transformation of astrocytes in IDH wild-type glioma contribute to anti-tumor immunity and support pro-oncogenic signaling. The role of intra- and peritumoral astrocytes in IDH1/2 mutated glioma, a prognostically beneficial subgroup with onc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b561a91818892df99104a4a78f748bfa
https://doi.org/10.21203/rs.3.rs-720962/v1
https://doi.org/10.21203/rs.3.rs-720962/v1
Autor:
Vidhya M. Ravi, Paulina Will, Jan Kueckelhaus, Na Sun, Kevin Joseph, Henrike Salié, Jasmin von Ehr, Lea Vollmer, Jasim K. Benotmane, Nicolas Neidert, Marie Follo, Florian Scherer, Jonathan M Goeldner, Simon P. Behringer, Pamela Franco, Ulrich G. Hofmann, Christian Fung, Jürgen Beck, Roman Sankowski, Marco Prinz, Saskia Killmer, Bertram Bengsch, Axel Karl Walch, Daniel Delev, Oliver Schnell, Dieter Henrik Heiland
Glioblastomas are highly malignant tumors of the central nervous system. Evidence suggests that these tumors display large intra- and inter-patient heterogeneity hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54c363038a378ba4957da7d5adc0078b
https://doi.org/10.1101/2021.02.16.431475
https://doi.org/10.1101/2021.02.16.431475
Autor:
Erdem Güresir, Mohummad Aminur Rahman, Dieter Henrik Heiland, Oliver Schnell, Shahin Sarowar, David Zurhorst, Andreas Dolf, Anna-Laura Potthoff, Martha Chekenya, Hartmut Vatter, Nicolas Neidert, Paolo Salomoni, Vidhya M Ravi, Julian P Maier, Bernd O. Evert, Per Øyvind Enger, Jan Kueckelhaus, Kevin Joseph, Mike-Andrew Westhoff, Paulina Will, Ulrich Herrlinger, Ulrich G. Hofmann, Torsten Pietsch, Lea Vollmer, Jürgen Beck, Matthias Schneider, Andreas Waha, Melanie Meyer-Luehmann, Patrick Schuss, Paolo d'Errico
Publikováno v:
Neuro-Oncology 23(11), 1885-1897 (2021). doi:10.1093/neuonc/noab092
Background Glioblastoma cells assemble to a syncytial communicating network based on tumor microtubes (TMs) as ultra-long membrane protrusions. The relationship between network architecture and transcriptional profile remains poorly investigated. Dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b501861f5734fd45a4f29f61b4053c46
https://pub.dzne.de/record/155744
https://pub.dzne.de/record/155744
Autor:
Jasmin von Ehr, Juergen Beck, Ulrich G. Hofmann, Dieter Henrik Heiland, Daniel Delev, Kevin Joseph, Jan Kueckelhaus, Paulina Will, Oliver Schnell, Vidhya M Ravi
Spatial transcriptomic is a technology to provide deep transcriptomic profiling by preserving the spatial organization. Here, we present a framework for SPAtial Transcriptomic Analysis (SPATA, https://themilolab.github.io/SPATA), to provide a compreh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::273f10ed72148303cd02e37c33ad5c40
https://doi.org/10.1101/2020.10.20.346544
https://doi.org/10.1101/2020.10.20.346544