Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Jan Koch-Weser"'
Autor:
Jan Koch-Weser, Edward M. Sellers
Publikováno v:
New England Journal of Medicine. 294:526-531
Most drugs are carried from their sites of absorption to their sites of action and elimination by the circulating blood. Some drugs are simply dissolved in serum water, but many others are partly a...
Publikováno v:
Clinical Pharmacology & Therapeutics. 16:284-287
Autor:
Jan Koch-Weser
Publikováno v:
New England Journal of Medicine. 291:233-237
SYSTEMIC drugs administered orally or parenterally must reach the general circulation in their pharmacologically active form to be distributed throughout the body and to exert therapeutic effects a...
Autor:
Paul J. Schechter, Jan Koch-Weser, G. Tell, J.-M. Warter, L. Rumbach, Jeffrey Grove, C. Marescaux
Publikováno v:
Journal of Neurochemistry. 39:1061-1065
Samples of untreated human cerebrospinal fluid (CSF) were kept at room temperature (20 +/- 1 degree C) up to 72 h, and changes in gamma-aminobutyric acid (GABA) and homocarnosine contents were measured. The concentration of free GABA increased with t
Autor:
Jan Koch-Weser, David J. Greenblatt
Publikováno v:
The American Journal of the Medical Sciences. 266:261-266
Publikováno v:
The Journal of Clinical Pharmacology. 17:108-119
Five hundred fifty-seven 24-hour urinary creatinine specimens from eight healthy males collected in six-day sequences separated by two- to ten-week intervals over six to ten months were analyzed for factors contributing to the large observed standard
Publikováno v:
New England Journal of Medicine. 305:1560-1564
Autor:
Jan Koch-Weser, Richard I. Shader, David J. Greenblatt, Kate Franke, Dean S. MacLaughlin, Bernard J. Ransil
Publikováno v:
Clinical Pharmacology & Therapeutics. 22:893-903
Publikováno v:
Pharmacology. 13:248-251
Biotransformation of chlordiazepoxide was studied in mice following a single 1000-rad dose of hepatic irradiation. Meabolic N-demethylation of chlordiazepoxide in irradiated mice was impaired when tested 3 days after irradiation. No such effect was o
Autor:
David J. Greenblatt, Jan Koch-Weser
Publikováno v:
American Heart Journal. 86:478-484
Of 13,349 hospitalized medical patients monitored in a drug surveillance program, 268 (2.0 per cent) received propranolol during one or more hospitalizations. Angina and cardiac arrhythmias were the most common indications for therapy. Adverse reacti