Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Jan Kost"'
Publikováno v:
Oncogenesis, Vol 13, Iss 1, Pp 1-14 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) presents significant challenges due to the inadequacy of existing chemotherapeutics, which often result in toxicity-dependent dose limitations and premature cessation of therapy. Targeted delivery of t
Externí odkaz:
https://doaj.org/article/21affa4ad5fa4ab093c47cbbe4cb4702
Autor:
Maciej Koźlik, Jędrzej Kosiuk, Michał Cogiel, Jan Kost, Daria Hemmerling, Michał Staniszewski, Agnieszka Szczęsna, Wojciech Wojakowski, Tomasz Jadczyk
Publikováno v:
Advances in Simulation, Vol 9, Iss 1, Pp 1-6 (2024)
Abstract Background Invasive electrophysiology (EP) training requires intellectual skills related to the interpretation of intracardiac electrograms. The classic approach to the education of young electrophysiologists focused solely on theoretical kn
Externí odkaz:
https://doaj.org/article/a55b88b8540d4bd8a1d0b2335d6688e2
Publikováno v:
Journal of Imaging, Vol 7, Iss 5, p 87 (2021)
Graphical visualization systems are a common clinical tool for displaying digital images and three-dimensional volumetric data. These systems provide a broad spectrum of information to support physicians in their clinical routine. For example, the fi
Externí odkaz:
https://doaj.org/article/4e9ad837bbdb4a869338a657efebc93e
Autor:
Maciej Kozlik, Jedrzej Kosiuk, Michal Cogiel, Jan Kost, Daria Hemmerling, Michal Staniszewski, Agnieszka Szczesna, Wojciech Wojakowski, Tomasz Jadczyk
Publikováno v:
Heart Rhythm. 20:S407-S408
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dab554f1f21a49dff648398b5b5a174
https://doi.org/10.1016/j.hrthm.2023.03.915
https://doi.org/10.1016/j.hrthm.2023.03.915
Autor:
Jayne E. Murray, Emanuele Valli, Giorgio Milazzo, Chelsea Mayoh, Andrew J. Gifford, Jamie I. Fletcher, Chengyuan Xue, Nisitha Jayatilleke, Firoozeh Salehzadeh, Laura D. Gamble, Jourdin R. C. Rouaen, Daniel R. Carter, Helen Forgham, Eric O. Sekyere, Joanna Keating, Georgina Eden, Sophie Allan, Stephanie Alfred, Frances K. Kusuma, Ashleigh Clark, Hannah Webber, Amanda J. Russell, Antoine de Weck, Benjamin T. Kile, Martina Santulli, Piergiuseppe De Rosa, Emmy D. G. Fleuren, Weiman Gao, Lorna Wilkinson-White, Jason K. K. Low, Joel P. Mackay, Glenn M. Marshall, Douglas J. Hilton, Federico M. Giorgi, Jan Koster, Giovanni Perini, Michelle Haber, Murray D. Norris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract MYCN oncogene amplification is frequently observed in aggressive childhood neuroblastoma. Using an unbiased large-scale mutagenesis screen in neuroblastoma-prone transgenic mice, we identify a single germline point mutation in the transcript
Externí odkaz:
https://doaj.org/article/ee532e0c05a8415d9de099a04d9f475c
Autor:
Noah Bonine, Vittorio Zanzani, Annelies Van Hemelryk, Bavo Vanneste, Christian Zwicker, Tinne Thoné, Sofie Roelandt, Sarah-Lee Bekaert, Jan Koster, Isabelle Janoueix-Lerosey, Cécile Thirant, Stéphane Van Haver, Stephen S. Roberts, Liselot M. Mus, Bram De Wilde, Nadine Van Roy, Celine Everaert, Frank Speleman, Vanessa Vermeirssen, Charlotte L. Scott, Katleen De Preter
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114804- (2024)
Summary: Neuroblastoma, a rare embryonic tumor arising from neural crest development, is responsible for 15% of pediatric cancer-related deaths. Recently, several single-cell transcriptome studies were performed on neuroblastoma patient samples to in
Externí odkaz:
https://doaj.org/article/881e70f45b494476aa7c75fe6611cb10
Autor:
Dennis S. Metselaar, Michaël H. Meel, Joshua R. Goulding, Aimeé du Chatinier, Leyla Rigamonti, Piotr Waranecki, Neal Geisemeyer, Mark C. de Gooijer, Marjolein Breur, Jan Koster, Sophie E.M. Veldhuijzen van Zanten, Marianna Bugiani, Niels E. Franke, Alyssa Reddy, Pieter Wesseling, Gertjan J.L. Kaspers, Esther Hulleman
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101700- (2024)
Summary: Atypical teratoid/rhabdoid tumors (ATRTs) are highly malignant embryonal tumors of the central nervous system with a dismal prognosis. Using a newly developed and validated patient-derived ATRT culture and xenograft model, alongside a panel
Externí odkaz:
https://doaj.org/article/dad8aa161f6e4aad834b1c8a6839ea6b
Autor:
Dajia Liu, Amber P. van der Zalm, Jan Koster, Sanne Bootsma, Cesar Oyarce, Hanneke W.M. van Laarhoven, Maarten F. Bijlsma
Publikováno v:
Pharmacological Research, Vol 207, Iss , Pp 107315- (2024)
Epithelial-mesenchymal transition (EMT) has been identified as a driver of therapy resistance, particularly in esophageal adenocarcinoma (EAC), where transforming growth factor beta (TGF-β) can induce this process. Inhibitors of TGF-β may counterac
Externí odkaz:
https://doaj.org/article/693617776d904183909d7cef03180eb3
Autor:
Saskia Sydow, Paul Piccinelli, Shamik Mitra, Panagiotis Tsagkozis, Asle Hesla, Camila B. R. De Mattos, Jan Köster, Linda Magnusson, Jenny Nilsson, Adam Ameur, René Wardenaar, Floris Foijer, Diana Spierings, Fredrik Mertens
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Well-differentiated liposarcoma (WDLS) displays amplification of genes on chromosome 12 (Chr12) in supernumerary ring or giant marker chromosomes. These structures have been suggested to develop through chromothripsis, followed by circulariz
Externí odkaz:
https://doaj.org/article/da20dec8d740493cb0e315d44871f437
Autor:
Amber P. van der Zalm, Mark P. G. Dings, Paul Manoukian, Hannah Boersma, Reimer Janssen, Peter Bailey, Jan Koster, Danny Zwijnenburg, Richard Volckmann, Sanne Bootsma, Cynthia Waasdorp, Monique van Mourik, Dionne Blangé, Tom van den Ende, César I. Oyarce, Sarah Derks, Aafke Creemers, Eva A. Ebbing, Gerrit K. Hooijer, Sybren L. Meijer, Mark I. van Berge Henegouwen, Jan Paul Medema, Hanneke W. M. van Laarhoven, Maarten F. Bijlsma
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-11 (2024)
Abstract Background Despite the advent of neoadjuvant chemoradiotherapy (CRT), overall survival rates of esophageal adenocarcinoma (EAC) remain low. A readily induced mesenchymal transition of EAC cells contributes to resistance to CRT. Methods In th
Externí odkaz:
https://doaj.org/article/d7fc9df802d34addb7ab614129c458e9