Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jan Kotál"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract The hematophagy behavior has evolved independently several times within the Arthropoda phylum. Interestingly, the process of acquiring a blood meal in ticks is considerably distinct from that observed in other blood-feeding arthropods. Inste
Externí odkaz:
https://doaj.org/article/3cac505917114d0c817eb2a3a183b32d
Autor:
Adéla Chlastáková, Barbora Kaščáková, Jan Kotál, Helena Langhansová, Michail Kotsyfakis, Ivana Kutá Smatanová, Lucas Tirloni, Jindřich Chmelař
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Serpins are widely distributed and functionally diverse inhibitors of serine proteases. Ticks secrete serpins with anti-coagulation, anti-inflammatory, and immunomodulatory activities via their saliva into the feeding cavity to modulate host’s hemo
Externí odkaz:
https://doaj.org/article/c69818297654486a922ad1cd9d11a6bb
Autor:
José María Medina, Mohamed Amine Jmel, Brent Cuveele, Cristina Gómez-Martín, Ernesto Aparicio-Puerta, Imen Mekki, Jan Kotál, Larissa Almeida Martins, Michael Hackenberg, Chaima Bensaoud, Michail Kotsyfakis
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Ticks are blood-feeding arthropods that use the components of their salivary glands to counter the host’s hemostatic, inflammatory, and immune responses. The tick midgut also plays a crucial role in hematophagy. It is responsible for managing blood
Externí odkaz:
https://doaj.org/article/17ae4b4aacc142e19e1b26054b57edae
Autor:
Adéla Chlastáková, Jan Kotál, Zuzana Beránková, Barbora Kaščáková, Larissa Almeida Martins, Helena Langhansová, Tatyana Prudnikova, Monika Ederová, Ivana Kutá Smatanová, Michail Kotsyfakis, Jindřich Chmelař
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Tick saliva is a rich source of pharmacologically and immunologically active molecules. These salivary components are indispensable for successful blood feeding on vertebrate hosts and are believed to facilitate the transmission of tick-borne pathoge
Externí odkaz:
https://doaj.org/article/e4a3705082c243d498b7d76c852a5ca8
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The last three decades of research into tick salivary components have revealed several proteins with important pharmacological and immunological activities. Two primary interests have driven research into tick salivary secretions: the search for suit
Externí odkaz:
https://doaj.org/article/e5905680cef841c28e7f9393756c10b3
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host. Three major groups of
Externí odkaz:
https://doaj.org/article/33fd3e1cadbc437ab227bf23a7016528
Autor:
Joel A. Crossley, Tatyana Prudnikova, Larissa Almeida Martins, Helena Langhansová, Zuzana Beránková, Filip Dycka, Michal Kuty, Jindrich Chmelar, Petra Havlickova, Barbora Kascakova, Jan Kotál, Eric Calvo, Michail Kotsyfakis, Ivana Kuta Smatanova
Publikováno v:
Acta Crystallogr D Struct Biol
Iripin-5 is the main Ixodes ricinus salivary serpin, which acts as a modulator of host defence mechanisms by impairing neutrophil migration, suppressing nitric oxide production by macrophages and altering complement functions. Iripin-5 influences hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7dfb9e0fc61f3914336305fb5d8e109
https://doi.org/10.1107/s2059798321007920
https://doi.org/10.1107/s2059798321007920
Autor:
Monika Ederová, James A. Huntington, Helena Langhansová, Zuzana Beránková, Michail Kotsyfakis, Ondřej Hajdušek, Stéphanie G. I. Polderdijk, Jan Kotál, Larissa Almeida Martins, Adéla Chlastáková, Jindřich Chmelař
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 11271, p 11271 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 11271, p 11271 (2021)
The accession code will be added in Section 2 [...]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4469ddc1b9e75b92298f158e71421c
http://europepmc.org/articles/PMC8540359
http://europepmc.org/articles/PMC8540359
Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement
Autor:
Helena Langhansová, Michail Kotsyfakis, Ondřej Hajdušek, Zuzana Beránková, James A. Huntington, Jan Kotál, Monika Ederová, Larissa Almeida Martins, Adéla Chlastáková, Jindřich Chmelař, Stéphanie G. I. Polderdijk
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 9480, p 9480 (2021)
Volume 22
Issue 17
International Journal of Molecular Sciences, Vol 22, Iss 9480, p 9480 (2021)
Volume 22
Issue 17
Tick saliva is a rich source of antihemostatic, anti-inflammatory, and immunomodulatory molecules that actively help the tick to finish its blood meal. Moreover, these molecules facilitate the transmission of tick-borne pathogens. Here we present the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d0d3401b66858e3137355d8267b333
http://europepmc.org/articles/PMC8431025
http://europepmc.org/articles/PMC8431025
Autor:
Edgar Schmitt, Natascha Stergiou, Helena Langhansová, Eric Calvo, Michail Kotsyfakis, Alexandra Schwarz, Jan Kotál, Michael Mareš, Zuzana Beránková, Jan Kopecký, Pavlína Řezáčová, Adéla Chlastáková, Jindřich Chmelař, Michal Buša
Publikováno v:
Cellular and Molecular Life Sciences. 76:2003-2013
To successfully feed, ticks inject pharmacoactive molecules into the vertebrate host including cystatin cysteine protease inhibitors. However, the molecular and cellular events modulated by tick saliva remain largely unknown. Here, we describe and ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86b33541ef7165df6258ab5640f7cb7
https://doi.org/10.1007/s00018-019-03034-3
https://doi.org/10.1007/s00018-019-03034-3