Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Jan Kisielow"'
Autor:
Meng Xu, Taku Ito-Kureha, Hyun-Seo Kang, Aleksandar Chernev, Timsse Raj, Kai P. Hoefig, Christine Hohn, Florian Giesert, Yinhu Wang, Wenliang Pan, Natalia Ziętara, Tobias Straub, Regina Feederle, Carolin Daniel, Barbara Adler, Julian König, Stefan Feske, George C. Tsokos, Wolfgang Wurst, Henning Urlaub, Michael Sattler, Jan Kisielow, F. Gregory Wulczyn, Marcin Łyszkiewicz, Vigo Heissmeyer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/9e89d380ba524171be8ac6b2c5c274ad
Autor:
Meng Xu, Taku Ito-Kureha, Hyun-Seo Kang, Aleksandar Chernev, Timsse Raj, Kai P. Hoefig, Christine Hohn, Florian Giesert, Yinhu Wang, Wenliang Pan, Natalia Ziętara, Tobias Straub, Regina Feederle, Carolin Daniel, Barbara Adler, Julian König, Stefan Feske, George C. Tsokos, Wolfgang Wurst, Henning Urlaub, Michael Sattler, Jan Kisielow, F. Gregory Wulczyn, Marcin Łyszkiewicz, Vigo Heissmeyer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The regulation of thymocyte development by RNA-binding proteins (RBPs) is largely unexplored. We identify 642 RBPs in the thymus and focus on Arpp21, which shows selective and dynamic expression in early thymocytes. Arpp21 is downregulated i
Externí odkaz:
https://doaj.org/article/c1ccb1c3902a42deb7a8b59d19e9f6cb
Autor:
Federica Piattini, Christelle Le Foll, Jan Kisielow, Esther Rosenwald, Peter Nielsen, Thomas Lutz, Christoph Schneider, Manfred Kopf
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 131-141 (2019)
Objective: Leptin (Lep) plays a crucial role in controlling food intake and energy expenditure. Defective Lep/LepRb-signaling leads to fat accumulation, massive obesity, and the development of diabetes. We serendipitously noticed spontaneous developm
Externí odkaz:
https://doaj.org/article/565a3e66297d470a8980c9b3802a0777
Autor:
Jonathan Muri, Sebastian Heer, Mai Matsushita, Lea Pohlmeier, Luigi Tortola, Tobias Fuhrer, Marcus Conrad, Nicola Zamboni, Jan Kisielow, Manfred Kopf
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Thioredoxin (Trx), Trx reductase, Txnip and NADPH together comprise the Trx system. Here the authors make a T cell-specific thioredoxin reductase-1 knockout mouse to show how this system reprograms cellular metabolism to enable T cell development, pr
Externí odkaz:
https://doaj.org/article/fcad0513f85e4a638f4a7ad39f2c3972
Autor:
Likai Tan, Inga Sandrock, Ivan Odak, Yuval Aizenbud, Anneke Wilharm, Joana Barros-Martins, Yaara Tabib, Alina Borchers, Tiago Amado, Lahiru Gangoda, Marco J. Herold, Marc Schmidt-Supprian, Jan Kisielow, Bruno Silva-Santos, Christian Koenecke, Avi-Hai Hovav, Christian Krebs, Immo Prinz, Sarina Ravens
Publikováno v:
Cell Reports, Vol 27, Iss 12, Pp 3657-3671.e4 (2019)
Summary: IL-17-producing γδ T cells express oligoclonal Vγ4+ and Vγ6+ TCRs, mainly develop in the prenatal thymus, and later persist as long-lived self-renewing cells in all kinds of tissues. However, their exchange between tissues and the mechan
Externí odkaz:
https://doaj.org/article/ec7de8c74d424a13bcfd9f15aebb183d
Autor:
Franz-Josef Obermair, Florian Renoux, Sebastian Heer, Chloe H. Lee, Nastassja Cereghetti, Marisa Loi, Giulia Maestri, Yannick Haldner, Robin Wuigk, Ohad Iosefson, Pooja Patel, Katherine Triebel, Manfred Kopf, Joanna Swain, Jan Kisielow
Publikováno v:
Science Advances, 8 (17)
Understanding peptide presentation by specific MHC alleles is fundamental for controlling physiological functions of T cells and harnessing them for therapeutic use. However, commonly used in silico predictions and mass spectroscopy have their limita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6aea495b0f3d8f1cf061c7e3fd15053
https://doi.org/10.1126/sciadv.abl5394
https://doi.org/10.1126/sciadv.abl5394
Publikováno v:
European Journal of Immunology, 52 (6)
T-cell responses against tumors and pathogens are critically shaped by cosignaling molecules providing a second signal. Interaction of herpes virus entry mediator (HVEM, CD270, TNFRSF14) with multiple ligands has been proposed to promote or inhibit T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361e949aee18d3670ec3a7eba8ae2a09
https://pubmed.ncbi.nlm.nih.gov/35344223
https://pubmed.ncbi.nlm.nih.gov/35344223
Autor:
Ari Waisman, Pawel Durek, Nicole Puertas, Mir-Farzin Mashreghi, Marianne R. Spalinger, Stefan Floess, Mirjam Lutz, Ekaterina Friebel, Benedict Becher, Florian Ingelfinger, Florian Mair, Ana Amorim, Claudia Haftmann, Stefanie Schärli, Pascale Zwicky, Burkhard Becher, Jochen Huehn, René Riedel, Jan Kisielow, Brian P. Leung
Publikováno v:
Science Immunology. 6
Medullary thymic epithelial cells (mTECs) are key antigen-presenting cells mediating T cell tolerance to prevent harmful autoimmunity. mTECs both negatively select self-reactive T cells and promote...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f35fecd808f2c421a19daed277a4e0a9
https://doi.org/10.1126/sciimmunol.abf3111
https://doi.org/10.1126/sciimmunol.abf3111
Autor:
Claudia, Haftmann, Pascale, Zwicky, Florian, Ingelfinger, Florian, Mair, Stefan, Floess, René, Riedel, Pawel, Durek, Marianne R, Spalinger, Ekaterina, Friebel, Brian P, Leung, Mirjam, Lutz, Nicole, Puertas, Ana, Amorim, Stefanie, Schärli, Benedict, Becher, Jan, Kisielow, Ari, Waisman, Mir-Farzin, Mashreghi, Jochen, Huehn, Burkhard, Becher
Publikováno v:
Science immunology. 6(65)
Medullary thymic epithelial cells (mTECs) are key antigen-presenting cells mediating T cell tolerance to prevent harmful autoimmunity. mTECs both negatively select self-reactive T cells and promote the development of thymic regulatory T cells (tT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9fc389608a39e9bee0edacc509da408
https://pubmed.ncbi.nlm.nih.gov/34797691
https://pubmed.ncbi.nlm.nih.gov/34797691