Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jan Krusek"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 152, Iss , Pp 113262- (2022)
Transient receptor potential canonical 5 (TRPC5) is a polymodal, calcium-permeable, nonselective ion channel that is expressed in the brain and 75 % of human sensory neurons. Its pharmacological or genetic inhibition leads to the relief of neuropathi
Externí odkaz:
https://doaj.org/article/72780a74f149476e9d9dbe9056d9728d
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
N-methyl-D-aspartate receptors (NMDARs) mediate excitatory synaptic transmission in the central nervous system, underlie the induction of synaptic plasticity, and their malfunction is associated with human diseases. Native NMDARs are tetramers compos
Externí odkaz:
https://doaj.org/article/b7fdc504c10241d1aa8988326b94064a
Autor:
Eva Kudova, Barbora Krausova, Ladislav Vyklicky, Jan Krusek, Tereza Smejkalova, Hana Chodounska, Dragana Hajdukovic, Miriam Candelas Serra, Miloslav Korinek
Publikováno v:
British Journal of Pharmacology
Background and purpose Neurosteroids influence neuronal function and have multiple promising clinical applications. Direct modulation of postsynaptic neurotransmitter receptors by neurosteroids is well characterized, but presynaptic effects remain po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759a84b81c9af5633d8a9c074bbc9eca
https://doi.org/10.1111/bph.15529
https://doi.org/10.1111/bph.15529
Autor:
Jiri Cerny, Ladislav Vyklicky, Barbora Krausova, Zaneta Naimová, Marek Ladislav, Miloslav Korinek, Jan Krusek, Bohdan Kysilov, Eva Kudova, Pavla Hubalkova, Vojtech Vyklicky, Tereza Smejkalova, Hana Chodounska
Publikováno v:
J Neurosci
NMDARs are ligand-gated ion channels that cause an influx of Na+and Ca2+into postsynaptic neurons. The resulting intracellular Ca2+transient triggers synaptic plasticity. When prolonged, it may induce excitotoxicity, but it may also activate negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844eb8adb59ea5add8fb3221621f28ff
https://doi.org/10.1523/jneurosci.2654-20.2021
https://doi.org/10.1523/jneurosci.2654-20.2021
Autor:
Ladislav Vyklicky, Inmaculada M. Gonzalez-Gonzalez, Martin Horak, Dragana Hajdukovic, Jan Krusek, Tereza Smejkalova, Kristyna Skrenkova, Miloslav Korinek
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports
Scientific Reports
Cholesterol is a structural component of cellular membranes particularly enriched in synapses but its role in synaptic transmission remains poorly understood. We used rat hippocampal cultures and their acute cholesterol depletion by methyl-β-cyclode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a349691a4dd3c5652357fc5f4a5a1bc4
https://doi.org/10.1038/s41598-020-69454-5
https://doi.org/10.1038/s41598-020-69454-5
Publikováno v:
Journal of Cellular and Molecular Medicine
Exposure to repetitive low‐frequency electromagnetic field (LF‐EMF) shows promise as a non‐invasive approach to treat various sensory and neurological disorders. Despite considerable progress in the development of modern stimulation devices, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a904a4f0c6d0f20640ff976e93531dd4
http://europepmc.org/articles/PMC5783861
http://europepmc.org/articles/PMC5783861
Autor:
Martina Kaniakova, Ondrej Soukup, Jan Krusek, Martin Horak, Eugenie Nepovimova, Kristina Holubova, Jan Ricny, Ladislav Vyklicky, Ales Stuchlik, Kamil Kuca, Karel Vales, Jan Korabecny
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 75:54-62
The mechanism of tacrine as a precognitive drug has been considered to be complex and not fully understood. It has been reported to involve a wide spectrum of targets involving cholinergic, gabaergic, nitrinergic and glutamatergic pathways. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b050aa53be72904ed4caa02bf111456e
https://doi.org/10.1016/j.pnpbp.2017.01.003
https://doi.org/10.1016/j.pnpbp.2017.01.003
Autor:
Ivan Dittert, Jan Krusek, Vladimira Petrakova, Hana Freislebenová, Kristyna Gottftriedova, Andrew Taylor, Veronika Benson, Tereza Smejkalova, Vaclav Petrak, Eva Neuhöferová, Vincent Mortet, Miloslav Korinek
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac0ca85a21dc70bfd3221e106611a643
https://doi.org/10.1096/fasebj.2019.33.1_supplement.706.3
https://doi.org/10.1096/fasebj.2019.33.1_supplement.706.3
Autor:
Martin Horak, Ales Balik, Jan Krusek, Ladislav Vyklicky, Barbora Krausova, Jirina Borovska, Vojtech Vyklicky, Tereza Smejkalova, Katarina Lichnerova, Martina Kaniakova, Miloslav Korinek
Publikováno v:
The Journal of Physiology. 593:2279-2293
NMDA receptors (NMDARs) are glutamate-gated ion channels that mediate excitatory neurotransmission in the CNS. Although these receptors are in direct contact with plasma membrane, lipid-NMDAR interactions are little understood. In the present study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e9eebae80d47c9dfd27de6c321b19c9
https://doi.org/10.1113/jphysiol.2014.288209
https://doi.org/10.1113/jphysiol.2014.288209
Autor:
Vendula Sepsova, Jana Z. Karasova, Gunnar Tobin, Daniel Jun, Jan Korabecny, Pavla Cabelova, Katerina Janska, Jan Krusek, Kristyna Skrenkova, Kamil Kuca, Marian Valko, Ondrej Soukup
Publikováno v:
General physiology and biophysics. 34:189-200
Organophosphorus nerve agents inhibit acetylcholinesterase (AChE) which causes the breakdown of the transmitter acetylcholine (ACh) in the synaptic cleft. Overstimulation of cholinergic receptors (muscarinic and nicotinic) by excessive amounts of ACh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e44b449b4d3fb23c68a183e47f06e29
https://doi.org/10.4149/gpb_2014036
https://doi.org/10.4149/gpb_2014036