Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jan Klocke"'
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury
Autor:
Christian Hinze, Christine Kocks, Janna Leiz, Nikos Karaiskos, Anastasiya Boltengagen, Shuang Cao, Christopher Mark Skopnik, Jan Klocke, Jan-Hendrik Hardenberg, Helena Stockmann, Inka Gotthardt, Benedikt Obermayer, Laleh Haghverdi, Emanuel Wyler, Markus Landthaler, Sebastian Bachmann, Andreas C. Hocke, Victor Corman, Jonas Busch, Wolfgang Schneider, Nina Himmerkus, Markus Bleich, Kai-Uwe Eckardt, Philipp Enghard, Nikolaus Rajewsky, Kai M. Schmidt-Ott
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-18 (2022)
Abstract Background Acute kidney injury (AKI) occurs frequently in critically ill patients and is associated with adverse outcomes. Cellular mechanisms underlying AKI and kidney cell responses to injury remain incompletely understood. Methods We perf
Externí odkaz:
https://doaj.org/article/2152453158884a80961272912072ce81
Autor:
Emil Grothgar, Nina Goerlich, Bjoern Samans, Christopher M. Skopnik, Diana Metzke, Jan Klocke, Luka Prskalo, Paul Freund, Leonie Wagner, Michael Duerr, Mareen Matz, Sven Olek, Klemens Budde, Alexander Paliege, Philipp Enghard
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Early detection of kidney transplant (KT) rejection remains a challenge in patient care. Non-invasive biomarkers hold high potential to detect rejection, adjust immunosuppression, and monitor KT patients. So far, no approach has fully satisfied requi
Externí odkaz:
https://doaj.org/article/f861514a65694e139d6d4fdcfe5a4963
Autor:
Zhi Bo Zhao, Julian A. Marschner, Takamasa Iwakura, Chenyu Li, Manga Motrapu, Meisi Kuang, Bastian Popper, Andreas Linkermann, Jan Klocke, Philipp Enghard, Yoshiharu Muto, Benjamin D. Humphreys, Helena Erlandsson Harris, Paola Romagnani, Hans-Joachim Anders
Publikováno v:
Journal of the American Society of Nephrology. 34:394-411
Autor:
Jan Klocke, Seung Joon Kim, Christopher M. Skopnik, Christian Hinze, Anastasiya Boltengagen, Diana Metzke, Emil Grothgar, Luka Prskalo, Leonie Wagner, Paul Freund, Nina Görlich, Frédéric Muench, Kai M. Schmidt-Ott, Mir-Farzin Mashreghi, Christine Kocks, Kai-Uwe Eckardt, Nikolaus Rajewsky, Philipp Enghard
Publikováno v:
Kidney International. 102:1359-1370
Acute kidney injury (AKI) is a major health issue, the outcome of which depends primarily on damage and reparative processes of tubular epithelial cells. Mechanisms underlying AKI remain incompletely understood, specific therapies are lacking and mon
Autor:
Paul Freund, Christopher M. Skopnik, Diana Metzke, Nina Goerlich, Jan Klocke, Emil Grothgar, Luka Prskalo, Falk Hiepe, Philipp Enghard
Publikováno v:
Cytometry Part B: Clinical Cytometry.
Autor:
Janis Sonnemann, Jan Klocke, Markus Bieringer, Anthony Rousselle, Kai-Uwe Eckardt, Saban Elitok, Suncica Popovic, Sebastian Bachmann, Ralph Kettritz, Alan D. Salama, Philipp Enghard, Adrian Schreiber
Publikováno v:
Kidney Int Rep
INTRODUCTION: Necrotizing crescentic glomerulonephritis is a major contributor to morbidity and mortality in Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). Because therapy relies on immunosuppressive agents with potentially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3caa6f43ff9904a12beda3a636d9f141
https://europepmc.org/articles/PMC10105048/
https://europepmc.org/articles/PMC10105048/
Autor:
Paul Freund, Christopher M. Skopnik, Diana Metzke, Nina Goerlich, Jan Klocke, Emil Grothgar, Luka Prskalo, Falk Hiepe, Philipp Enghard
Kidney diseases are a major health concern worldwide. Currently there is a large unmet need for novel biomarkers to non-invasively diagnose and monitor kidney diseases. Urinary cells are promising biomarkers and their analysis by flow cytometry has d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::581c4be77b91968cd8ee19466082d4e3
https://doi.org/10.1101/2022.04.07.22273579
https://doi.org/10.1101/2022.04.07.22273579
Autor:
Jan Klocke, Seung Joon Kim, Christopher M. Skopnik, Christian Hinze, Anastasiya Boltengagen, Diana Metzke, Emil Grothgar, Luka Prskalo, Leonie Wagner, Paul Freund, Nina Görlich, Frédéric Muench, Kai M. Schmidt-Ott, Mir-Farzin Mashreghi, Christine Kocks, Kai-Uwe Eckardt, Nikolaus Rajewsky, Philipp Enghard
Acute kidney injury (AKI) is a major health issue, the outcome of which depends primarily on damage and reparative processes of tubular epithelial cells (TEC). Mechanisms underlying AKI remain incompletely understood, specific therapies are lacking a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e5640143f2ed80de8a7a78cc12ff24d
https://doi.org/10.1101/2022.02.15.479234
https://doi.org/10.1101/2022.02.15.479234
Autor:
Jacob Kujat, Valerie Langhans, Hannah Brand, Paul Freund, Nina Görlich, Leonie Wagner, Diana Metzke, Sara Timm, Matthias Ochs, Andreas Grützkau, Sabine Baumgart, Christopher M. Skopnik, Falk Hiepe, Gabriela Riemekasten, Jan Klocke, Philipp Enghard
IntroductionAcute kidney injury (AKI) is associated with significant morbidity and mortality. The diagnosis is currently based on urine output and serum creatinine and there is a lack of biomarkers that directly reflect tubular damage. Here, we estab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::728035f115bf5308b80652b888965355
https://doi.org/10.1101/2022.01.31.22270101
https://doi.org/10.1101/2022.01.31.22270101
Autor:
Christian Hinze, Christine Kocks, Janna Leiz, Nikos Karaiskos, Anastasiya Boltengagen, Christopher Mark Skopnik, Jan Klocke, Jan-Hendrik Hardenberg, Helena Stockmann, Inka Gotthardt, Benedikt Obermayer, Laleh Haghverdi, Emanuel Wyler, Markus Landthaler, Sebastian Bachmann, Andreas C. Hocke, Victor Corman, Jonas Busch, Wolfgang Schneider, Nina Himmerkus, Markus Bleich, Kai-Uwe Eckardt, Philipp Enghard, Nikolaus Rajewsky, Kai M. Schmidt-Ott
BackgroundAcute kidney injury (AKI) occurs frequently in critically ill patients and is associated with adverse outcomes. Cellular mechanisms underlying AKI and kidney cell responses to injury remain incompletely understood.MethodsWe performed single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e0d09ba32033fac8697b54ed217d1e1
https://doi.org/10.1101/2021.12.15.472619
https://doi.org/10.1101/2021.12.15.472619