Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jan Kotál"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract The hematophagy behavior has evolved independently several times within the Arthropoda phylum. Interestingly, the process of acquiring a blood meal in ticks is considerably distinct from that observed in other blood-feeding arthropods. Inste
Externí odkaz:
https://doaj.org/article/3cac505917114d0c817eb2a3a183b32d
Autor:
Adéla Chlastáková, Barbora Kaščáková, Jan Kotál, Helena Langhansová, Michail Kotsyfakis, Ivana Kutá Smatanová, Lucas Tirloni, Jindřich Chmelař
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Serpins are widely distributed and functionally diverse inhibitors of serine proteases. Ticks secrete serpins with anti-coagulation, anti-inflammatory, and immunomodulatory activities via their saliva into the feeding cavity to modulate host’s hemo
Externí odkaz:
https://doaj.org/article/c69818297654486a922ad1cd9d11a6bb
Autor:
José María Medina, Mohamed Amine Jmel, Brent Cuveele, Cristina Gómez-Martín, Ernesto Aparicio-Puerta, Imen Mekki, Jan Kotál, Larissa Almeida Martins, Michael Hackenberg, Chaima Bensaoud, Michail Kotsyfakis
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Ticks are blood-feeding arthropods that use the components of their salivary glands to counter the host’s hemostatic, inflammatory, and immune responses. The tick midgut also plays a crucial role in hematophagy. It is responsible for managing blood
Externí odkaz:
https://doaj.org/article/17ae4b4aacc142e19e1b26054b57edae
Autor:
Adéla Chlastáková, Jan Kotál, Zuzana Beránková, Barbora Kaščáková, Larissa Almeida Martins, Helena Langhansová, Tatyana Prudnikova, Monika Ederová, Ivana Kutá Smatanová, Michail Kotsyfakis, Jindřich Chmelař
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Tick saliva is a rich source of pharmacologically and immunologically active molecules. These salivary components are indispensable for successful blood feeding on vertebrate hosts and are believed to facilitate the transmission of tick-borne pathoge
Externí odkaz:
https://doaj.org/article/e4a3705082c243d498b7d76c852a5ca8
Autor:
Jan Kotál, Stéphanie G. I. Polderdijk, Helena Langhansová, Monika Ederová, Larissa A. Martins, Zuzana Beránková, Adéla Chlastáková, Ondřej Hajdušek, Michail Kotsyfakis, James A. Huntington, Jindřich Chmelař
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11271 (2021)
The accession code will be added in Section 2 [...]
Externí odkaz:
https://doaj.org/article/03cc7275f1c9441bb2b4496eba03c70d
Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement
Autor:
Jan Kotál, Stéphanie G. I. Polderdijk, Helena Langhansová, Monika Ederová, Larissa A. Martins, Zuzana Beránková, Adéla Chlastáková, Ondřej Hajdušek, Michail Kotsyfakis, James A. Huntington, Jindřich Chmelař
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9480 (2021)
Tick saliva is a rich source of antihemostatic, anti-inflammatory, and immunomodulatory molecules that actively help the tick to finish its blood meal. Moreover, these molecules facilitate the transmission of tick-borne pathogens. Here we present the
Externí odkaz:
https://doaj.org/article/5487574106bb433f96cec53150e1087f
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The last three decades of research into tick salivary components have revealed several proteins with important pharmacological and immunological activities. Two primary interests have driven research into tick salivary secretions: the search for suit
Externí odkaz:
https://doaj.org/article/e5905680cef841c28e7f9393756c10b3
Autor:
Jan Kotál, Michal Buša, Veronika Urbanová, Pavlína Řezáčová, Jindřich Chmelař, Helena Langhansová, Daniel Sojka, Michael Mareš, Michail Kotsyfakis
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5371 (2021)
The hard tick Ixodes ricinus is a vector of Lyme disease and tick-borne encephalitis. Host blood protein digestion, essential for tick development and reproduction, occurs in tick midgut digestive cells driven by cathepsin proteases. Little is known
Externí odkaz:
https://doaj.org/article/2cd708adb04e4ca185a3d02a5a2694a0
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host. Three major groups of
Externí odkaz:
https://doaj.org/article/33fd3e1cadbc437ab227bf23a7016528
Autor:
Joel A. Crossley, Tatyana Prudnikova, Larissa Almeida Martins, Helena Langhansová, Zuzana Beránková, Filip Dycka, Michal Kuty, Jindrich Chmelar, Petra Havlickova, Barbora Kascakova, Jan Kotál, Eric Calvo, Michail Kotsyfakis, Ivana Kuta Smatanova
Publikováno v:
Acta Crystallogr D Struct Biol
Iripin-5 is the main Ixodes ricinus salivary serpin, which acts as a modulator of host defence mechanisms by impairing neutrophil migration, suppressing nitric oxide production by macrophages and altering complement functions. Iripin-5 influences hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7dfb9e0fc61f3914336305fb5d8e109
https://doi.org/10.1107/s2059798321007920
https://doi.org/10.1107/s2059798321007920