Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Jan Kovar"'
Autor:
Jan Benes, Martin Kotrc, Katerina Kroupova, Peter Wohlfahrt, Jan Kovar, Janka Franekova, Marketa Hegarova, Lenka Hoskova, Eva Hoskova, Terezie Pelikanova, Petr Jarolim, Josef Kautzner, Vojtech Melenovsky
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The role of metformin (MET) in the treatment of patients with advanced HFrEF and type 2 diabetes mellitus (DM) is not firmly established. We studied the impact of MET on metabolic profile, quality of life (QoL) and survival in these patients
Externí odkaz:
https://doaj.org/article/18cc780595cf44aca2cc2ffd0ab7a132
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0229430 (2020)
Many compounds have the potential to harm pancreatic beta-cells; organochlorine pollutants belong to those compounds. In this work, we aimed to find markers of acute toxicity of p,p'-DDT exposure among proteins expressed in NES2Y human pancreatic bet
Externí odkaz:
https://doaj.org/article/b38b8261bc2243ebaf679b8ab5d548ea
Autor:
Martina Musutova, Moustafa Elkalaf, Natalie Klubickova, Michal Koc, Stanislav Povysil, Jan Rambousek, Beatriz Volckaert, Frantisek Duska, Minh Duc Trinh, Martin Kalous, Jan Trnka, Kamila Balusikova, Jan Kovar, Jan Polak
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Metabolic impairments associated with obstructive sleep apnea syndrome (OSA) are linked to tissue hypoxia, however, the explanatory molecular and endocrine mechanisms remain unknown. Using gas-permeable cultureware, we studied the chronic effects of
Externí odkaz:
https://doaj.org/article/a805d61445054cef83f2a172caf065c2
Autor:
Vojtech Melenovsky, Jan Benes, Janka Franekova, Jan Kovar, Barry A. Borlaug, Marketa Segetova, Andrea Tura, Tereza Pelikanova
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 8 (2017)
BackgroundThe mechanisms and relevance of impaired glucose homeostasis in advanced heart failure (HF) are poorly understood. The study goals were to examine glucose regulation, pancreatic endocrine function, and metabolic factors related to prognosis
Externí odkaz:
https://doaj.org/article/7d2eed13d5cb48cb8c0e1bffdb9af4c2
Autor:
Jan Kovar
Publikováno v:
Romanian Journal of European Affairs, Vol 13, Iss 1, Pp 57-82 (2013)
This paper attempts to contribute to the debate on the Europeanization of European Parliament elections. Because these elections are supposedly fought over national political issues, the analysis focuses on one aspect of political parties' supply for
Externí odkaz:
https://doaj.org/article/af71fa84492b490c956a40c775f2c0bd
Autor:
Martin Weiszenstein, Nela Pavlikova, Moustafa Elkalaf, Petr Halada, Ondrej Seda, Jan Trnka, Jan Kovar, Jan Polak
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152382 (2016)
Pericellular oxygen concentration represents an important factor in the regulation of cell functions, including cell differentiation, growth and mitochondrial energy metabolism. Hypoxia in adipose tissue has been associated with altered adipokine sec
Externí odkaz:
https://doaj.org/article/0f19a7a276ce426f84eb141d8958f6ec
Autor:
Radka Vaclavikova, Karolina Seborova, Alzbeta Spalenkova, Marie Ehrlichova, Iwao Ojima, Petr Daniel, Jan Kovar, Pavel Soucek
Publikováno v:
E-Posters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d21f7beefe183ad07474291da753f4f
https://doi.org/10.1136/ijgc-2022-igcs.109
https://doi.org/10.1136/ijgc-2022-igcs.109
Autor:
Lenka Rossmeislová, Eva Krauzová, Michal Koc, Marek Wilhelm, Viktor Šebo, Zuzana Varaliová, Veronika Šrámková, Moniek Schouten, Petr Šedivý, Petr Tůma, Jan Kovář, Dominique Langin, Jan Gojda, Michaela Šiklová
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37875- (2024)
Fasting induces significant shifts in substrate utilization with signs of acute insulin resistance (IR), while obesity is associated with chronic IR. Nonetheless, both states substantially influence adipose tissue (AT) function. Therefore, in this in
Externí odkaz:
https://doaj.org/article/9a796c5a2d4649cebfae37b64651269d
Publikováno v:
Journal of cellular and molecular medicine. 26(10)
Duodenal biopsies are considered a suitable source of enterocytes for studies of dietary iron absorption. However, the expression level of molecules involved in iron absorption may vary along the length of duodenum. We aimed to determine whether the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51aa4840d54414ec1acd06d3f770e8b
https://pubmed.ncbi.nlm.nih.gov/35445529
https://pubmed.ncbi.nlm.nih.gov/35445529
Autor:
Karolina Seborova, Alzbeta Kloudova-Spalenkova, Kamila Koucka, Petr Holy, Marie Ehrlichova, Changwei Wang, Iwao Ojima, Iveta Voleska, Petr Daniel, Kamila Balusikova, Michael Jelinek, Jan Kovar, Lukas Rob, Martin Hruda, Marcela Mrhalova, Pavel Soucek, Radka Vaclavikova
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 73, p 73 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 73
International Journal of Molecular Sciences, Vol 23, Iss 73, p 73 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 73
The main problem precluding successful therapy with conventional taxanes is de novo or acquired resistance to taxanes. Therefore, novel experimental taxane derivatives (Stony Brook taxanes; SB-Ts) are synthesized and tested as potential drugs against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e93b98a0a46e06a7db864e9b405956
https://pubmed.ncbi.nlm.nih.gov/35008510
https://pubmed.ncbi.nlm.nih.gov/35008510