Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Jan Kitajewski"'
Autor:
Qanber Raza, Taliha Nadeem, Seock-Won Youn, Bhairavi Swaminathan, Ahana Gupta, Timothy Sargis, Jing Du, Henar Cuervo, Anne Eichmann, Susan L. Ackerman, L. A. Naiche, Jan Kitajewski
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Notch signaling guides vascular development and function by regulating diverse endothelial cell behaviors, including migration, proliferation, vascular density, endothelial junctions, and polarization in response to flow. Notch proteins form
Externí odkaz:
https://doaj.org/article/8047816dc98f4fb0bf8cf2e7ace6b0bc
Autor:
Michael G. Poulos, Pradeep Ramalingam, Michael C. Gutkin, Maria Kleppe, Michael Ginsberg, Michael J. P. Crowley, Olivier Elemento, Ross L. Levine, Shahin Rafii, Jan Kitajewski, Matthew B. Greenblatt, Jae-Hyuck Shim, Jason M. Butler
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
The complex microenvironmental signalling pathways that govern haematopoietic stem cell (HSC) activity remain poorly defined. Here, the authors identify endothelial NF-κB signalling as regulating regenerative HSC function, accelerating haematopoieti
Externí odkaz:
https://doaj.org/article/95743d5eec914dfda2ea75f85a602491
Autor:
Zina Dubeykovskaya, Yiling Si, Xiaowei Chen, Daniel L. Worthley, Bernhard W. Renz, Aleksandra M. Urbanska, Yoku Hayakawa, Ting Xu, C. Benedikt Westphalen, Alexander Dubeykovskiy, Duan Chen, Richard A. Friedman, Samuel Asfaha, Karan Nagar, Yagnesh Tailor, Sureshkumar Muthupalani, James G. Fox, Jan Kitajewski, Timothy C. Wang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
During colorectal inflammation and cancer, myeloid cells accumulate in the spleen and suppress the host immunity response. In this study, the authors use a mouse model of colitis to demonstrate that upon vagus stimulation splenic memory T cells relea
Externí odkaz:
https://doaj.org/article/67d8a761a2b64f5c8b8c4095b1685dfc
Autor:
Max Werth, Kai M Schmidt-Ott, Thomas Leete, Andong Qiu, Christian Hinze, Melanie Viltard, Neal Paragas, Carrie J Shawber, Wenqiang Yu, Peter Lee, Xia Chen, Abby Sarkar, Weiyi Mu, Alexander Rittenberg, Chyuan-Sheng Lin, Jan Kitajewski, Qais Al-Awqati, Jonathan Barasch
Publikováno v:
eLife, Vol 6 (2017)
Although most nephron segments contain one type of epithelial cell, the collecting ducts consists of at least two: intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively. In adult kidneys, these
Externí odkaz:
https://doaj.org/article/24d5342b565a4432ae63499df84881e5
Autor:
Michael G. Poulos, Peipei Guo, Natalie M. Kofler, Sandra Pinho, Michael C. Gutkin, Anastasia Tikhonova, Iannis Aifantis, Paul S. Frenette, Jan Kitajewski, Shahin Rafii, Jason M. Butler
Publikováno v:
Cell Reports, Vol 4, Iss 5, Pp 1022-1034 (2013)
The bone marrow (BM) microenvironment is composed of multiple niche cells that, by producing paracrine factors, maintain and regenerate the hematopoietic stem cell (HSC) pool (Morrison and Spradling, 2008). We have previously demonstrated that endoth
Externí odkaz:
https://doaj.org/article/a2de7d96b8d94890af4dc12d7b19d166
Publikováno v:
Toxins, Vol 5, Iss 2, Pp 315-326 (2013)
The genes encoding Anthrax Toxin Receptors (ANTXRs) were originally identified based on expression in endothelial cells suggesting a role in angiogenesis. The focus of this review is to discuss what has been learned about the physiological roles of t
Externí odkaz:
https://doaj.org/article/83c549ebdb2e4779a53c64c3422ba4e4
Autor:
Katharina S Volz, Andrew H Jacobs, Heidi I Chen, Aruna Poduri, Andrew S McKay, Daniel P Riordan, Natalie Kofler, Jan Kitajewski, Irving Weissman, Kristy Red-Horse
Publikováno v:
eLife, Vol 4 (2015)
Epicardial cells on the heart’s surface give rise to coronary artery smooth muscle cells (caSMCs) located deep in the myocardium. However, the differentiation steps between epicardial cells and caSMCs are unknown as are the final maturation signals
Externí odkaz:
https://doaj.org/article/122633ec49124bdf855c84990fcae4be
Publikováno v:
BioTechniques, Vol 28, Iss 4, Pp 702-708 (2000)
We have developed a retroviral vector that incorporates unique features of some previously described vectors. This vector includes: 3′ long terminal repeats (LTRs) of the self-inactivating class; a 5′ LTR that is a hybrid of the cytomegalovirus (
Externí odkaz:
https://doaj.org/article/35822f2bd71b4bf582cd216565ca7b39
Publikováno v:
Cancer Research. 83:P6-14
While early detection of breast cancer (BC) has improved prognoses, there is an urgent need to improve outcomes for patients with distant metastatic disease. Higher expression of the Notch ligand JAG1 in primary BC tumors is strongly associated with
Autor:
Kiyoshi Saeki, Wanglong Qiu, Richard A. Friedman, Samuel Pan, Jordan Lu, Shu Ichimiya, Iok In Christine Chio, Carrie J. Shawber, Jan Kitajewski, Jianhua Hu, Gloria H. Su
Publikováno v:
Cancer Research Communications. 2:1601-1616
Expression of the Notch family of receptors is often upregulated in pancreatic ductal adenocarcinoma (PDAC). In this study, we focused on Notch4, which had not been investigated in PDAC. We generated KC (LSL-KrasG12D;p48-Cre), N4−/−KC (Notch4−/