Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jan Kubovčiak"'
Autor:
Helena Gbelcová, Silvie Rimpelová, Adriana Jariabková, Patrik Macášek, Petra Priščáková, Tomáš Ruml, Jana Šáchová, Jan Kubovčiak, Michal Kolář, Libor Vítek
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Statins, the drugs used for the treatment of hypercholesterolemia, have come into the spotlight not only as chemoadjuvants, but also as potential stem cell modulators in the context of regenerative therapy. In our study, we compared the in v
Externí odkaz:
https://doaj.org/article/a2b1444916ff47fd88579fb1c2a86160
Autor:
Michaela Šímová, Carlos Eduardo Madureira Trufen, Iva Šplíchalová, Jan Kubovčiak, Michal Kolář, Vendula Novosadová, Jan Procházka, Dominik Filipp, Radislav Sedláček, Jana Balounová
Publikováno v:
HemaSphere, Vol 7, p e2843053 (2023)
Externí odkaz:
https://doaj.org/article/4e20b105a8114812b51812c9b1ab3fc7
Autor:
Lucie Schmiedová, Jakub Kreisinger, Jan Kubovčiak, Martin Těšický, Jean-Francois Martin, Oldřich Tomášek, Tereza Kauzálová, Ondřej Sedláček, Tomáš Albrecht
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
IntroductionDecreasing biotic diversity with increasing latitude is an almost universal macroecological pattern documented for a broad range of taxa, however, there have been few studies focused on changes in gut microbiota (GM) across climatic zones
Externí odkaz:
https://doaj.org/article/111a874850fa4a9397cd238bb743831f
Autor:
Kristýna Olbertová, Dušan Hrčkulák, Vítězslav Kříž, Wojciech Jesionek, Jan Kubovčiak, Milan Ešner, Vladimír Kořínek, Marcela Buchtová
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Leucine Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5), a Wnt pathway member, has been previously recognised as a stem cell marker in numerous epithelial tissues. In this study, we used Lgr5-EGFP-CreERT2 mice to analyse the distribution o
Externí odkaz:
https://doaj.org/article/7b897f4f30fb4e24af974f371b03b687
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Sertoli cells (SCs) are the only somatic cells that reside in seminiferous tubules of testis. They directly interact with and support the development of germ cells, thus have an indispensable role in the process of spermatogenesis. SCs first appear i
Externí odkaz:
https://doaj.org/article/90fca3b4a76f40adbac3562d274f88e4
Autor:
Jan Kubovčiak, Lucie Schmiedová, Tomáš Albrecht, Martin Těšický, Oldřich Tomášek, Tereza Kauzálová, Jakub Kreisinger
Publikováno v:
Ecology and Evolution, Vol 12, Iss 7, Pp n/a-n/a (2022)
Abstract Gut microbiota (GM) often exhibit variation between different host species and co‐divergence with hosts' phylogeny. Identifying these patterns is a key for understanding the mechanisms that shaped symbiosis between GM and its hosts. Theref
Externí odkaz:
https://doaj.org/article/ea91bbe31ecc4ed99f9b77e5254879a6
Autor:
Matouš Vobořil, Tomáš Brabec, Jan Dobeš, Iva Šplíchalová, Jiří Březina, Adéla Čepková, Martina Dobešová, Aigerim Aidarova, Jan Kubovčiak, Oksana Tsyklauri, Ondřej Štěpánek, Vladimír Beneš, Radislav Sedláček, Ludger Klein, Michal Kolář, Dominik Filipp
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Immune tolerance is mediated by the deletion of autoreactive T cells via medullary thymic epithelial cells (mTEC) and dendritic cells (DC), and by the induction of regulatory T cells (Treg). Here the authors show that mTEC receiving toll-like recepto
Externí odkaz:
https://doaj.org/article/17ae763d83f941499c6713566243bf8e
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0265742 (2022)
Retinitis pigmentosa (RP) is a hereditary disease affecting tens of thousands of people world-wide. Here we analyzed the effect of an amino acid substitution in the RNA helicase DHX38 (Prp16) causing RP. DHX38 has been proposed as the helicase import
Externí odkaz:
https://doaj.org/article/97b72106a67046f88e9acd09c2a7c0d1
Autor:
Jan Šilhavý, Petr Mlejnek, Miroslava Šimáková, František Liška, Jan Kubovčiak, Eva Sticová, Michal Pravenec
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 376 (2022)
Recent studies in humans and rats suggested that increased Na+ storage in the skin without parallel water retention may predispose to salt-sensitive hypertension. In the current studies, we compared tissue Na+ storage in salt sensitive spontaneously
Externí odkaz:
https://doaj.org/article/5e0b08e4eecc489ca1a59dcca1f27994
Autor:
Anna Markos, Jan Kubovciak, Simona Mikula Mrstakova, Anna Zitova, Jan Paces, Simona Machacova, Zbynek Kozmik-Jr, Zbynek Kozmik, Iryna Kozmikova
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract To shed light on the enigmatic origin of the vertebrate head, our study employs an integrated approach that combines single-cell transcriptomics, perturbations in signaling pathways, and cis-regulatory analysis in amphioxus. As a representat
Externí odkaz:
https://doaj.org/article/fddd25ac5d8b484b8335ef8f7cf02273